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    Chemistry

    Click the arrow to open the dropdown
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    Also known as: 274693-27-5, Brilinta, Brilique, Azd6140, Azd-6140, Possia
    Molecular Formula
    C23H28F2N6O4S
    Molecular Weight
    522.6  g/mol
    InChI Key
    OEKWJQXRCDYSHL-FNOIDJSQSA-N
    FDA UNII
    GLH0314RVC
    Ticagrelor
    An adenosine triphosphate analogue and reversible P2Y12 PURINORECEPTOR antagonist that inhibits ADP-mediated PLATELET AGGREGATION. It is used for the prevention of THROMBOEMBOLISM by patients with ACUTE CORONARY SYNDROME or a history of MYOCARDIAL INFARCTION.
    Ticagrelor is a P2Y12 Platelet Inhibitor. The mechanism of action of ticagrelor is as a Phenylalanine Hydroxylase Activator, and P2Y12 Receptor Antagonist, and Cytochrome P450 3A4 Inhibitor, and Cytochrome P450 3A5 Inhibitor, and P-Glycoprotein Inhibitor. The physiologic effect of ticagrelor is by means of Decreased Platelet Aggregation.
    1 2D Structure

    Ticagrelor

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    (1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
    2.1.2 InChI
    InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1
    2.1.3 InChI Key
    OEKWJQXRCDYSHL-FNOIDJSQSA-N
    2.1.4 Canonical SMILES
    CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F
    2.1.5 Isomeric SMILES
    CCCSC1=NC(=C2C(=N1)N(N=N2)[C@@H]3C[C@@H]([C@H]([C@H]3O)O)OCCO)N[C@@H]4C[C@H]4C5=CC(=C(C=C5)F)F
    2.2 Other Identifiers
    2.2.1 UNII
    GLH0314RVC
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. 3-(7-((2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-(1-3)-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    2. Azd 6140

    3. Azd-6140

    4. Azd6140

    5. Brilinta

    6. Brilique

    2.3.2 Depositor-Supplied Synonyms

    1. 274693-27-5

    2. Brilinta

    3. Brilique

    4. Azd6140

    5. Azd-6140

    6. Possia

    7. Ar-c126532xx

    8. Azd 6140

    9. Ticargrelor

    10. [14c]-ticagrelor

    11. Glh0314rvc

    12. (1s,2s,3r,5s)-3-(7-(((1r,2s)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    13. Chebi:68558

    14. (1s,2s,3r,5s)-3-(7-((1r,2s)-2-(3,4-difluorophenyl)cyclopropylamino)-5-(propylthio)-3h-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    15. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3h-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol

    16. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    17. 1,2-cyclopentanediol, 3-(7-(((1r,2s)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)-, (1s,2s,3r,5s)-

    18. (1s,2s,3r,5s)-3-(7-((1r,2s)-2-(3,4-difluorophenyl)cyclopropylamino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    19. (1s,2s,3r,5s)-3-[7-[(1r,2s)-2-(3,4-difluorophenyl)cyclopropylamino]-5-(propylthio)- 3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    20. Ticagrelor [usan]

    21. Unii-glh0314rvc

    22. Ticagrelor [usan:inn:ban]

    23. C23h28f2n6o4s

    24. Ar-c 126532xx

    25. Brilinta (tn)

    26. (1s,2s,3r,5s)-3-(7-(((1r)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    27. (1s,2s,3r,5s)-3-(7-{[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylsulfanyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    28. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    29. (1s,2s,3r,5s)-3-[7-{[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylsulfanyl)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    30. Ticagrelor- Bio-x

    31. Ar-c126532

    32. Ticagrelor [mi]

    33. Ticagrelor [inn]

    34. Ticagrelor [jan]

    35. Ticagrelor [vandf]

    36. Ticagrelor [mart.]

    37. Ticagrelor [usp-rs]

    38. Ticagrelor [who-dd]

    39. Ticagrelor (jan/usan/inn)

    40. Ticagrelor [ema Epar]

    41. Chembl398435

    42. Gtpl1765

    43. Schembl1979652

    44. Ticagrelor [orange Book]

    45. Ammd00027

    46. Hsdb 8306

    47. Ex-a503

    48. Ticagrelor (brilinta,azd6140)

    49. Ticagrelor [ep Monograph]

    50. Dtxsid901009337

    51. Hms3885b03

    52. Bdbm50397205

    53. Mfcd09954148

    54. S4079

    55. Zinc28957444

    56. Akos015900739

    57. Am85693

    58. Ccg-269870

    59. Cs-0619

    60. Db08816

    61. Ex-6274

    62. Ar-c 126532xx;azd6140

    63. Compound 17 [pmid: 17827008]

    64. Ncgc00379052-01

    65. Ncgc00379052-02

    66. Ac-24755

    67. As-19943

    68. Bt164470

    69. Hy-10064

    70. D09017

    71. Ab01565855_02

    72. 693t275

    73. A850981

    74. Q420542

    75. J-016772

    76. J-524969

    77. (1s,2s,3r,5s)-3-(7-(((1s,2s)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    78. (1s,2s,3r,5s)-3-(7-((1r,2s)-2-(3,4-difluorophenyl)cyclopropylamino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy) Cyclopentane-1,2-diol

    79. (1s,2s,3r,5s)-3-(7-((1r,2s)-2-(3,4-difluorophenyl)cyclopropylamino)-5-(propylthio)-3h-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2 Diol

    80. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-d1,2-cyclopentanediolifluorophenyl)cyclopropyl]amino]-5-(propylthio)-3h-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol

    81. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)-cyclopropyl]amino]-5-(propylthio)-3h-[1,2,3]-triazolo[4,5-d]pyrimidine-3-yl]-5-(2-hydroxyethoxy) Cyclopentane-1,2-diol

    82. (1s,2s,3r,5s)-3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-propylsulfanyltriazolo[5,4-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)cyclopentane-1,2-diol

    83. 1,2-cyclopentanediol,3-[7-[[(1r,2s)-2-(3,4-difluorophenyl)cyclopropyl]amino]-5-(propylthio)-3h-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-,(1s,2s,3r,5s)-

    2.4 Create Date
    2006-10-25
    3 Chemical and Physical Properties
    Molecular Weight 522.6 g/mol
    Molecular Formula C23H28F2N6O4S
    XLogP32
    Hydrogen Bond Donor Count4
    Hydrogen Bond Acceptor Count12
    Rotatable Bond Count10
    Exact Mass522.18608089 g/mol
    Monoisotopic Mass522.18608089 g/mol
    Topological Polar Surface Area164 Ų
    Heavy Atom Count36
    Formal Charge0
    Complexity736
    Isotope Atom Count0
    Defined Atom Stereocenter Count6
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 2  
    Drug NameBrilinta
    PubMed HealthTicagrelor (By mouth)
    Drug ClassesPlatelet Aggregation Inhibitor
    Drug LabelBRILINTA contains ticagrelor, a cyclopentyltriazolopyrimidine, inhibitor of platelet activation and aggregation mediated by the P2Y12 ADP-receptor. Chemically it is (1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-...
    Active IngredientTicagrelor
    Dosage FormTablet
    RouteOral
    Strength90mg
    Market StatusPrescription
    CompanyAstrazeneca

