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Details:
Proceeds from financing will be used to advance lead programs, including GSBR-1290 in clinical investigation and expand application of its next generation structure-based drug discovery platform to drive innovations in G-protein coupled receptor targeted therapies.
Lead Product(s):
GSBR-1290
Therapeutic Area: Endocrinology
Product Name: GSBR-1290
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Deep Track Capital
Deal Size: $133.0 million
Upfront Cash: Undisclosed
Deal Type: Series B Financing
August 01, 2022
Details:
The funding will support the phase 2 studies for CT-388, a dual modulator of the GLP-1 and GIP incretin receptors, phase 1 studies for CT-996, an oral small molecule GLP-1 receptor agonist, and phase 2 studies for CT-868, a first-inclass fully biased GLP-1/GIP modulator.
Lead Product(s):
CT-388
Therapeutic Area: Endocrinology
Product Name: CT-388
Highest Development Status: Phase I
Product Type: Peptide
Partner/Sponsor/Collaborator:
The Column Group
Deal Size: $160.0 million
Upfront Cash: Undisclosed
Deal Type: Series D Financing
July 26, 2022
Details:
MBX 2109, an investigational PTH prodrug in development designed with novel, proprietary prodrug to provide sustained PTH activity with dosing regimen to simplify an individual’s disease management, while relieving both symptoms of disorder and long-term complications.
Lead Product(s):
MBX 2109
Therapeutic Area: Endocrinology
Product Name: MBX 2109
Highest Development Status: Phase I
Product Type: Peptide
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
July 26, 2022
Details:
PKX-001 is the designation given to the lead drug product molecule of the Antiaging Glycopeptide family. Islet cell transplants are well recognized as a viable and effective treatment for Type-1 diabetes.
Lead Product(s):
Antiaging Glycopeptide
Therapeutic Area: Endocrinology
Product Name: PKX-001
Highest Development Status: Phase I
Product Type: Peptide
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
July 20, 2022
Details:
BMF-219 showed prolonged glycemic control in two standard diabetes animal models, the Zucker Diabetic Fatty (ZDF) and Streptozotocin-induced (STZ) Rat models, throughout the dosing period and, additionally, glycemic control was maintained after the dosing period ended.
Lead Product(s):
BMF-219
Therapeutic Area: Endocrinology
Product Name: BMF-219
Highest Development Status: Phase I
Product Type: Small molecule
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
July 01, 2022
Details:
Data from 18 subjects that completed all three hypoglycemic challenge (clamp) procedures demonstrated that nearly 90% of subjects had a meaningful increase in glucagon following ZT-01 compared to placebo.
Lead Product(s):
ZT-01
Therapeutic Area: Endocrinology
Product Name: ZT-01
Highest Development Status: Phase I
Product Type: Peptide
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
June 22, 2022
Details:
Proceeds from the transaction are expected to provide Zura Bio with the capital needed to accelerate the development of ZB-168, a fully-human, clinical-stage antibody targeting IL7Rα, that was recently in-licensed from Pfizer Inc.
Lead Product(s):
ZB-168
Therapeutic Area: Endocrinology
Product Name: ZB-168
Highest Development Status: Phase I
Product Type: Large molecule
Partner/Sponsor/Collaborator:
Zura Bio
Deal Size: Undisclosed
Upfront Cash: $65.0 million
Deal Type: Merger
June 17, 2022
Details:
Dapiglutide (pINN) is a long-acting GLP-1R/GLP-2R dual agonist. Results showed a plasma half-life allowing for once weekly dosing and effects on several biomarkers suggest clinically relevant exposures of ZP7570 were achieved.
Lead Product(s):
Dapiglutide
Therapeutic Area: Endocrinology
Product Name: ZP7570
Highest Development Status: Phase I
Product Type: Peptide
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
June 06, 2022
Details:
ZP7570 (dapiglutide), a novel GLP1/GLP2 dual agonist and preclinical data on the antidiabetic potential of the company’s long-acting amylin analogue ZP8396.
Lead Product(s):
Dapiglutide
Therapeutic Area: Endocrinology
Product Name: ZP7570
Highest Development Status: Phase I
Product Type: Peptide
Partner/Sponsor/Collaborator:
Boehringer Ingelheim GmbH
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
May 31, 2022
Details:
ORMD 0901 is an Oral GLP-1 for T2DM, is an incretin hormone that stimulates the secretion of insulin from the pancreas, significantly increase compliance and become a valuable tool in the treatment of diabetes.
Lead Product(s):
ORMD-0901,Insulin
Therapeutic Area: Endocrinology
Product Name: ORMD-0901
Highest Development Status: Phase I
Product Type: Peptide
Partner/Sponsor/Collaborator:
Not Applicable
Deal Size: Not Applicable
Upfront Cash: Not Applicable
Deal Type: Not Applicable
May 24, 2022
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