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    Overview of cream, lotion, ointment, gel & hormonal products for topical drug delivery offered by leading pharma contract manufacturers (CMOs).

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    Overview of cream, lotion, ointment, gel & hormonal products for topical drug delivery offered by leading pharma contract manufacturers (CMOs).

    Q1. What is topical drug administration and what are the different types of topical dosage forms?

    Topical drug administration refers to the application of topical dosage forms to the surface of the skin or mucous membrane of the eye, ear, nose, mouth, vagina, etc. with the intent of containing the pharmacological effect of the drug only to the surface or within layers of the skin or mucous membrane. 

    Drug delivery of topical formulations via the skin is becoming progressively popular due to its convenience and affordability. The skin is the most important mechanical barrier to the penetration of many drug substances and acts as an ideal site to deliver drugs, both locally and systemically. 

    The topical route of drug administration is used for the local treatment of skin, control of external and internal parasites, and transdermal delivery of therapeutic agents. Furthermore, topical formulations are made up in a vehicle, or base, which may be optimised for a particular site of the body or type of skin condition being treated. 

    Topical dosage forms include ointments, lotions, gels, pastes, and creams, among various other formulations. The rate of drug release from ointments, creams, lotions, gels, and pastes is principally determined by the semisolid base used in the formulation.

     

    Some Common Topical Formulations

    - Ointments

    Ointments are semi-solid, water-free or nearly water-free (80% oil) preparations in which a drug is suspended or dissolved in a grease or oil base. They are thus greasy, sticky, emollient, protective, and occlusive, due to which application to hairy areas should be avoided.

    Ointments may include a hydrocarbon (paraffin), wool fat, beeswax, macrogols, emulsifying wax, cetrimide or vegetable oil (olive oil, arachis oil, coconut oil). Other substances which may be used as a base include petroleum, liquid petroleum (mineral oil), olive oil, lanolin, and other animal fats.


    - Creams

    Creams are an intermediate preparation between wet dressings that dry skin lesions and ointments that keep lesions moist. Creams are semisolid, have a high percentage of water, are water-washable and don't leave a greasy residue after use as compared to ointments.

    Additionally, creams absorb fluids from the skin and spread so easily that any medication dissolved in the cream comes in good contact with the skin. Cream formulations require preservatives to extend its shelf life.


    - Gels

    Gels are semisolid dosage forms that contain a gelling agent (often cellulose) to provide stiffness to a liquid solution or colloidal dispersion for external application to the skin. Gels are transparent preparations which liquify on contact with the skin, dry, and leave a thin film of active medication. Gels also often include preservatives and fragrances.


    - Lotions 

    Lotions are liquids, usually aqueous or sometimes alcoholic preparations, containing insoluble material in the form of a suspension or emulsion, intended for external application without rubbing for skin conditions such as itching, infection, allergy, pain, etc.

     

    Some Advantages of Topical Drug Administration

    - Useful for local delivery of agents, particularly those which have toxic effects if administered systemically.

    - Avoidance of first pass metabolism.

    - Selective drug delivery to specific sites, convenient to use and easy to apply, suitable for self-medication, better patient compliance, and easy termination.

    - Gastro-intestinal incompatibility avoidance.

    - Avoidance of the risks and inconveniences of administration and the varied conditions of absorption, like pH changes, presence of enzymes, gastric emptying time, etc. in enteral or parenteral routes.

    - Provides effectiveness in low doses and by continuous drug input, avoids fluctuation in drug levels and risks.

    - Improved physiological and pharmacological response.

    - Larger area of application compared to other routes. 

    Q2. What are hormonal gels and creams?

    A hormone is defined as a chemical released by a cell or a gland in one part of the body that sends out messages that affect cells in other parts of the organism. Only a small amount of hormone is required to alter cell metabolism. 

    Hormones regulate growth, sex drive, sexual development, reproduction, sexual function, metabolism, and thirst among other things. Additionally, hormones are integral to our digestive, immune, urinary, reproductive, nervous, cardiovascular, respiratory and skeletal systems.

