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    [{"orgOrder":0,"company":"Marea Therapeutics","sponsor":"ProBioGen","pharmaFlowCategory":"D","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Antibody","year":"2025","type":"Partnership","leadProduct":"MAR002","moa":"GHS receptor","graph1":"Endocrinology","graph2":"IND Enabling","graph3":"Marea Therapeutics","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Marea Therapeutics \/ ProBioGen","highestDevelopmentStatusID":"5","companyTruncated":"Marea Therapeutics \/ ProBioGen"},{"orgOrder":0,"company":"Vertex Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Cell and Gene therapy","year":"2023","type":"Inapplicable","leadProduct":"VX-264","moa":"Undisclosed","graph1":"Endocrinology","graph2":"IND Enabling","graph3":"Vertex Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Implant","sponsorNew":"Vertex Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Vertex Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Provention Bio","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Vaccine","year":"2020","type":"Inapplicable","leadProduct":"PRV-101","moa":"Undisclosed","graph1":"Endocrinology","graph2":"IND Enabling","graph3":"Provention Bio","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Provention Bio \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Provention Bio \/ Inapplicable"},{"orgOrder":0,"company":"Alnylam Pharmaceuticals","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"U.S.A","productType":"Oligonucleotide","year":"2022","type":"Inapplicable","leadProduct":"ALN-KHK","moa":"Ketohexokinase","graph1":"Endocrinology","graph2":"IND Enabling","graph3":"Alnylam Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Subcutaneous Injection","sponsorNew":"Alnylam Pharmaceuticals \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Alnylam Pharmaceuticals \/ Inapplicable"},{"orgOrder":0,"company":"Sernova","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"CANADA","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"Thyroid Cell","moa":"T3\/T4","graph1":"Endocrinology","graph2":"IND Enabling","graph3":"Sernova","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Sernova \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Sernova \/ Inapplicable"},{"orgOrder":0,"company":"Sernova","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Endocrinology","country":"CANADA","productType":"Cell and Gene therapy","year":"2025","type":"Inapplicable","leadProduct":"Undisclosed","moa":"T3\/T4","graph1":"Endocrinology","graph2":"IND Enabling","graph3":"Sernova","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Endocrinology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Sernova \/ Inapplicable","highestDevelopmentStatusID":"5","companyTruncated":"Sernova \/ Inapplicable"}]

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                            01

                            Marea Therapeutics

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                            Marea Therapeutics

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                            Lead Product(s) : MAR002

                            Therapeutic Area : Endocrinology

                            Study Phase : IND Enabling

                            Sponsor : ProBioGen

                            Deal Size : Undisclosed

                            Deal Type : Partnership

                            DEALS_DEV arrow-down

                            ProBioGen and Marea Therapeutics Accelerate MAR002 Antibody

                            Details : The parternship aims to deliver clinical material for MAR002, Marea’s investigational anti-growth hormone receptor (GHR) antibody for the treatment of acromegaly.

                            Product Name : MAR002

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            March 05, 2025

                            Lead Product(s) : MAR002

                            Therapeutic Area : Endocrinology

                            Highest Development Status : IND Enabling

                            Sponsor : ProBioGen

                            Deal Size : Undisclosed

                            Deal Type : Partnership

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                            02

                            Sernova

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                            EPS
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                            Sernova

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                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Endocrinology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sernova gets FDA IND Clearance for Cell Pouch with Autograft Thyroid Cells

                            Details : Company’s Cell Pouch with auto-transplanted thyroid cells is being evaluated in patients undergoing thyroid surgery for nodular thyroid disease.

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            March 03, 2025

                            Lead Product(s) : Undisclosed

                            Therapeutic Area : Endocrinology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Sernova

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                            Sernova

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                            Lead Product(s) : Thyroid Cell

                            Therapeutic Area : Endocrinology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Sernova Submits IND for Cell Pouch Bio-Hybrid Organ in Hypothyroidism

                            Details : Company’s Cell Pouch auto-transplanted with thyroid cells is being investigated for nodular thyroid disease. It restores thyroxine and triiodothyronine, to pre-thyroidectomy levels.

                            Product Name : Undisclosed

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            February 03, 2025

                            Lead Product(s) : Thyroid Cell

                            Therapeutic Area : Endocrinology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            SAB Biotherapeutics

                            U.S.A arrow
                            EPS
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                            SAB Biotherapeutics

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                            Lead Product(s) : SAB-142

                            Therapeutic Area : Endocrinology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            FDA Provides Clearance to IND Application for Type 1 Diabetes Therapy SAB-142 by SAB Bio

                            Details : SAB-142 is a human alternative to rabbit anti-thymocyte globulin, SAB-142’s mechanism of action is analogous to that of rabbit ATG, which is being clinically validated in the clinical trials for T1D.

