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            Dotinurad, a novel urate transporter (URAT1) inhibitor for gout with potential to address other conditions associated with hyperuricemia such as chronic kidney disease.

            Lead Product(s): Dotinurad

            Therapeutic Area: Rheumatology Product Name: Urece

            Highest Development Status: Phase I Product Type: Small molecule

            Partner/Sponsor/Collaborator: Fortress Biotech

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 29, 2023

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            PRX-115 is a PEGylated enzyme expressed via ProCellEx® for intravenous (IV) administration of recombinant Uricase, designed for safe and efficacious treatment of refractory gout

            Lead Product(s): PRX-115

            Therapeutic Area: Rheumatology Product Name: PRX-115

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 21, 2023

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            HZN-457 is a small interfering RNA (siRNA) medicine candidate conjugated to N-acetylgalactosamine (GalNAc) that selectively targets and silences xanthine dehydrogenase expression in the liver, which produces uric acid.

            Lead Product(s): HZN-457

            Therapeutic Area: Rheumatology Product Name: HZN-457

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Arrowhead Pharmaceuticals

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 08, 2022

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            Natrunix is a new drug, discovered and manufactured at XBiotech’s research and development headquarters in Austin, Texas. The Company believes Natrunix holds promise as a breakthrough therapy for the treatment of inflammatory joint diseases.

            Lead Product(s): XB2001

            Therapeutic Area: Rheumatology Product Name: Natrunix

            Highest Development Status: Phase I Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable December 13, 2021

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