    Hormonal formulations are drug products with a mixture of active ingredients (APIs), specifically hormones, along with other inactive components that elicit a therapeutic response upon administration. For example, hormone therapy, used to treat cancers, are used to block hormones or their actions. 

    There are numerous hormonal formulations including hormonal tablets, capsules, liquids and injectables. Hormonal preparations such as hormonal gel and solutions and hormonal creams are also available in the market. 

     

    Hormonal Products - Hormonal Gels & Hormonal Creams

    Hormonal Products - Gels 

    A gel is a solid or semisolid system of at least two constituents, consisting of a condensed mass enclosing and interpenetrated by a liquid. Topical gel formulations provide a suitable delivery system for drugs because they are not very greasy and can be easily removed from the skin.

    Hormonal gels are semi-solid drug delivery systems in which the active ingredient or mixture of active ingredients are composed of hormones. These are the agents that elicit a therapeutic response for the medical indication being treated. Some examples of hormonal preparations in gel form include estradiol gel, testosterone gel, oestrogen gel, etc.

    Hormonal Products - Creams

    Creams are viscous semi-solid emulsions for external use. A cream may be a water-in-oil or oil-in-water emulsion, depending on the emulsifying agent used. They are intended to be applied to the skin or certain mucous membranes for protective, therapeutic, or prophylactic purposes.

    Hormonal creams are semi-solid drug delivery formulations or semi solid drug delivery systems in which the active ingredient or mixture of active ingredients are composed of hormones. These hormonal preparations are the agents that elicit a therapeutic response upon administration. Some examples of hormonal preparations in cream form include estrogen cream, progesterone cream, etc.

     

    Various Contract Manufacturing Organizations (CMOs), CDMOs, etc. offer services for contract manufacturing hormonal cream formulations and contract manufacturing hormonal gel and solutions. 

    By outsourcing services for contract manufacturing hormonal gels and contract manufacturing hormonal cream products, one can ensure that clinical and commercial cGMP manufacturing goals are met. 

    Outsourcing services for contract manufacturing hormonal gel and contract manufacturing hormonal cream products can be beneficial as the manufacture of these hormonal semisolid dosage forms is very complex. Furthermore contract manufacturing hormonal cream and contract manufacturing hormonal gel formulations can reduce costs and time to market. 

    Q3. What are the quality factors influencing commercial manufacturing of semi-solid dosage forms?

    Semi-solid dosage form manufacturing and semi-solid dosage form development requires specialized production techniques to assure high-quality results. Some of the quality factors influencing GMP bulk manufacturing of semisolid dosage forms are noted in detail below.

     

    Some Physical Properties Affecting Quality

    - Homogeneity

    Homogeneity is the state of being all of the same kind. Homogeneity is important, because semisolids involve more than one phase, and all phases must be properly blended to achieve the desired result. The API as well as all excipients and other ingredients, must be uniformly distributed throughout the mixture. Proper homogeneity produces even distribution of medication in ointments, gels and creams.


    - Particle Size Distribution (PSD)

    Particle size also plays a key role in topical semi-solid drug delivery as it determines the product’s pharmacologic properties. For instance, if the API is suspended in a vehicle such as a cream or gel, the particle size will interact with the vehicle’s solubility to dictate the dissolution rate. Particle Size Distribution (PSD) also impacts the depth, rate, and pathway of absorption through the skin. 


    - Spreadability

    Semisolid drugs must also exhibit appropriate spreadability to ensure that the desired therapeutic effect is achieved, because spreadability determines the distribution of the API over the area to which the semisolid is applied. Poor spreadability can lead to patient dissatisfaction.


    - Surfactants

    Surfactants are the most common inactive ingredients used in topical drug products. Surfactants in topical products play many functional roles such as emulsifiers, permeation enhancers, and solubilizers. Proper surfactant use enables the formation of emulsions and suspensions of oil and aqueous phases and is crucial to achieving stable formulations.

