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    Overview of intermediates & fine chemicals & more on CDMOs for the development & manufacturing of these products, from clinical to commercial scale.

    Egis Contract Manufacturing for Intermediates
    Polpharma is a Polish CDMO of APIs and a significant European API producer, delivering products to companies worldwide.
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    Overview of intermediates & fine chemicals & more on CDMOs for the development & manufacturing of these products, from clinical to commercial scale.

    Q1. What are pharmaceutical intermediates?

    Pharmaceutical intermediates are chemical compounds which form the building blocks of active pharmaceutical ingredients (APIs). Pharmaceutical intermediates are produced as by-products during the production of an active pharmaceutical ingredient (API).

    Both active pharmaceutical ingredients (APIs) and intermediates belong to the category of fine chemicals. The main difference between the two is that the active pharmaceutical ingredient (API) is an active product that has been completely synthesized, and the intermediate is a product at a certain place in the synthesis route. 

    While active pharmaceutical ingredients (APIs) exhibit pharmacological activity or other direct effects in the diagnosis, treatment, symptom relief, or prevention of diseases, intermediates are materials produced during the synthesis of APIs, which can only be turned into API by further molecular change or refinement.

    Pharmaceutical intermediates, veterinary drug intermediates, and bulk drug intermediates are various types of drug intermediates. Drug intermediates are hygienically formulated using high-grade raw materials and they are used in the pharmaceutical industry. Pharmaceutical intermediates are also used for research and development purposes by pharmaceutical and biopharma companies. 

    While synthesizing active pharmaceutical ingredients (APIs), the pharmaceutical intermediates are exploited as chemical composites. They act as a building block in producing APIs, are involved in process development and validation to deliver quality assurance, and may help in decreasing the cost of high quality medicines.

    As per a report published by Mordor Intelligence, the pharmaceutical intermediates market is anticipated to grow with a CAGR of nearly 5.3%, during the forecast period from 2018 to 2026. Consequently, organizations around the world need to work together to supply everything from starting materials to advanced API intermediates for the production of both branded and generic drugs. 

    Most pharma companies, contract development and manufacturing organizations (CDMO), contract research organizations (CRO) and contract manufacturing organizations (CMO ) which act as pharmaceutical drug intermediate manufacturers operate at near-full manufacturing capacity, producing a wide range of API intermediates and drugs to keep up with ever-growing demands. 

    Working with a CRO, CMO, CDMO for intermediates allows drug companies to benefit from a long-term partnership with an experienced team offering specific skills, equipment and technical resources that are not available internally, resulting in a robust supply chain from clinical supply to commercial scale, reduced risks and optimized costs. 

    Q2. How do fine chemicals differ from specialty chemicals?

    Fine chemicals are single, pure and complex chemicals that are only produced in small amounts by multipurpose plants. Alternatively, fine chemicals are defined as inorganic or organic molecules produced in kilogram to multi-ton quantities by conventional or biotechnological chemical processes in plants across the world.

    Most manufacturing firms, such as a CRO, CDMO, or CMO, produce chemicals in bulk using standardized reactions. Fine chemicals, on the other hand, are produced by a limited number of companies. The developing and manufacturing process of fine chemicals is complex and usually subject to multi-step synthesis.

    Fine chemicals, to sum up, have to be combined with other substances to create products. They are also much more expensive to produce than bulk chemicals, due to their complexity and changing chemistries. These products end up in the specialty chemicals market. The specialty chemicals market includes high-value products that are produced in small quantities. 

    Fine chemicals are used as starting materials for specialty chemicals, particularly pharmaceuticals, biopharmaceuticals and agrochemicals. For instance as active ingredients in biocide formulations, as additives for plastics and coatings, or as active ingredients in cosmetics and toiletries. Some are also used as intermediates in the manufacture of liquid crystal displays, and so on. 

