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Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"CANADA","productType":"Controlled Substance","year":"2023","type":"Inapplicable","leadProduct":"Dimethyltryptamine","moa":"5-HT2A receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Algernon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Algernon Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Algernon Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Algernon Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"CANADA","productType":"Controlled Substance","year":"2023","type":"Inapplicable","leadProduct":"Dimethyltryptamine","moa":"5-HT2A receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Algernon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Algernon Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Algernon Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Algernon Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"CANADA","productType":"Controlled Substance","year":"2022","type":"Inapplicable","leadProduct":"Dimethyltryptamine","moa":"5-HT2A receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Algernon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Algernon Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Algernon Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Algernon Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"CANADA","productType":"Controlled Substance","year":"2021","type":"Inapplicable","leadProduct":"Dimethyltryptamine","moa":"5-HT2A receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Algernon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Algernon Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Algernon Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Algernon Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"CANADA","productType":"Controlled Substance","year":"2022","type":"Inapplicable","leadProduct":"Dimethyltryptamine","moa":"5-HT2A receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Algernon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Algernon Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Algernon Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Algernon Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"CANADA","productType":"Controlled Substance","year":"2022","type":"Inapplicable","leadProduct":"Dimethyltryptamine","moa":"5-HT2A receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Algernon Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"Algernon Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Algernon Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"XBiotech","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Antibody","year":"2023","type":"Inapplicable","leadProduct":"Hutrukin","moa":"Undisclosed","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"XBiotech","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"XBiotech \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"XBiotech \/ Inapplicable"},{"orgOrder":0,"company":"XBiotech","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Antibody","year":"2023","type":"Inapplicable","leadProduct":"Hutrukin","moa":"Undisclosed","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"XBiotech","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Injection","sponsorNew":"XBiotech \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"XBiotech \/ Inapplicable"},{"orgOrder":0,"company":"Sirnaomics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Oligonucleotide","year":"2023","type":"Inapplicable","leadProduct":"STP122G","moa":"Factor XI","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Sirnaomics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Sirnaomics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Sirnaomics \/ Inapplicable"},{"orgOrder":0,"company":"CytoDyn","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Antibody","year":"2020","type":"Inapplicable","leadProduct":"Leronlimab","moa":"CXCR-5 receptor","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"CytoDyn","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"CytoDyn \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"CytoDyn \/ Inapplicable"},{"orgOrder":0,"company":"Cellino","sponsor":"Karis Bio","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Partnership","leadProduct":"iPSC-EC","moa":"Undisclosed","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Cellino","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Cellino \/ Karis Bio","highestDevelopmentStatusID":"6","companyTruncated":"Cellino \/ Karis Bio"},{"orgOrder":0,"company":"YolTech Therapeutics","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"CHINA","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"YOLT-101","moa":"PCSK9","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"YolTech Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Intravenous Infusion","sponsorNew":"YolTech Therapeutics \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"YolTech Therapeutics \/ Inapplicable"},{"orgOrder":0,"company":"Aspire Biopharma","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Cardiology\/Vascular Diseases","country":"PUERTO RICO","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Aspirin","moa":"Cyclooxygenase","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Aspire Biopharma","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":0,"dosageForm":"Sublingual Powder","sponsorNew":"Aspire Biopharma \/ Inapplicable","highestDevelopmentStatusID":"6","companyTruncated":"Aspire Biopharma \/ Inapplicable"},{"orgOrder":0,"company":"Verve Therapeutics","sponsor":"Eli Lilly","pharmaFlowCategory":"D","therapeuticArea":"Cardiology\/Vascular Diseases","country":"U.S.A","productType":"Cell and Gene therapy","year":"2025","type":"Acquisition","leadProduct":"VERVE-102","moa":"PCSK9","graph1":"Cardiology\/Vascular Diseases","graph2":"Phase I","graph3":"Verve Therapeutics","amount2":1.3,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Cardiovascular Diseases","amount2New":1.3,"dosageForm":"Intravenous Infusion","sponsorNew":"Verve Therapeutics \/ Eli Lilly","highestDevelopmentStatusID":"6","companyTruncated":"Verve Therapeutics \/ Eli Lilly"}]

    Find Drugs for Cardiology/Vascular Diseases in Phase I Clinical Development

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                            01

                            Verve Therapeutics

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                            Verve Therapeutics

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                            Lead Product(s) : VERVE-102

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Eli Lilly

                            Deal Size : $1,300.0 million

                            Deal Type : Acquisition

                            DEALS_DEV arrow-down

                            Eli Lilly nears $1.3 billion deal for gene-editing biotech Verve Therapeutics

                            Details : Through the acquisition, Lilly will levrage Verve's pipeline of gene editing medicines, which includes VERVE-102, being evaluated for the treatment of Heterozygous Familial Hypercholesterolemia.

                            Product Name : VERVE-102

                            Product Type : Cell and Gene therapy

                            Upfront Cash : $1,000.0 million

                            June 16, 2025

                            Lead Product(s) : VERVE-102

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Eli Lilly

                            Deal Size : $1,300.0 million

                            Deal Type : Acquisition

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                            02

                            Aspire Biopharma

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                            EPS
                            Not Confirmed

                            Aspire Biopharma

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                            EPS
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                            Lead Product(s) : Aspirin

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Aspire Biopharma Doses First Patient in Phase 1 Trial for Fast-Acting Oral Aspirin

                            Details : The first patient has been dosed in Aspire's Phase I to evaluate its lead therapeutic candidate, an oral transmucosal fast-acting high-dose aspirin formulation.