     

    Other Factors Affecting Quality

    - Equipment

    Proper equipment is equally important as correct formulation in the manufacture of quality semi-solid pharmaceutical dosage forms. Mixers, emulsifiers, jackets, tanks, agitators, mills and other equipment are integral to the GMP bulk manufacturing process and must function at high efficiency for desired results.


    - Testing

    Monitoring the quality of drug products requires physical, microbiological and chemical testing throughout dosage form development and GMP bulk manufacturing of semi-solids. Specific testing of semi-solid formulations maintains quality control and prevents unfavorable results.


    - Packaging and Storage

    Maintaining proper packaging and storage conditions is crucial for the production of quality semi-solid products. Storage of semisolids should be at temperatures not exceeding 25° unless otherwise authorized as temperature variations can result in the degradation of gels, creams, ointments, etc. 

    They should also not be allowed to freeze and must be stored in a well-closed container or, if the preparation contains water or other volatile ingredients, they should be stored in an air-tight container.

    Q4. Which are the leading pharmaceutical companies offering contract services for semi-solid dosage forms?

    Various Contract Manufacturing Organizations (CMOs) and CDMOs offer contract development and pharmaceutical contract manufacturing services for semi-solid drug products.

    This includes contract manufacturing for topical semi-solids such as creams (e.g. contract manufacturing hormonal cream), gels (e.g. contract manufacturing hormonal gel), lotions, liquid solutions, ointments, and pastes, along with other novel drug delivery systems. 

    Leading Contract Manufacturing Organizations (CMOs), CDMOs offering contract manufacturing for topical semi-solid pharmaceutical dosage forms are noted below.

     

    Fermion Oy - Semi-solid Manufacturing of Cream and Ointments

    Fermion, through its mother company Orion, is an experienced manufacturer of several dosage forms that offers contract manufacturing for topical semi-solid pharmaceutical drug products. They manufacture creams, ointments, liquids, hormonal gels and solutions, tablets, capsules, dry powder inhalers, etc. for global markets.

    Mission Pharmacal - Semi Solid Dosage Form Manufacturing 

    Mission Pharmacal manufactures a variety of pharmaceutical products and offers leading-edge capabilities and technologies. Using the latest high-capacity equipment it manufactures and specializes in creams, gels, liquids and tablets.

    Polpharma - Topical Pharmaceutical Contract Manufacturing Services 

    Polpharma offers contract services including pharmaceutical contract manufacturing services for various topical and semisolid dosage forms such as gels, emulsions and ointments. It offers clinical and commercial cGMP manufacturing for semi solid dosage forms.

    Recipharm AB - Semi-solid Formulation Development & Contract Manufacturing for Topical Semi-Solid Pharmaceutical Dosage Forms

    Recipharm is equipped to take on semi-solid formulation development and semi-solid manufacturing (clinical and commercial cGMP manufacturing) projects. General APIs, as well as corticosteroids and controlled drugs, are handled within Recipharm's semi-solid dose manufacturing facilities for the commercial manufacturing of semisolid dosage forms.

    JGL d.d - Pharmaceutical Contract Manufacturing and Packaging for Semi-solids

    JGL manufactures various semi-solid dosage forms such as ointments, creams and gels along with liquid solutions, in the form of an aluminium or plastic tube. The filling process and packing is done by simply switching between different formats.

    It offers clinical and commercial cGMP manufacturing for semi solid dosage forms. JGL also offers various solids and liquids in addition to semi-solid dosage forms.

    Eurofins CDMO - Semi-solids

    Eurofins CDMO offers drug formulation development contract services encompassing preclinical contract development, formulation screening and dosage form development, and analytical contract development of semi solid dosage forms for skin, mucosal or oral delivery.

    Madras Pharmaceuticals - Contract Manufacturing for Topical Semi-Solid Pharmaceutical Drug Products

    Madras Pharmaceuticals offers various topical dosage forms such as cream, ointment, gel along with other solid and liquid dosage forms like tablets, capsules, dry powder for suspensions, syrups, etc. It offers commercial manufacturing of semisolid dosage forms.