    2 of 2  
    Drug NameBrilinta
    PubMed HealthTicagrelor (By mouth)
    Drug ClassesPlatelet Aggregation Inhibitor
    Drug LabelBRILINTA contains ticagrelor, a cyclopentyltriazolopyrimidine, inhibitor of platelet activation and aggregation mediated by the P2Y12 ADP-receptor. Chemically it is (1S,2S,3R,5S)-3-[7-{[(1R,2S)-2-(3,4-difluorophenyl)cyclopropyl]amino}-5-(propylthio)-...
    Active IngredientTicagrelor
    Dosage FormTablet
    RouteOral
    Strength90mg
    Market StatusPrescription
    CompanyAstrazeneca

    4.2 Therapeutic Uses

    Purinergic P2Y Receptor Antagonists

    National Library of Medicine's Medical Subject Headings. Ticagrelor. Online file (MeSH, 2016). Available from, as of January 20, 2016: https://www.nlm.nih.gov/mesh/2016/mesh_browser/MBrowser.html

    /CLINICAL TRIALS/ ClinicalTrials.gov is a registry and results database of publicly and privately supported clinical studies of human participants conducted around the world. The Web site is maintained by the National Library of Medicine (NLM) and the National Institutes of Health (NIH). Each ClinicalTrials.gov record presents summary information about a study protocol and includes the following: Disease or condition; Intervention (for example, the medical product, behavior, or procedure being studied); Title, description, and design of the study; Requirements for participation (eligibility criteria); Locations where the study is being conducted; Contact information for the study locations; and Links to relevant information on other health Web sites, such as NLM's MedlinePlus for patient health information and PubMed for citations and abstracts for scholarly articles in the field of medicine. Ticagrelor is included in the database.

    NIH/NLM; ClinicalTrials.Gov. Available from, as of March 17, 2016: https://clinicaltrials.gov/ct2/results?term=ticagrelor&Search=Search

    Brilinta is indicated to reduce the rate of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome (ACS) or a history of myocardial infarction (MI). For at least the first 12 months following ACS, it is superior to clopidogrel. /Included in US product label/

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 20, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    Brilinta also reduces the rate of stent thrombosis in patients who have been stented for treatment of acute coronary syndrome (ACS). /Included in US product label/

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 20, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    4.3 Drug Warning

    /BOXED WARNING/ BLEEDING RISK. Brilinta, like other antiplatelet agents, can cause significant, sometimes fatal bleeding. Do not use Brilinta in patients with active pathological bleeding or a history of intracranial hemorrhage. Do not start Brilinta in patients undergoing urgent coronary artery bypass graft surgery (CABG). If possible, manage bleeding without discontinuing Brilinta. Stopping Brilinta increases the risk of subsequent cardiovascular events

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 27, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    /BOXED WARNING/ ASPIRIN DOSE AND BRILINTA EFFECTIVENESS. Maintenance doses of aspirin above 100 mg reduce the effectiveness of Brilinta and should be avoided.

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 27, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    In general, treatment with ticagrelor should not be discontinued prematurely because this increases the risk of cardiovascular events. Premature discontinuance of antiplatelet therapy (e.g., P2Y12 adenosine diphosphate (ADP)-receptor antagonists, aspirin) in patients with coronary artery stents has been associated with an increased risk of ischemic cardiovascular events (e.g., stent thrombosis, myocardial infarction (MI), death). If temporary discontinuance of ticagrelor is necessary such as prior to elective surgery or for management of bleeding, the drug should be restarted as soon as possible. Patients should be advised to never stop taking ticagrelor without first consulting the prescribing clinician, even if instructed by another clinician (e.g., dentist) to stop such therapy. Prior to scheduling an invasive procedure, patients should inform clinicians (including dentists) that they are currently taking ticagrelor and clinicians performing the invasive procedure should consult with the prescribing clinician before discontinuing such therapy.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1546-7

    Bradyarrhythmias, including ventricular pauses, have occurred in patients receiving ticagrelor. In the The Study of Platelet Inhibition and Patient Outcomes (PLATO) study, Holter monitor-detected ventricular pauses of at least 3 seconds were reported more frequently during the first week of therapy in patients receiving ticagrelor than in those receiving clopidogrel (5.8 versus 3.6%, respectively). There was no difference in the overall risk of clinically important bradycardic effects (e.g., syncope, need for pacemaker insertion) between the treatment groups. Ventricular pauses were mostly asymptomatic and attributed to sinoatrial nodal suppression. Patients with a baseline increased risk of bradycardia (e.g., those with sick sinus syndrome, second- or third-degree AV block, syncope due to bradycardia without a pacemaker) were excluded from the PLATO study; therefore, some clinicians recommend that ticagrelor be used with caution in such patients.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1547

    For more Drug Warnings (Complete) data for Ticagrelor (15 total), please visit the HSDB record page.

    4.4 Drug Indication

    Ticagrelor is indicated to reduce the risk of cardiovascular death, myocardial infarction, and stroke in patients with acute coronary syndrome or a history of myocardial infarction. Ticagrelor is also indicated to reduce the risk of a first myocardial infarction or stroke in high risk patients with coronary artery disease.

    FDA Label

    Brilique, co administered with acetylsalicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with

    - acute coronary syndromes (ACS) or

    - a history of myocardial infarction (MI) and a high risk of developing an atherothrombotic event

    Brilique, co-administered with acetyl salicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with a history of myocardial infarction (MI occurred at least one year ago) and a high risk of developing an atherothrombotic event.

    Possia, co-administered with acetylsalicylic acid (ASA), is indicated for the prevention of atherothrombotic events in adult patients with acute coronary syndromes (unstable angina, non-ST-elevation myocardial infarction [NSTEMI] or ST-elevation myocardial infarction [STEMI]); including patients managed medically, and those who are managed with percutaneous coronary intervention (PCI) or coronary artery by-pass grafting (CABG).

    Prevention of thromboembolic events

    5 Pharmacology and Biochemistry
    5.1 Pharmacology

    Ticagrelor is a P2Y12 receptor antagonist that inhibits the formation of thromboses to reduce the risk of myocardial infarction and ischemic stroke. It has a moderate duration of action as it is given twice daily, and a wide therapeutic index as high single doses are well tolerated. Patients should be counselled regarding the risk of bleeding, dyspnea, and bradyarrhythmias.