                            Product Name : Undisclosed

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 20, 2025

                            Lead Product(s) : Aspirin

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            YolTech Therapeutics

                            China arrow
                            EPS
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                            YolTech Therapeutics

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                            Lead Product(s) : YOLT-101

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            YolTech Shares Initial Data On YOLT-101 In-Vivo Base Editing for Cholesterol

                            Details : YOLT-101 is a next-generation in vivo base-editing therapeutic, being evaluating in the early-stage clinical trial studies for the treatment of Familial Hypercholesterolemia.

                            Product Name : YOLT-101

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            April 28, 2025

                            Lead Product(s) : YOLT-101

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Cellino

                            U.S.A arrow
                            EPS
                            Not Confirmed

                            Cellino

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                            EPS
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                            Lead Product(s) : iPSC-EC

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Karis Bio

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            Cellino and Karis Bio Develop Nebula-Powered iPSC Therapy for Heart Disease

                            Details : The partnership aims to industrialize the world’s first clinical-stage autologous iPSC-derived cell therapy for peripheral artery disease (PAD) and coronary artery disease (CAD).

                            Product Name : iPSC-EC

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Undisclosed

                            April 15, 2025

                            Lead Product(s) : iPSC-EC

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Karis Bio

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            05

                            Secretome Therapeutics

                            U.S.A arrow
                            EPS
                            Not Confirmed

                            Secretome Therapeutics

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                            EPS
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                            Lead Product(s) : STM-01

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Secretome Doses First Patient in Phase 1 STM-01 Heart Failure Study

                            Details : STM-01 is an investigational, allogeneic neonatal cardiac progenitor cell (nCPC) therapy to improve cardiac function in patients with HFpEF and other inflammatory-driven cardiovascular diseases.

                            Product Name : STM-01

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            March 25, 2025

                            Lead Product(s) : STM-01

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            Beijing Sungen Biomedical Technology

                            China arrow
                            EPS
                            Not Confirmed

                            Beijing Sungen Biomedical Technology

                            China arrow
                            EPS
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                            Lead Product(s) : SGC001

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sungen’s SGC001 mAb Gets FDA Fast Track Approval as World-First Drug

                            Details : SGC001 is a monoclonal antibody, which is currently being evaluated for the treatment of patients suffering from acute myocardial infarction.

                            Product Name : SGC001

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            March 24, 2025

                            Lead Product(s) : SGC001

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Secretome Therapeutics

                            U.S.A arrow
                            EPS
                            Not Confirmed

                            Secretome Therapeutics

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                            EPS
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                            Lead Product(s) : STM-01

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Secretome’s STM-01 gets FDA Fast Track for HFpEF Neonatal Cell Therapy

                            Details : STM-01 is an investigational, allogeneic neonatal cardiac progenitor cell (nCPC) therapy to improve cardiac function in patients with HFpEF and other inflammatory-driven cardiovascular diseases.

                            Product Name : STM-01

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            March 20, 2025

                            Lead Product(s) : STM-01

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Rona Therapeutics

                            China arrow
                            EPS
                            Not Confirmed

                            Rona Therapeutics

                            China arrow
                            EPS
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                            Lead Product(s) : RN0361

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Rona Therapeutics Gets FDA IND Nod for Phase 2 Trial of RN0361 in Hypertriglyceridemia

                            Details : RN0361 is a potential best-in-class APOC3 target siRNA, which is currently being evaluated for the treatment of severe hypertriglyceridemia.

                            Product Name : RN0361

                            Product Type : Oligonucleotide

                            Upfront Cash : Inapplicable

                            March 17, 2025

                            Lead Product(s) : RN0361

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Kiniksa Pharmaceuticals

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                            EPS
                            Not Confirmed

                            Kiniksa Pharmaceuticals

                            U.S.A arrow
                            EPS
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                            Lead Product(s) : KPL-387

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Kiniksa Develops KPL-387 for Recurrent Pericarditis, Updates Strategy

                            Details : KPL-387 is a monoclonal antibody that binds and inhibits human interleukin-1 receptor 1, currently being investigated for recurrent pericarditis.

                            Product Name : KPL-387

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            February 25, 2025

                            Lead Product(s) : KPL-387

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            CuraSen Therapeutics

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                            EPS
                            Not Confirmed

                            CuraSen Therapeutics

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                            EPS
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                            Lead Product(s) : CST-3056

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Study Phase : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            CuraSen Begins Phase 1 Trial of CuraAX for Alzheimer’s Disease

                            Details : CST-3056 (CuraAX), an alpha-1A adrenoceptor agonist, small molecule drug candidate, which is being evaluated for the treatment of neurogenic orthostatic hypotension.

                            Product Name : CST-3056

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            February 20, 2025

                            Lead Product(s) : CST-3056

                            Therapeutic Area : Cardiology/Vascular Diseases

                            Highest Development Status : Phase I

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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