    Grunenthal - Cream / Lotion / Ointment Pharmaceutical Contract Manufacturing and Packaging

    Grunenthal's Tecnandina S.A. offers pharmaceutical contract manufacturing and packaging services. It is the largest and most modern manufacturing plant that can offer commercial manufacturing of semi solid dosage forms.

    It offers a variety of formulations such as granules, coated tablets, capsules, liquids, semi solid dosage forms and packaging in various blister, sachet or bottle forms.

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            OINTMENT & CREAMS (TUBES)

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            Gracure's facility has the capability to manufacture tables, hard gelatin capsules, oral liquids, dry powder syrups, and ointments. The facility is designed for serving international markets.

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            WellSpring Consumer Healthcare

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            TOPICAL CONTRACT MANUFACTURING & PACKAGING

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            WellSpring specializes in the pharmaceutical contract manufacturing and packaging of tablets, capsules, creams, lotions, ointments and gels as well as non-sterile liquids and suspensions.

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            Appco Pharmaceutical Corp

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            TOPICAL FORMULATIONS

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            A diverse team of experienced scientific professionals, we can be a partner of choice for diverse drug products, including various dosage forms.

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            Sofarimex

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              OINTMENT & CREAM MANUFACTURING

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              Sofarimex is the leading contract manufacturing company for pharmaceutical products in Portugal. Its factory has a large productive flexibility, producing several pharmaceutical dosage forms like solids, liquids, semi-solids & sterile products.

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              Lecifarma

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                FORMULATION DEVELOPMENT & MANUFACTURING

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                Lecifarma is a GMP certified laboratory that works for third parties. We are dedicated to formulation development, manufacture, packaging and quality control of medicines, food supplements, cosmetics and personal care products.

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                Farbe Firma

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                TOPICAL SEMI-SOLID DOSAGE FORMS

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                Farbe Firma will supply several products in a variety of dosage forms like solids, semi solids, steriles (liquids & freeze dried), beta-lactams, hormones, dry powder metered dose inhalers, oral liquids & granulates, from its facilities in the near future.

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                Bioplus Life Sciences

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                CONTRACT MANUFACTURING FOR CREAMS

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                BioPlus Life Sciences offers contract manufacturing services for topical dosage forms, including creams and gels in jars and tube packing.

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                Saneca Pharmaceuticals

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                TOPICAL GEL

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                Saneca Pharma manufactures a variety of liquid, semi-solid and solid dosage forms based on over 70 API’s, with its solid dosage form contract manufacturing facilities producing four billion tablets every year.

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                Delpharm Group

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                TOPICAL FORMULATION MANUFACTURING

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                Delpharm proposes its knowledge and experience to manufacture licensed products, generics, OTC products, dietary supplements, veterinary products, medical devices & highly active and injectable products.

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                Bliss Gvs Pharma Ltd

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                  TOPICAL DOSAGES - GMP CONTRACT MANUFACTURING

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                  Bliss GVS is a fast-growing pharmaceutical company with a proven track record of developing & contract manufacturing oral syrups. Their facility is WHO-GMP approved and can manufacture 7.5 million tubes/ annum at one of its units of production.

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                  S.C. Rompharm Company SRL

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                    EXTERNAL LIQUID SOLUTIONS

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                    Manufacturing in compliance with Romanian law no 95/2006 regarding medicines for human use. Valid Manufacturing Authorization, in full compliance with GMP issued by the National Medicine and Medical Devices Agency.

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                    JGL d.d

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                    MANUFACTURING CAPABILITIES FOR OINTMENTS

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                    JGL manufactures various semi-solid dosage forms such as ointments, creams and gels, in the form of an aluminium or plastic tube. The filling process & packing is done by simply switching between different formats.

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                    Madras Pharmaceuticals

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                    CONTRACT MANUFACTURING OF CREAMS & OINTMENTS

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                    Madras Pharma offers various topical dosage forms such as cream, ointment, gel along with other solid and liquid dosage forms like tablets, capsules, dry powder for suspensions, syrups, etc.