    5.2 MeSH Pharmacological Classification

    Platelet Aggregation Inhibitors

    Drugs or agents which antagonize or impair any mechanism leading to blood platelet aggregation, whether during the phases of activation and shape change or following the dense-granule release reaction and stimulation of the prostaglandin-thromboxane system. (See all compounds classified as Platelet Aggregation Inhibitors.)

    Purinergic P2Y Receptor Antagonists

    Compounds that bind to and block the stimulation of PURINERGIC P2Y RECEPTORS. Included under this heading are antagonists for specific P2Y receptor subtypes. (See all compounds classified as Purinergic P2Y Receptor Antagonists.)

    5.3 FDA Pharmacological Classification
    5.3.1 Active Moiety
    TICAGRELOR
    5.3.2 FDA UNII
    GLH0314RVC
    5.3.3 Pharmacological Classes
    Cytochrome P450 3A5 Inhibitors [MoA]; Decreased Platelet Aggregation [PE]; P-Glycoprotein Inhibitors [MoA]; P2Y12 Platelet Inhibitor [EPC]; P2Y12 Receptor Antagonists [MoA]; Phenylalanine Hydroxylase Activators [MoA]; Cytochrome P450 3A4 Inhibitors [MoA]
    5.4 ATC Code

    B01AC24

    B01AC24

    B01AC24

    S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355

    B - Blood and blood forming organs

    B01 - Antithrombotic agents

    B01A - Antithrombotic agents

    B01AC - Platelet aggregation inhibitors excl. heparin

    B01AC24 - Ticagrelor

    5.5 Absorption, Distribution and Excretion

    Absorption

    Ticagrelor is 36% orally bioavailable. A single 200mg oral dose of ticagrelor reaches a Cmax of 923ng/mL, with a Tmax of 1.5 hours and an AUC of 6675ng\*h/mL. The active metabolite of ticagrelor reaches a Cmax of 264ng/mL, with a Tmax of 3.0 hours and an AUC of 2538ng\*h/mL.

    Route of Elimination

    A radiolabelled dose of ticagrelor is 57.8% recovered in feces and 26.5% recovered in urine. Less than 1% of the dose is recovered as the unmetabolized parent drug. The active metabolite AC-C124910XX makes up 21.7% of the recovery in the feces. The metabolite AR-C133913XX makes up 9.2% of the recovery in the urine and 2.7% of the recovery in the feces. Other minor metabolites are predominantly recovered in the urine.

    Volume of Distribution

    The steady state volume of distribution of ticagrelor is 88 L.

    Clearance

    The renal clearance of ticagrelor is 0.00584L/h.

    The drug is metabolized principally by cytochrome P-450 (CYP) isoenzyme 3A4 to an active metabolite that has similar antiplatelet activity as the parent drug.Plasma concentrations of ticagrelor and its active metabolite increase in a dose-dependent manner with peak concentrations achieved within approximately 1.5 and 2.5 hours, respectively. Ticagrelor is primarily eliminated in the feces and to a lesser extent in urine; less than 1% of a dose is recovered in urine as the parent drug and active metabolite. ... Both ticagrelor and its active metabolite are extensively (more than 99%) bound to human plasma proteins. Administration with a high-fat meal increases systemic exposure of ticagrelor by 21% and decreases peak plasma concentrations of the active metabolite by 22%, but has no effect on peak plasma concentrations of ticagrelor or on systemic exposure to the active metabolite.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1548

    Ticagrelor is rapidly absorbed following oral administration.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1548

    The primary route of ticagrelor elimination is hepatic metabolism. When radiolabeled ticagrelor is administered, the mean recovery of radioactivity is approximately 84% (58% in feces, 26% in urine). Recoveries of ticagrelor and the active metabolite in urine were both less than 1% of the dose. The primary route of elimination for the major metabolite of ticagrelor is most likely to be biliary secretion.

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 27, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    /MILK/ It is not known whether ticagrelor or its active metabolites are excreted in human milk. Ticagrelor is excreted in rat milk.

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 27, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    For more Absorption, Distribution and Excretion (Complete) data for Ticagrelor (6 total), please visit the HSDB record page.

    5.6 Metabolism/Metabolites

    The complete structure of all ticagrelor metabolites are not well defined. Ticagrelor can be dealkylated at postition 5 of the cyclopentane ring to form the active AR-C124910XX. AR-C124910XX's cyclopentane ring can be further glucuronidated or the alkyl chain attached to the sulfur can be hydroxylated. Ticagrelor can also be glucuronidated or hydroxylated. Ticagrelor can also be N-dealkylated to form AR-C133913XX, which is further glucuronidated or hydroxylated.

    CYP3A4 is the major enzyme responsible for ticagrelor metabolism and the formation of its major active metabolite. Ticagrelor and its major active metabolite are weak P-glycoprotein substrates and inhibitors. The systemic exposure to the active metabolite is approximately 30-40% of the exposure of ticagrelor.

    NIH; DailyMed. Current Medication Information for Brilinta (Ticagrelor) Tablet (Updated: September 2015). Available from, as of January 27, 2016: https://dailymed.nlm.nih.gov/dailymed/drugInfo.cfm?setid=f7b3f443-e83d-4bf2-0e96-023448fed9a8

    The drug is metabolized principally by cytochrome P-450 (CYP) isoenzyme 3A4 to an active metabolite that has similar antiplatelet activity as the parent drug.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1548

    Ticagrelor is a reversibly binding oral P2Y(12) receptor antagonist in development for the prevention of thrombotic events in patients with acute coronary syndromes. The pharmacokinetics, metabolism, and excretion of ticagrelor were investigated over 168 hr in six healthy male subjects receiving a single oral suspension dose of 200 mg of (14)C-ticagrelor. ... Major circulating components in the plasma and feces were identified as ticagrelor and AR-C124910XX, whereas in urine the major components were metabolite M5 (AR-C133913XX) and its glucuronide conjugate M4. Levels of unchanged ticagrelor and AR-C124910XX were <0.05% in the urine, indicating that renal clearance of ticagrelor and AR-C124910XX is of minor importance. Interindividual variability was small in both urine and fecal extracts with only small quantitative differences. All 10 of the metabolites were fully or partially characterized and a full biotransformation pathway was proposed for ticagrelor, in which oxidative loss of the hydroxyethyl side chain from ticagrelor forms AR-C124910XX and a second oxidative pathway leads to N-dealkylation of ticagrelor, forming AR-C133913XX.

    PMID:20551239 Teng R et al; Drug Metab Dispos 38 (9): 1514-21 (2010)

    5.7 Biological Half-Life

    Ticagrelor has a plasma half life of approximately 8 hours, while the active metabolite has a plasma half life of approximately 12 hours.

    The mean terminal half-lives of ticagrelor and its active metabolite reportedly are about 7 and 9 hours, respectively.

