Polpharma European CDMO Partner & API Manufacturer since 1951 Polpharma European CDMO Partner & API Manufacturer since 1951

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            Details:

            The company intends to use the net proceeds to fund the development of AR882, a highly potent and selective next-gen URAT1 inhibitor delivered in a once daily immediate release oral capsule, being developed for the treatment of gout.

            Lead Product(s): AR882

            Therapeutic Area: Rheumatology Product Name: AR882

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Guangrun Health Industry

            Deal Size: $75.0 million Upfront Cash: Undisclosed

            Deal Type: Series D Financing July 12, 2023

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            ABP-671 is a small molecule inhibitor of the urate transporter 1 (URAT1) protein, which is involved in the reabsorption of uric acid by the kidneys. In gout patients, ABP-671 reduces the reabsorption of uric acid, increasing its excretion in urine.

            Lead Product(s): ABP-671

            Therapeutic Area: Rheumatology Product Name: ABP-671

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 01, 2023

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            ABP-671 was well tolerated, with the overall incidence of treatment emergent adverse events similar between the ABP-671 treatment cohorts and the placebo cohorts.

            Lead Product(s): ABP-671

            Therapeutic Area: Rheumatology Product Name: ABP-671

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable November 10, 2022

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            Results from US Phase 2 clinical trial—primary end point set at a challenging level confirmed the potential of LC350189 (tigulixostat) as a new gout treatment distinguished from pre-existing drugs, while also demonstrating safety similar to that of the placebo group.

            Lead Product(s): Tigulixostat

            Therapeutic Area: Rheumatology Product Name: LC350189

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable August 03, 2022

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            Details:

            Topical application of DYV702 significantly reduced pain intensity and duration of acute gout flare with higher overall response rates, faster time to resolution, improvements in physical function and reduction in rescue medication use.

            Lead Product(s): DYV702,Colchicine

            Therapeutic Area: Rheumatology Product Name: DYV702

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable June 01, 2022

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            Details:

            The presentation demonstrated clinically meaningful improvement of TPX-100 in overall knee pain and in specific key pain parameters in moderate to severe knee OA, linked to significant reductions in pathological bone shape change.

            Lead Product(s): TPX-100

            Therapeutic Area: Rheumatology Product Name: TPX-100

            Highest Development Status: Phase II Product Type: Peptide

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable April 08, 2022

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            Details:

            Preliminary data suggest Atom’s compound ABP-671, a small molecule inhibitor of the urate transporter (URAT1) protein reduces uric acid levels to prevent gout flare-ups without the adverse side effects of existing treatments.

            Lead Product(s): ABP-671

            Therapeutic Area: Rheumatology Product Name: ABP-671

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 21, 2022

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            Details:

            Funding will support company’s anticipated global Phase III clinical trial of lead product, ABP-671, for treatment of hyperuricemia and gout, which affects more than 255 million people worldwide.

            Lead Product(s): ABP-671

            Therapeutic Area: Rheumatology Product Name: ABP-671

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Xicheng Jinrui Equity Investment Fund

            Deal Size: $45.0 million Upfront Cash: Undisclosed

            Deal Type: Series C Financing January 05, 2022

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