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                    JGL d.d

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                    MANUFACTURING CAPABILITIES FOR CREAMS

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                    JGL offers manufacturing for various solid, liquid and semi-solid dosage forms such as ointments, creams and gels, in the form of an aluminium or plastic tube.

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                    JGL d.d

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                    MANUFACTURING CAPABILITIES FOR LOTIONS

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                    JGL manufactures semi-solid dosage forms such as ointment, cream, gel, soap and lotion in a completely automated and monitored process.

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                    Pierre Fabre

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                    CDMO FOR CREAM, OINTMENT & GEL

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                    Pierre Fabre CDMO offers complete pharmaceutical drug product development to commercial manufacturing for paste dosage forms such as creams, ointments, gels and conventional dry forms including tablets, capsules and powder sachets.

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                    Axxelent Pharma Science

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                      CDMO FOR SEMI-SOLID FORMULATIONS

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                      Axxelent is capable of manufacturing ointments, creams and gels. Its batch size ranges from 100 kgs to 500 kgs and its filling line can handle Alu & Lami tubes from 10 gm to 200gm.

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                      Prague Scientific

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                      CONTRACT MANUFACTURING FOR SEMI-SOLIDS

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                      Prague Scientific offers contract manufacturing of semi-solid dosage forms, including topical gels, creams and ointments (sterile and non-sterile).

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                      Priyans Drugs

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                        OINTMENT

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                        Priyans Drugs headquartered in Singapore, is a professionally managed company supporting the pharmaceuticals business globally.

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                        Priyans Drugs

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                          OIL-IN-WATER (O/W) CREAM

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                          Priyans Drugs headquartered in Singapore, is a professionally managed company supporting the pharmaceuticals business globally.

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                          Priyans Drugs

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                            WATER-IN-OIL (W/O) CREAM

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                            Priyans Drugs headquartered in Singapore, is a professionally managed company supporting the pharmaceuticals business globally.

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                            Eurofins CDMO

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                            SEMI-SOLIDS

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                            Eurofins CDMO offers drug development contract services encompassing preclinical development, formulation screening and development, analytical development of semi-solid dosage forms for skin, mucosal or oral delivery.

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                            Recipharm AB

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                            MANUFACTURING OF SEMI-SOLID DOSAGE FORMS

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                            Recipharm is equipped to take on your semi-solid contract development and manufacturing project. General APIs, as well as corticosteroids and controlled drugs, are handled within Recipharm's semi-solid dose contract manufacturing facilities.

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                            Priyans Drugs

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                              LOTION

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                              Priyans Drugs headquartered in Singapore, is a professionally managed company supporting the pharmaceuticals business globally.

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                              Piramal Pharma Solutions

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                              CDMO FOR CREAMS & OINTMENTS

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                              Apart from OSDs, Piramal also provides liquids, creams and ointments. It offers development, manufacturing & packaging services for liquids, creams and ointments with maximum capacities of 350 batches, 150 batches and 100 batches, respectively.

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                              Pontika Aerotech

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                                TOPICAL FORMULATION CONTRACT MANUFACTURING

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                                Pontika Aerotech is a leading contract research and manufacturing organization offering a variety of drug products, including cream, ointment, and lotion. Its flexible production facilities can handle a wide range of batch sizes for topical formulations.

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                                June Jacobs Labs

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                                  CONTRACT MANUFACTURER FOR CREAMS

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                                  June Jacobs Labs is a full-service turnkey contract manufacturer of cream formulations. It offers various cosmetics, personal care, skincare, pharmaceutical, and oral care drug products with small and large flexible production capacities.

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                                  Tatchempharmpreparaty

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                                    STERILE & NON-STERILE OINTMENT MANUFACTURING

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                                    Tatchempharmpreparaty is a contract manufacturer of sterile and non-sterile ointment formulations. It has capacities to produce more than 25 million skin and eye ointments annually.

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                                    Sterling Pharma

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                                      CONTRACT MANUFACTURING FOR CREAMS & OINTMENTS

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                                      Sterling Pharma has a state-of-the-art contract manufacturing facility for creams and ointments. Its production facility offers the synthesis and testing of semi-solids in batch sizes ranging from 10g to 50kg.