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1548

    Ticagrelor is a reversibly binding oral P2Y(12) receptor antagonist in development for the prevention of thrombotic events in patients with acute coronary syndromes. The pharmacokinetics, metabolism, and excretion of ticagrelor were investigated over 168 hr in six healthy male subjects receiving a single oral suspension dose of 200 mg of (14)C-ticagrelor. In most subjects, radioactivity was undetectable in plasma after 20 hr and whole blood after 12 hr (half-life values of 6.3 and 4.6 hr, respectively).

    PMID:20551239 Teng R et al; Drug Metab Dispos 38 (9): 1514-21 (2010)

    5.8 Mechanism of Action

    Ticagrelor is a P2Y12 receptor antagonist. The P2Y12 receptor couples with Gi2 and other Gi proteins which inhibit adenylyl cyclase. Gi mediated signalling also activates PI3K, Akt, Rap1b, and potassium channels. The downstream effects of these activities mediate hemostasis and lead to platelet aggregation. Antagonism of the P2Y12 receptor reduces development of occlusive thromboses, which can reduce the risk of myocardial infarction and ischemic stroke.

    Ticagrelor, a cyclopentyltriazolopyrimidine derivative, is a nonthienopyridine, P2Y12 platelet adenosine diphosphate (ADP)-receptor antagonist. In contrast to the thienopyridines (e.g., clopidogrel, prasugrel), ticagrelor binds reversibly to the P2Y12 ADP receptor and does not require hepatic transformation to exert its pharmacologic effect. Ticagrelor exhibits noncompetitive and reversible binding to the P2Y12 platelet ADP receptor, preventing signal transduction of the cyclic adenosine monophosphate (cAMP) pathway. This results in reduced exposure of fibrinogen binding sites to the platelet glycoprotein (GP) IIb/IIIa complex and subsequent inhibition of platelet activation and aggregation. In addition to platelet ADP-receptor blockade, ticagrelor inhibits reuptake of adenosine into erythrocytes, a mechanism that may account for some of the beneficial cardiovascular effects of the drug, while potentially contributing to some of its adverse effects (e.g., dyspnea, ventricular pauses).

    American Society of Health-System Pharmacists 2015; Drug Information 2015. Bethesda, MD. 2015, p. 1547

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    Date of Issue : 2022-06-08

    Valid Till : 2025-06-16

    Written Confirmation Number : WC-0037

    Address of the Firm : Unit-II, Plot No.92-94, 257-259, IDA Pashmylaram, Isnapur Village, Patancheru Ma...

    Neuland

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    04

    Neuland Laboratories

    India
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    CPhI North America
    Booth #404
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    Virtual BoothNeuland Laboratories- A dedicated 100% API provider.

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    Ticagrelor IH

    Date of Issue : 2022-06-08

    Valid Till : 2025-06-16

    Written Confirmation Number : WC-0037

    Address of the Firm : Unit-II, Plot No.92-94, 257-259, IDA Pashmylaram, Isnapur Village, Patancheru Ma...

    Neuland

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    05

    TAPI Technology & API Services

    Israel
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    CPhI Japan
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    Virtual BoothTAPI, a leading global supplier of APIs, provides over 350 products and customized CDMO solutions for every stage of development.

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    Ticagrelor IH

    Date of Issue : 2022-06-22

    Valid Till : 2025-05-20

    Written Confirmation Number : WC-0001

    Address of the Firm : Q-1-4,Industrial area ,Ghinrongi Malanpur -477 117, Dist -Bhind (MP)

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    06

    Alembic Pharmaceuticals Limited

    India
    BePharma
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    Alembic Pharmaceuticals Limited

    India
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    Not Confirmed
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Ticagrelor (IH)

    Date of Issue : 2022-06-17

    Valid Till : 2025-07-02

    Written Confirmation Number : WC-0082

    Address of the Firm : API Division Kharakhadi, Plot No. 842-843, Kharakhadi, Padra Vadodara-391 450, G...

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    07

    Alivus Life Sciences

    India
    BePharma
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    Alivus Life Sciences

    India
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    BePharma
    Not Confirmed
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Ticagrelor IH

    Date of Issue : 2023-12-28

    Valid Till : 2026-12-28

    Written Confirmation Number : WC-0310

    Address of the Firm : Plot No. Z-103/l, Dahej SEZ, Phase ll, Dahej, Dist-Bharuch, Gujarat

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    08

    Arene Lifesciences

    India
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    Arene Lifesciences

    India
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    BePharma
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Ticagrelor IHS

    Date of Issue : 2023-12-26

    Valid Till : 2026-03-12

    Written Confirmation Number : WC-0487

    Address of the Firm : M/s Arene Life Sciences Private Limited 2 6 bol 08\r\nPlot No. 48-50, 209-211, I...

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    09

    Cipla

    India
    BePharma
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    Cipla

    India
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    BePharma
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    Ticagrelor IH

    Date of Issue : 2022-06-17

    Valid Till : 2025-08-04

    Written Confirmation Number : WC-0142n

    Address of the Firm : Plot. A-33, A-37/2/2 MIDC, Patalganga-410 220, Dist. Raigad, Maharashtra

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    10

    HONOUR LAB LTD

    India
    BePharma
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    HONOUR LAB LTD

    India
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    BePharma
    Not Confirmed
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    Ticagrelor (IH)

    Date of Issue : 2019-07-26

    Valid Till : 2022-05-05

    Written Confirmation Number : WC-0362

    Address of the Firm : Unit-III Plot No.4 Hetero Infrastructure SEZ N.Narasapuram Village, Nakkapally m...

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    01

    Polpharma

    Poland
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    Ce BioForum
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    Virtual BoothPolpharma is a Polish CDMO of APIs and a significant European API producer, delivering products to companies worldwide.

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    Tikagreller

    Registrant Name : 아이엠씨디코리아주식회사

    Registration Date : 2021-11-04

    Registration Number : Su172-7-ND

    Manufacturer Name : Pharmaceutical Works Polphar...

    Manufacturer Address : 19, Pelplinska Street., 83-200 Starogard Gdanski, Poland

    Polpharma CB

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    02

    Polpharma

    Poland
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    Ce BioForum
    Attending
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    Virtual BoothPolpharma is a Polish CDMO of APIs and a significant European API producer, delivering products to companies worldwide.

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    Registrant Name : 아이엠씨디코리아주식회사

    Registration Date : 2021-01-13

    Registration Number : Su172-6-ND

    Manufacturer Name : Zakłady Farmaceutyczne Polp...

    Manufacturer Address : ul. Peplińska 19, 83-200 Starogard Gdański, POLAND

    Polpharma CB

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    03

    Cohance Lifesciences

    India
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    BePharma
    Not Confirmed
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    Virtual BoothCohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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    Registrant Name : Aging Life Science Co., Ltd.

