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Odimma will gain access to Touchlight’s proprietary doggybone DNA (dbDNA™) vector technology, providing them with a clinical supply of personalised dbDNA™, to support and underpin the development of their candidate immunotherapy cancer treatment.
The research collaboration is based on new innovations to improve the structure of the CAR T-cell product. In CAR T-cell therapy, the patient's own white blood cells are genetically modified to attack the cancer and kill it.
The alliance will combine MD Anderson’s clinical trials infrastructure and Sanofi’s pipeline of investigational treatments to lead biomarker-driven clinical studies to better understand how novel cancer drugs work.
The collaboration focuses on the development of first-in-class targeted immune-based therapies for oncology. The collaboration leverages Evotec’s integrated discovery and development capabilities and manufacturing optimisation processes.
Sanofi is licensing a Natural Killer (NK) cell engager program for cancer targeting B7H3 from Innate’s ANKET® (Antibody-based NK Cell Engager Therapeutics) platform. Sanofi will also have the option to add up to two additional ANKET® targets.
Under the terms of the agreement, acquisition of multiple research-stage DNA damage response (DDR) programs identified using KSQ’s CRISPRomics platform technology will advance identification of novel oncology targets and develop potential first-in-class programs.
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