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                                      AVIZ Laboratories

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                                        OINTMENT, LIP BALM & CHEST RUB MANUFACTURING

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                                        Our hot-fill PJ-based ointment line is perfect for the production of cosmetic & medical based ointments, lip balms and chest rubs. Together with our raw material suppliers we are perfectly positioned to assist in bringing your ointment products to stores.

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                                        Pharma Service: Drug Product Manufacturing

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                                        Rafarm S.A

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                                        CREAM

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                                        RAFARM with great manufacturing capabilities and fully equipped production units represents the perfect partner for more than 70 domestic pharmaceutical companies as well as for most of our clients in Europe and the rest of the world.

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                                        Panacea Biotec Limited

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                                        INORGANIC SOL-GEL TOPICAL DELIVERY SYSTEMS

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                                        Panacea’s state-of-the-art pharmaceuticals formulations manufacturing facility at Baddi is built in compliance with cGMP standards and has been audited and certified by USFDA, German Regulatory Authority, TGA Australia and ANVISA Brazil.

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                                        Specpharm

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                                          CREAM / LOTION / OINTMENT MANUFACTURING

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                                          We pride ourselves on the delivery of high quality products & all our partners are audited & meet the high international GMP standards. Our technology includes the manufacture of tablets, syrups, suspensions, creams, gels, ointments, powders & granules.

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                                          AVIZ Laboratories

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                                            CREAM MANUFACTURING

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                                            We also have class leading technology for the production of ointments, soaps and creams.

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                                            Grunenthal

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                                            CREAM / LOTION / OINTMENT MANUFACTURING

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                                            Grunenthal's Tecnandina S.A., its largest & most modern contract manufacturing plant can manufacture a variety of dosage forms such as granules, coated tablets, capsules, liquids, semi-solids & offers packaging in various blister, sachet or bottle forms.

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                                            Pharma Service: Drug Product Manufacturing

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                                            Noveayr Therapeutics

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                                              DEVELOPMENT & MANUFACTURING OF CREAMS

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                                              Pharmaserve NW has the expertise to develop a range of dosage forms such as cream, metered dose inhalers (MDIs), dry powder inhalers (DPIs), nasal sprays and small volume liquids with both laboratory scale and pilot scale facilities.

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                                              COC Farmaceutici

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                                                CONTRACT MANUFACTURING FOR CREAM & GEL

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                                                COC Farmaceutici, specialised in contract manufacturing, filling & packaging of medicines, medical & diagnostic devices, cosmetics & veterinary products in cream & gel, liquid with the advanced filling technologies in sterile & non-sterile environments.

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                                                Humanis

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                                                MANUFACTURING OF CREAMS AND OINTMENTS

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                                                Pharmactive provides contract manufacturing for semi solids including cream, ointment and gel together along with liquid and solid dosage forms such as tablets and capsules.

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                                                DPT Laboratories, Ltd

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                                                CREAM / LOTION / OINTMENT MANUFACTURING

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                                                DPT provides comprehensive pharmaceutical research and development services focused on semi-solid and liquid dosage forms.

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                                                Jubilant HollisterStier

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                                                STERILE OINTMENT FILLING LINE

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                                                Jubilant HollisterStier’s Montreal facility offers one Nordentm ointment filling unit in its sterile filling area. Manufacturing is performed in a pressurized vessel also located in the aseptic core.

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                                                Legacy Pharmaceuticals Switzerland

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                                                  CREAMS

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                                                  Alongside core expertise in parenteral products, Legacy Pharmaceutical also manufactures non-sterile drugs as liquids, tablets, semi-solid formulations and common formulations (creams, salves, pastes and gels) & fill aluminum tubes.

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                                                  Bluepharma

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                                                  SEMI-SOLIDS CLINICAL BATCHES MANUFACTURING

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                                                  Following the strong connection to the academic and innovative research, we are also certified for the manufacturing and packaging of Human Investigational Medicinal Products.