    Registration Date : 2020-09-29

    Registration Number : 434-23-ND

    Manufacturer Name : ZCL Chemicals Limited

    Manufacturer Address : Plot No. 3102/B GIDC, Industrial Estate Ankleshwar, City : Ankleshwar - 393 002, Dist...

    Cohance

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    04

    Dr. Reddy's Laboratories

    India
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    CPhI Japan
    Booth #5N-12
    • fda
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    Registrant Name : Sangjin Corporation

    Registration Date : 2017-04-03

    Registration Number : Su583-25-ND

    Manufacturer Name : Dr. Reddy's Laboratories Lim...

    Manufacturer Address : APIIC Industrial Estate, Pydibhimavaram(V), Ranasthalam Mandal, Srikakulam-District 5...

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    05

    Dr. Reddy's Laboratories

    India
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    CPhI Japan
    Booth #5N-12
    • fda
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    Registrant Name : Hwail Pharmaceutical Co., Ltd.

    Registration Date : 2017-11-27

    Registration Number : No. 583-25-ND(1)

    Manufacturer Name : Dr. Reddy's Laboratories Lim...

    Manufacturer Address : APIIC Industrial Estate, Pydibhimavaram(V), Ranasthalam Mandal, Srikakulam-District 5...

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    06

    TAPI Technology & API Services

    Israel
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    CPhI Japan
    Attending
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    Virtual BoothTAPI, a leading global supplier of APIs, provides over 350 products and customized CDMO solutions for every stage of development.

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    Tikagreller

    Registrant Name : Kyungbo Pharmaceutical Co., Ltd.

    Registration Date : 2021-01-27

    Registration Number : 1673-40-ND

    Manufacturer Name : Teva API India Private Limit...

    Manufacturer Address : Plot No. Q1 to Q4 Industrial Area, Ghirongi Malanpur, Distt.Bhind, India@174 Silok-ro...

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    07

    TAPI Technology & API Services

    Israel
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    CPhI Japan
    Attending
    • fda
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    Virtual BoothTAPI, a leading global supplier of APIs, provides over 350 products and customized CDMO solutions for every stage of development.

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    Tikagreller

    Registrant Name : Samoh Pharmaceutical Co., Ltd.

    Registration Date : 2017-05-18

    Registration Number : 207-33-ND

    Manufacturer Name : Teva API India Ltd.

    Manufacturer Address : Plot No. Q1 -Q4, Industrial Area, Ghirongi, Malanpur Bhind District Madhya Pradesh In...

    TAPI Company Banner

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    08

    HONOUR LAB LTD

    India
    BePharma
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    HONOUR LAB LTD

    India
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    BePharma
    Not Confirmed
    • fda
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Tikagreller

    Registrant Name : Lee Sung International Co., Ltd.

    Registration Date : 2018-03-26

    Registration Number : No. 4579-16-ND(2)

    Manufacturer Name : Honour Lab Limited(Unit-III)

    Manufacturer Address : Plot No.4, Hetero Infrastructure SEZ Ltd., N.Narsapuram Village, Nakkapalli Mandal, A...

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    09

    MSN Laboratories

    India
    BePharma
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    MSN Laboratories

    India
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    BePharma
    Not Confirmed
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Tikagreller

    Registrant Name : Pharmapia Co., Ltd.

    Registration Date : 2018-10-08

    Registration Number : Su258-9-ND

    Manufacturer Name : MSN Organics Private Limited

    Manufacturer Address : Sy. No. 224/A, Bibinagar(Village), Bibinagar(Mandal), Yadadri Bhuvanagiri District, T...

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    10

    MSN Laboratories

    India
    BePharma
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    MSN Laboratories

    India
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    BePharma
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.
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    Tikagreller

    Registrant Name : Korea United Pharmaceutical Co., Ltd.

    Registration Date : 2019-02-21

    Registration Number : No. 258-9-ND(1)

    Manufacturer Name : MSN Organics Private Limited

    Manufacturer Address : Sy. No. 224/A, Bibinagar(Village), Bibinagar(Mandal), Yadadri Bhuvanagiri District, T...

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    01

    Polpharma

    Poland
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    Ce BioForum
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    Virtual BoothPolpharma is a Polish CDMO of APIs and a significant European API producer, delivering products to companies worldwide.

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    Ticagrelor

    About the Company : Polpharma API, part of a leading Polish pharmaceutical group, has over 70 years of experience in process development and cGMP manufacturing. We offer end-to-end solutions, from API...

    Polpharma API, part of a leading Polish pharmaceutical group, has over 70 years of experience in process development and cGMP manufacturing. We offer end-to-end solutions, from API development to scale-up, at our FDA-approved plant in Central Europe. Our expert team provides high-quality, tailor-made services for small molecule API clinical candidates, with strong regulatory support and world-class facilities. Trusted by global partners, we specialize in complex chemical processes and deliver exceptional customer experiences. Polpharma API – Your reliable European CDMO partner.
    Polpharma CB

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    02

    LGM Pharma

    U.S.A
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    Interphex
    Booth #3514
    • fda
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    Virtual BoothLGM Pharma accelerates & optimizes the new product pathway from early development through commercialization.

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    Ticagrelor

    About the Company : LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, ...

    LGM Pharma is a global leader in sourcing hard-to-find APIs and intermediates for the pharmaceutical and biotech industries. LGM is also a full service CDMO providing formulation, analytical method development and testing, and commercial manufacturing. LGM Pharma offers custom API synthesis, analytical development, and regulatory services. With a network of over 300 accredited CGMP manufacturing partners, LGM provides unparalleled supply chain security. And, with over 100,000 square feet of FDA-inspected cGMP manufacturing and warehouse capacity, LGM Pharma provides a one-stop solution for solid dose, powder, semi-solid and liquid drugs.
    LGM Pharma CB

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    03

    Rochem International Inc

    U.S.A
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    CPhI WW Frankfurt
    Booth #12.0F117
    • fda
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    Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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    Ticagrelor

    About the Company : Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quali...

    Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quality ingredients manufactured in China. Headquartered in the Hauppauge, New York, Rochem has 16 offices spread across the globe to cater to the needs of its customers. Rochem’s operations are fully cGMP compliant and has been audited by the USFDA as well as several multinational organizations. It also trains and audits its partners to ensure all of their technologies and systems are FDA-compliant.
    Rochem

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    04

    Cohance Lifesciences

    India
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    BePharma
    Not Confirmed
    • fda
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    Virtual BoothCohance Lifesciences, offers full range of CDMO services for small molecule APIs, intermediates, ADCs, Pellets and Formulations.

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    Ticagrelor

    About the Company : Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our...