                            Product Name : SAB-142

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            May 21, 2024

                            Lead Product(s) : SAB-142

                            Therapeutic Area : Endocrinology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            SAB Biotherapeutics

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                            EPS
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                            SAB Biotherapeutics

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                            Lead Product(s) : SAB-142

                            Therapeutic Area : Endocrinology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            SAB Biotherapeutics Receives Australian Approval to Commence Phase 1 Clinical Trial of SAB-142, a Potential Di...

                            Details : SAB-142 is the first fully-human anti-thymocyte hpAB therapeutic currently being developed for delaying the progression and onset of type 1 diabetes, among other autoimmune indications.

                            Product Name : SAB-142

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            October 19, 2023

                            Lead Product(s) : SAB-142

                            Therapeutic Area : Endocrinology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

                            SAB Biotherapeutics

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                            SAB Biotherapeutics

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                            Lead Product(s) : SAB-142

                            Therapeutic Area : Endocrinology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            SAB Biotherapeutics Successfully Concludes IND-Enabling GLP Toxicology Study for SAB-142, a Novel Immunotherap...

                            Details : SAB-142 is the first fully-human anti-thymocyte hpAB therapeutic currently being developed for delaying the progression and onset of type 1 diabetes, among other autoimmune indications.

                            Product Name : SAB-142

                            Product Type : Antibody

                            Upfront Cash : Inapplicable

                            October 01, 2023

                            Lead Product(s) : SAB-142

                            Therapeutic Area : Endocrinology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Vertex Pharmaceuticals

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                            EPS
                            Not Confirmed

                            Vertex Pharmaceuticals

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                            Lead Product(s) : VX-264

                            Therapeutic Area : Endocrinology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Vertex Announces FDA Clearance of Investigational New Drug Application for VX-264, a Novel Encapsulated Cell T...

                            Details : VX-264 is an investigational cell therapy in which allogeneic human stem cell-derived islets are encapsulated in a channel array device designed to shield the cells from the body’s immune system. It is currently being evaluated for patients with T1D.

                            Product Name : VX-264

                            Product Type : Cell and Gene therapy

                            Upfront Cash : Inapplicable

                            September 03, 2023

                            Lead Product(s) : VX-264

                            Therapeutic Area : Endocrinology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            MBX Biosciences

                            U.S.A arrow
                            EPS
                            Not Confirmed

                            MBX Biosciences

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                            Lead Product(s) : MBX 1416

                            Therapeutic Area : Endocrinology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            MBX Biosciences Announces U.S. FDA Clearance of IND Application for MBX 1416 for the Treatment of Post-Bariatr...

                            Details : MBX 1416 is an investigational long-acting GLP-1 receptor antagonist in development as a potential treatment for Post-Bariatric Hypoglycemia. It was designed using the company’s novel, proprietary PEP platform to prevent the occurrence of severe hypogl...

                            Product Name : MBX 1416

                            Product Type : Hormone

                            Upfront Cash : Inapplicable

                            July 08, 2023

                            Lead Product(s) : MBX 1416

                            Therapeutic Area : Endocrinology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Biomea Fusion

                            U.S.A arrow
                            EPS
                            Not Confirmed

                            Biomea Fusion

                            U.S.A arrow
                            EPS
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                            Lead Product(s) : BMF-219

                            Therapeutic Area : Endocrinology

                            Study Phase : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Biomea Fusion Announces FDA Clearance of Investigational New Drug (IND) Application for BMF-219 in Type 1 Diab...

                            Details : BMF-219 is a novel covalent menin inhibitor designed to regenerate insulin-producing beta cells with the aim to cure type 1 diabetes. The FDA has cleared the initiation of COVALENT-112, a Phase II clinical trial.

                            Product Name : BMF-219

                            Product Type : Other Small Molecule

                            Upfront Cash : Inapplicable

                            May 10, 2023

                            Lead Product(s) : BMF-219

                            Therapeutic Area : Endocrinology

                            Highest Development Status : IND Enabling

                            Sponsor : Inapplicable

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            SAB Biotherapeutics

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                            EPS
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                            SAB Biotherapeutics

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                            Lead Product(s) : SAB-142

                            Therapeutic Area : Endocrinology

                            Study Phase : IND Enabling

                            Sponsor : RA Capital Management

                            Deal Size : $130.0 million

                            Deal Type : Private Placement

                            DEALS_DEV arrow-down

                            SAB Biotherapeutics Announces Private Placement of up to $130 Million to Advance Development of Lead Drug Cand...

                            Details : SAB will use the funds to clinically advance SAB-142, a fully-human alternative to rabbit anti-thymocyte globulin (rATG), its lead therapeutic candidate for type 1 diabetes (T1D).

                            Product Name : SAB-142

                            Product Type : Antibody

                            Upfront Cash : Undisclosed

                            February 10, 2023

                            Lead Product(s) : SAB-142

                            Therapeutic Area : Endocrinology

                            Highest Development Status : IND Enabling

                            Sponsor : RA Capital Management

                            Deal Size : $130.0 million

                            Deal Type : Private Placement

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