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                                                  Cyndea Pharma S.L

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                                                    OINTMENT / CREAM / GEL CLINICAL TRIAL BATCHES

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                                                    Cyndea Pharma focuses its efforts on the development and manufacturing of generic drugs with a distinctive complexity, either due to their difficulty to develop pharmaceutically, or due to their handling incompatibility with high activity products.

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                                                    Jubilant HollisterStier

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                                                    NON-STERILE OINTMENTS, CREAMS & LIQUIDS IN JAR, TUBES

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                                                    Jubilant HollisterStier offers non-sterile manufacturing services for ointment, cream and liquid products in bottles, tubes, jars, suppositories and applicators.

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                                                    Atral

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                                                      CONTRACT MANUFACTURING OF CREAMS & OINTMENTS

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                                                      Atral's general unit provides contract manufacturing for various pharmaceutical dosage forms such as creams & ointments, tablets, capsules, suppositories, ovules, hard gelatin capsules, oral solutions, powder in sachets for oral solutions, etc.

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                                                      UPM Pharmaceuticals

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                                                      SEMI-SOLID BULK MANUFACTURING & PACKAGING

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                                                      UPM's manufacturing facility encompasses 475,000 square feet on almost seven acres. This facility provides UPM with large scale commercial capabilities for bulk manufacturing & packaging solid oral tablets & capsules, as well as semi-solid manufacturing.

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                                                      Vici Health Sciences

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                                                        CLINICAL SUPPLY OF TOPICAL FORMULATIONS

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                                                        Vici offers cGMP manufacturing for phase I and II clinical trial materials for topical drug products. Its topical range includes creams, ointments, gels, lotions, solutions, and complex emulsions.

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                                                        Softigel Procaps

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                                                        CREAM MANUFACTURING

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                                                        Softigel is specialized in Softgel technologies and offer access to other delivery systems such as sterile liquids, injectables, prefilled syringes, creams, ointments, gels, powders, tablets and hard gel capsules.

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                                                        Softigel Procaps

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                                                        OINTMENT MANUFACTURING

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                                                        Softigel is specialized in Softgel technologies and offer access to other delivery systems such as sterile liquids, injectables, prefilled syringes, creams, ointments, gels, powders, tablets and hard gel capsules.

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                                                        CARBOGEN AMCIS AG

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                                                        GMP COMPLIANT PRODUCTION OF SEMI SOLID FORMS

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                                                        Since 2000, Carbogen Amcis SAS has manufactured over 300 GMP batches of APIs, such as highly potents, cytotoxics, proteins, mAbs, peptides, enzyme inhibitors and antibiotics (non-ß-lactam) and vaccines (non-life).

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                                                        Softigel Procaps

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                                                        GEL MANUFACTURING

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                                                        Softigel is specialized in Softgel technologies and offer access to other delivery systems such as sterile liquids, injectables, prefilled syringes, creams, ointments, gels, powders, tablets and hard gel capsules.

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                                                        Basic Pharma

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                                                          OINTMENTS MANUFACTURING

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                                                          Basic Pharma Manufacturing can be your preferred contract manufacturer for your pharmaceutical or biotech products, both investigational medicinal products (IMPs) and commercial products.

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                                                          Basic Pharma

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                                                            CREAMS MANUFACTURING

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                                                            Basic Pharma Manufacturing can be your preferred contract manufacturer for your pharmaceutical or biotech products, both investigational medicinal products (IMPs) and commercial products.

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                                                            Aesica Pharmaceuticals Limited

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                                                            SEMI-SOLID CLINICAL SUPPLY

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                                                            Aesica development centre is a purpose built facility which will specifically focus on formulation development and clinical manufacture. The development centre will also encompass all supporting analytical services and stability testing capability.

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                                                            Cambrex Corporation

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                                                            CREAM & OINTMENT PRODUCTS

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                                                            Our drug product capabilities cover a wide variety of manufacturing & packaging technologies and we can support many dosage forms. We specialize in solid dosage forms, liquid, gel, cream and ointment products, sterile gel, and finished goods packaging.

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