    Cohance Lifesciences is a leading CDMO and API platform, offering products and services across all phases of a molecule’s lifecycle from development to commercialzation. With our expertise in complex chemistries, we provide end-to-end CDMO services to global innovators and have delivered numerous projects from concept to commercialization over the years.As a global API player, we serve customers across nearly 60 countries with 80+ molecules backed by robust R&D, regulatory capabilities and manufacturing infrastructure. We are among the top backward integrated exporters of pellets and have strong development and manufacturing capabilities.
    Cohance

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    05

    Dr. Reddy's Laboratories

    India
    arrow
    CPhI Japan
    Booth #5N-12
    • fda
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    Virtual BoothDRL offers a portfolio of products & services, including APIs, CMO services, generics, biosimilars & differentiated formulations.

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    Ticagrelor

    About the Company : Founded in 1984, DRL is well-known for its generic APIs and its track record in drug product development. It is one of the earliest pharma API manufacturers with a diverse portfoli...

    Founded in 1984, DRL is well-known for its generic APIs and its track record in drug product development. It is one of the earliest pharma API manufacturers with a diverse portfolio that provides high-quality, low-cost APIs to leading pharma companies in 80+ countries. It has 8 USFDA-inspected facilities – 6 in India & 1 each in Mexico & the UK & are inspected by international regulatory authorities on a regular basis. Its facilities are supplemented by formulation facilities that provide a wide range of dosage forms. Product(s) under patent(s) are offered only for R&D purposes U/S 107A of the Patent Act and not for commercial sale
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    06

    Jai Radhe Sales

    India
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    BePharma
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    Virtual BoothJai Radhe Sales is your partner for all your sourcing needs.

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    Ticagrelor

    About the Company : Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete ...

    Jai Radhe Sales was founded in 1999 as an out-of-the-box distribution firm specializing in the global supply of high-quality pharmaceutical ingredients. The firm provides complete sourcing solutions for pharmaceutical products from India, including technical and regulatory assistance. It believes in providing its customers with high-quality products at reasonable prices. It has always endeavored to achieve global standards in the field of pharmaceuticals and has carved out a niche for itself through new methods based on current market needs. Today, it has established itself as a truly global company, with exports to almost every continent.
    Jai Radhe Sales

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    07

    Faran Shimi Pharmaceutical

    Iran
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    BePharma
    Not Confirmed
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    Virtual BoothFaran Shimi: Leading producer of high-quality APIs & alkaloid opiates, serving major pharmaceutical companies across the Middle East.

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    Ticagrelor

    About the Company : Faran Shimi Pharmaceutical Company, established in 2001 and affiliated with Golrang Pharmaceutical Investment Co, manufactures high-quality Active Pharmaceutical Ingredients (APIs)...

    Faran Shimi Pharmaceutical Company, established in 2001 and affiliated with Golrang Pharmaceutical Investment Co, manufactures high-quality Active Pharmaceutical Ingredients (APIs) and finished dosage forms. For the past three years, the company focused on extracting alkaloid opiates, controlled substances, and narcotics. The APIs are widely used by major pharmaceutical companies nationwide and exported to the Middle East. All production adheres to local GMP standards in an SOP-driven environment with modern systems and utilities, ensuring the highest quality and safety.
    Faran Shimi Pharmaceutical

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    08

    Aarti Pharmalabs

    India
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    BePharma
    Not Confirmed
    • fda
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    Virtual BoothAarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

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    About the Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, corticosteroids, cyto...

    Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, corticosteroids, cytotoxic & oncology products. It has 2 R&D centers & 3 cGMP plants successfully audited by the USFDA, EUGMP, EDQM, KFDA & COFEPRIS. It offers CDMO services for generic APIs & NCEs, intermediates & key building blocks.Note: None of the products will be supplied to countries in which this could be in conflict with existing patents. Further, any products under patent will be offered for R&D purposes only. However, the final responsibility lies with the buyer
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    09

    Aptra Synthesis

    India
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    BePharma
    Not Confirmed
    • fda
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    Virtual BoothAptra Synthesis produces APIs, Pellets (Semi-finished Formulations), and Intermediates.

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    Ticagrelor

    About the Company : Aptra Synthesis Private Limited, is a reliable and vertically integrated manufacturer of APIs and intermediates, boasting state-of-the-art manufacturing facilities that adhere to G...

    Aptra Synthesis Private Limited, is a reliable and vertically integrated manufacturer of APIs and intermediates, boasting state-of-the-art manufacturing facilities that adhere to GMP standards. We take great pride in producing top-notch intermediates through our fully backward-integrated process. Aptra Synthesis Private Limited (ASPL) stands as one of the rapidly emerging manufacturers of Active Pharmaceutical Ingredients (APIs), Pellets (Semi-finished Formulations), and Intermediates.
    Aptra Synthesis

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    10

    HRV Global Life Sciences

    India
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    CPhI North America
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    Virtual BoothHRV Global Life Sciences - Market Expansion Leader in Pharmaceuticals.

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    Ticagrelor

    About the Company : HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It...

    HRV Global is a leading global manufacturer, seller & exporter of a wide range of APIs, advanced intermediates, pellets, food grade chemicals, food additives & food ingredients. It offers services such as sourcing, manufacturing & supply, helping partners enter new markets worldwide. Its strong partnerships with major players in the pharma and food additive industries help HRV Global effectively promote projects and products. HRV Global represents over 30 large Indian drugmakers, primarily targeting Europe, the US & the Middle East markets. Headquartered in India, HRV Global has offices in the US, Switzerland, Dubai, Lithuania & Turkey.
    HRV Global Life Sciences

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REDDY'S)","address":"564\/A\/22, ROAD NO.92","city":"HYDERABAD,ANDHRA PRADESH","supplier":"MYLAN LABORATORIES LIMITED FDF UNIT-3","supplierCountry":"INDIA","foreign_port":"WALUJ (AURANGABAD)","customer":"VIATRIS","customerCountry":"INDIA","quantity":"59.93","actualQuantity":"59.934","unit":"KGS","unitRateFc":"2501.8","totalValueFC":"151386.1","currency":"USD","unitRateINR":"213154.5","date":"14-Nov-2024","totalValueINR":"12775201.8","totalValueInUsd":"151386.1","indian_port":"Indore-EPZ\/SEZ","hs_no":"29321990","bill_no":"6674477","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"WALUJ (AURANGABAD)","supplierAddress":"Plot No 11,12 & 13, SEZ Phase II, ISEZ, Sector 3, Pithampur,Dist Dhar SDNF India","customerAddress":"564\/A\/22, ROAD NO.92"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1735756200,"product":"TICAGRELOR","address":"8-3-166\/7\/1, HETERO HOUSE,","city":"HYDERABAD, AP.","supplier":"HONOUR LAB LTD","supplierCountry":"INDIA","foreign_port":"HIPL SEZ","customer":"HONOUR LAB LTD","customerCountry":"INDIA","quantity":"13.00","actualQuantity":"13","unit":"KGS","unitRateFc":"977.9","totalValueFC":"12671.5","currency":"USD","unitRateINR":"84050","date":"02-Jan-2025","totalValueINR":"1092650","totalValueInUsd":"12671.5","indian_port":"Vizag-HIPL SEZ","hs_no":"29420090","bill_no":"7569205","productDescription":"Re-Import","marketType":"REGULATED MARKET","country":"INDIA","selfForZScoreResived":"Pharma Grade","supplierPort":"HIPL SEZ","supplierAddress":"HETERO INFRASTRUCTURE SEZ LTD N.NARASAPURAM VILLAGE,NAKKAPALLY MA SDNF India","customerAddress":"8-3-166\/7\/1, HETERO HOUSE,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736533800,"product":"TICAGRELOR(BATCH NO-ETG-705-241206-1) TICAGRELOR(BATCH NO-ETG-705-241206-1)","address":"PLOT NO.5222, PHASE- IV,","city":"AHMEDABAD -","supplier":"NANTONG CHANYOO PHARMATECH","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"UNISON PHARMACEUTICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"68.56","actualQuantity":"68.56","unit":"KGS","unitRateFc":"540","totalValueFC":"37181.6","currency":"USD","unitRateINR":"46764","date":"11-Jan-2025","totalValueINR":"3206139.84","totalValueInUsd":"37181.6","indian_port":"Ahmedabad Air","hs_no":"29335990","bill_no":"7737741","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.2 TONGHAI SI ROAD, YANGKOU CHEMI CAL INDUSTRIAL PARK, RUDONG COASTAL ECONOMIC DEVELOPMENT ZONE,JIANGSU, China","customerAddress":"PLOT NO.5222, PHASE- IV,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1736533800,"product":"TICAGRELOR(BATCH NO-ETG-705-241206-1) TICAGRELOR(BATCH NO-ETG-705-241206-1)","address":"PLOT NO.5222, PHASE- IV,","city":"AHMEDABAD -","supplier":"NANTONG CHANYOO PHARMATECH","supplierCountry":"CHINA","foreign_port":"SHANGHAI","customer":"UNISON PHARMACEUTICALS PRIVATE LIMITED","customerCountry":"INDIA","quantity":"151.44","actualQuantity":"151.44","unit":"KGS","unitRateFc":"540","totalValueFC":"82129.3","currency":"USD","unitRateINR":"46764","date":"11-Jan-2025","totalValueINR":"7081940.16","totalValueInUsd":"82129.3","indian_port":"Ahmedabad Air","hs_no":"29335990","bill_no":"7737741","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI","supplierAddress":"NO.2 TONGHAI SI ROAD, YANGKOU CHEMI CAL INDUSTRIAL PARK, RUDONG COASTAL ECONOMIC DEVELOPMENT ZONE,JIANGSU, China","customerAddress":"PLOT NO.5222, PHASE- IV,"},{"dataSource":"API Import","activeIngredients":"","year":"2025","qtr":"Q1","strtotime":1740162600,"product":"TICAGRELOR (FORM-III) TICAGRELOR (FORM-III)","address":"101, SITARAM MANSION,","city":"KAROL BAGH, NEW DELHI","supplier":"NANTONG CHANYOO PHARMACEUTICAL CO LTD","supplierCountry":"CHINA","foreign_port":"SHANGHAI - PU DONG","customer":"JODAS EXPOIM PVT. LTD","customerCountry":"INDIA","quantity":"1.00","actualQuantity":"1","unit":"KGS","unitRateFc":"1650","totalValueFC":"1664.9","currency":"N\/A","unitRateINR":"144787.5","date":"22-Feb-2025","totalValueINR":"144787.5","totalValueInUsd":"1664.9","indian_port":"Hyderabad Air","hs_no":"29349990","bill_no":"8503089","productDescription":"API","marketType":"REGULATED MARKET","country":"CHINA","selfForZScoreResived":"Pharma Grade","supplierPort":"SHANGHAI - PU DONG","supplierAddress":"NO.2 TONGHAI SI ROAD YANGKOU CHEMIC AL INDUSTRIAL PARK SDNF China","customerAddress":"101, SITARAM MANSION,"}]
    02-Jan-2021
    28-Feb-2025
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    API Imports and Exports

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    INTERMEDIATE SUPPLIERS

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    01

    Aarti Pharmalabs

    India
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    Not Confirmed
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    Virtual BoothAarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

    2-((3aR,4S,6R,6aS)-6-amino-2,2-dimethyltetrahydro-...

    CAS Number : 376608-65-0

    End Use API : Ticagrelor

    About The Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, c...

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    02

    Aarti Pharmalabs

    India
    BePharma
    Not Confirmed
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    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothAarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

    4,6-dichloro-2-(propyl sulfanyl) pyrimidin-5-amine

    CAS Number : 145783-15-9

    End Use API : Ticagrelor

    About The Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, c...

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    03

    Aarti Pharmalabs

    India
    BePharma
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    Virtual BoothAarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

    (1R,2S)-2-(3,4-difuorophenyl)cyclopropan-1- amine ...

    CAS Number : 376608-71-8

    End Use API : Ticagrelor

    About The Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, c...

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    04

    Aarti Pharmalabs

    India
    BePharma
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP

    Virtual BoothAarti Pharmalabs is a partner of choice for APIs & Intermediates and the largest Indian manufacturer of Xanthine Derivatives.

    (1R, 2S)-2- (3,4-difuorophenyl) cyclopropanamine, ...

    CAS Number : 1402222-66-5

    End Use API : Ticagrelor

    About The Company : Aarti Pharmalab, earlier the pharma division of Aarti Industries, is a leading Indian manufacturer of APIs. It has dedicated facilities to manufacture HPAPIs, c...

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    Corporate PDF

    05

    Amara Labs

    India
    BePharma
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    Amara Labs

    India
    BePharma
    Not Confirmed
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    • EDQM
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    4,6-DICHLORO-2-PROPYLTHIOPYRIMIDINE-5-AMINE

    CAS Number : 145783-15-9

    End Use API : Ticagrelor

    About The Company : Amara Labs Pvt Ltd is a WHO-GMP certified manufacturing company wholly owned by a team of technocrats with working experience of more than 20 years in Multi-Nat...

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    06

    Anhui HaiKang Pharmaceutical Co. Lt...

    China
    BePharma
    Not Confirmed
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    Anhui HaiKang Pharmaceutical Co. Lt...

    China
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    2-[[(3aR,4S,6R,6aS)-6-Aminotetrahydro-2,2-dimethyl...

    CAS Number : 376608-65-0

    End Use API : Ticagrelor

    About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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    07

    Anhui HaiKang Pharmaceutical Co. Lt...

    China
    BePharma
    Not Confirmed
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    Anhui HaiKang Pharmaceutical Co. Lt...

    China
    BePharma
    Not Confirmed
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    (1R,2S)-2-(3,4-Difluorophenyl)

    CAS Number : 376608-71-8

    End Use API : Ticagrelor

    About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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    08

    Anhui HaiKang Pharmaceutical Co. Lt...

    China
    BePharma
    Not Confirmed
    arrow

    Anhui HaiKang Pharmaceutical Co. Lt...

    China
    BePharma
    Not Confirmed
    arrow
    • fda
    • EDQM
    • WHO-GMP
    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    4,6-Dichloro-2-(propylthio)pyrimidin-5-amine

    CAS Number : 145783-15-9

    End Use API : Ticagrelor

    About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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    Portfolio PDF

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    Virtual Booth

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    09

    Anhui HaiKang Pharmaceutical Co. Lt...

    China
    BePharma
    Not Confirmed
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    Anhui HaiKang Pharmaceutical Co. Lt...

    China
    BePharma
    Not Confirmed
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    • fda
    • EDQM
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    Virtual Booth Boost your online visibility by uploading your products, APIs, FDFs, intermediates, excipients, and services for free on PharmaCompass. Rank higher among suppliers and expand your reach across the internet efficiently and cost-effectively.

    N-Propylsulfuric diamide-sodium

    CAS Number : 1642873-03-7

    End Use API : Ticagrelor

    About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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    10

    Anhui HaiKang Pharmaceutical Co. Lt...

    China
    BePharma
    Not Confirmed
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    Anhui HaiKang Pharmaceutical Co. Lt...

    China
    BePharma
    Not Confirmed
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    • EDQM
    • WHO-GMP
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    5-(4-bromophenyl)-4,6-dichloropyrimidine

    CAS Number : 146533-41-7

    End Use API : Ticagrelor

    About The Company : Anhui Haikang Pharmaceutical Co., Ltd. was established in 2009 and located in a High-tech industry park, Anqing City, Anhui Province---a famous historical and c...

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    Only 10 entries up to this point, click to access all click full view read-more
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    DRUG PRODUCT COMPOSITIONS

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    DOSAGE - TABLET;ORAL - 60MG

    USFDA APPLICATION NUMBER - 22433

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    DOSAGE - TABLET;ORAL - 90MG

    USFDA APPLICATION NUMBER - 22433

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    ABOUT THIS PAGE

    Looking for 274693-27-5 / Ticagrelor API manufacturers, exporters & distributors?

    Ticagrelor manufacturers, exporters & distributors 1

    83

    PharmaCompass offers a list of Ticagrelor API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Ticagrelor manufacturer or Ticagrelor supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Ticagrelor manufacturer or Ticagrelor supplier.

    PharmaCompass also assists you with knowing the Ticagrelor API Price utilized in the formulation of products. Ticagrelor API Price is not always fixed or binding as the Ticagrelor Price is obtained through a variety of data sources. The Ticagrelor Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Ticagrelor

    Synonyms

    274693-27-5, Brilinta, Brilique, Azd6140, Azd-6140, Possia

    Cas Number

    274693-27-5

    Unique Ingredient Identifier (UNII)

    GLH0314RVC

    About Ticagrelor

    An adenosine triphosphate analogue and reversible P2Y12 PURINORECEPTOR antagonist that inhibits ADP-mediated PLATELET AGGREGATION. It is used for the prevention of THROMBOEMBOLISM by patients with ACUTE CORONARY SYNDROME or a history of MYOCARDIAL INFARCTION.

    Ticagrelor Manufacturers

    A Ticagrelor manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Ticagrelor, including repackagers and relabelers. The FDA regulates Ticagrelor manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Ticagrelor API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Ticagrelor manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Ticagrelor Suppliers

    A Ticagrelor supplier is an individual or a company that provides Ticagrelor active pharmaceutical ingredient (API) or Ticagrelor finished formulations upon request. The Ticagrelor suppliers may include Ticagrelor API manufacturers, exporters, distributors and traders.

    click here to find a list of Ticagrelor suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Ticagrelor USDMF

    A Ticagrelor DMF (Drug Master File) is a document detailing the whole manufacturing process of Ticagrelor active pharmaceutical ingredient (API) in detail. Different forms of Ticagrelor DMFs exist exist since differing nations have different regulations, such as Ticagrelor USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Ticagrelor DMF submitted to regulatory agencies in the US is known as a USDMF. Ticagrelor USDMF includes data on Ticagrelor's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Ticagrelor USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Ticagrelor suppliers with USDMF on PharmaCompass.

    Ticagrelor KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Ticagrelor Drug Master File in Korea (Ticagrelor KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Ticagrelor. The MFDS reviews the Ticagrelor KDMF as part of the drug registration process and uses the information provided in the Ticagrelor KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Ticagrelor KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Ticagrelor API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Ticagrelor suppliers with KDMF on PharmaCompass.

    Ticagrelor CEP

    A Ticagrelor CEP of the European Pharmacopoeia monograph is often referred to as a Ticagrelor Certificate of Suitability (COS). The purpose of a Ticagrelor CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Ticagrelor EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Ticagrelor to their clients by showing that a Ticagrelor CEP has been issued for it. The manufacturer submits a Ticagrelor CEP (COS) as part of the market authorization procedure, and it takes on the role of a Ticagrelor CEP holder for the record. Additionally, the data presented in the Ticagrelor CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Ticagrelor DMF.

    A Ticagrelor CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Ticagrelor CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Ticagrelor suppliers with CEP (COS) on PharmaCompass.

    Ticagrelor WC

    A Ticagrelor written confirmation (Ticagrelor WC) is an official document issued by a regulatory agency to a Ticagrelor manufacturer, verifying that the manufacturing facility of a Ticagrelor active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Ticagrelor APIs or Ticagrelor finished pharmaceutical products to another nation, regulatory agencies frequently require a Ticagrelor WC (written confirmation) as part of the regulatory process.

    click here to find a list of Ticagrelor suppliers with Written Confirmation (WC) on PharmaCompass.

    Ticagrelor NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Ticagrelor as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Ticagrelor API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Ticagrelor as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Ticagrelor and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Ticagrelor NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Ticagrelor suppliers with NDC on PharmaCompass.

    Ticagrelor GMP

    Ticagrelor Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Ticagrelor GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Ticagrelor GMP manufacturer or Ticagrelor GMP API supplier for your needs.

    Ticagrelor CoA

    A Ticagrelor CoA (Certificate of Analysis) is a formal document that attests to Ticagrelor's compliance with Ticagrelor specifications and serves as a tool for batch-level quality control.

    Ticagrelor CoA mostly includes findings from lab analyses of a specific batch. For each Ticagrelor CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Ticagrelor may be tested according to a variety of international standards, such as European Pharmacopoeia (Ticagrelor EP), Ticagrelor JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Ticagrelor USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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