    As the name implies, specialty chemicals are manufactured for more specialist uses, and as a consequence are produced on a much smaller scale. Furthermore, they are sold based on functionality. Such products are temperature and pressure-sensitive thus the process, as well as storage conditions, need to be adhered to accordingly. 

    Typical specialty chemicals include additives and active ingredients. They may also include high value, low volume, ultra high purity chemicals used as intermediates for bio-pharma or high tech processing. 

    An organization such as a CRO, CMO, or CDMO experienced in the above-mentioned compounds and which functions as pharmaceutical drug intermediates manufacturer may offer fine chemical manufacturing services as well as the production of specialty chemicals from clinical supply to commercial scale. 

    Q3. How does flow chemistry help in the efficient and safe synthesis of APIs and intermediates?

    The concept of flow chemistry defines a very general range of chemical processes that occur in a continuous flowing stream, conventionally taking place in a reactor zone. Flow chemistry is also known as continuous flow or plug flow chemistry. The process offers potential for the efficient manufacture of chemical products including the efficient and safe synthesis of APIs and intermediates. 

    Flow technology was introduced to pharmaceutical manufacturing in the early 2000s, when academic scientists started to develop a flow system for active pharmaceutical ingredients (APIs) and intermediate synthesis. 

    Over almost two-decades of development, flow chemistry has evolved from a novel synthesis concept to a powerful and versatile platform for the continuous manufacturing of APIs and intermediates with high productivity, a small manufacturing footprint, and reduced costs and waste.

    In flow chemistry, reactants are combined by pumping fluids, including solutions of reagents, through tubes at known rates. The relative proportions of the reactants are controlled by their concentrations and relative flow rates. The advantages of this method over conventional batch reactions are the higher surface to volume ratio, easier heat and mass transfer resulting in more efficient reactions, and easier control and scale up. 

    Continuous operation makes it possible to minimize reaction volumes as the quantity of unstable reaction mixture in the continuous reactor at a given time is greatly reduced compared to a conventional batch process, thereby reducing safety risks. Furthermore, flow chemistry allows only a small amount of hazardous intermediate to be formed at any instant. 

    Flow chemistry is also characterized by a gain in chemical efficiency. Continuous flow reactors allow for tighter residence time distribution than batch reactors and enable excellent reaction selectivity. The rapid diffusion mixing avoids the issues found in batch reactors and high surface area to volume ratio enables almost instantaneous heating or cooling and therefore ultimate temperature control.

    These factors contribute to minimizing secondary reactions and the formation of impurities. The quality of the product is correspondingly improved and the environmental footprint of such processes is reduced drastically. 

    Flow chemistry’s benefits in terms of safety, reagents consumption, and efficiency, now make it possible to conduct difficult reactions and to produce intermediates and APIs. Given all of these advantages, it is not surprising that continuous processing is emerging as one of the techniques that can significantly impact the synthesis of API intermediates. Flow chemistry is now part of the CDMO landscape and is considered as an essential technological asset for controlling sensitive chemical reactions.


    Some Other Advantages of Flow Chemistry:

    - Flow reactors can be easily and safely pressurised. This allows reaction temperatures well above the normal boiling point of the solvents providing reaction rates 1000 times faster than under reflux conditions.

    - Testing a range of reaction variables is far faster in flow processes and less substrates and reagents are required.

    - Because of precise control over variables and the ability to safely execute reactions over a wider range of reaction conditions, overall yield is improved, while impurity levels are minimized. 

    - It is safer for manufacturing organic intermediates and APIs under continuous flow conditions, where some synthetic steps that were not permitted for safety reasons can be performed with minimum risk. 

    Q4. Which are the leading pharmaceutical CDMOs for intermediates and fine chemicals?

    Pharmaceutical innovators are today relying more and more on Contract Development and Manufacturing Organizations (CDMOs) for the clinical and commercial production (i.e. commercialization) of their APIs and intermediates, fine chemicals, specialty APIs, etc. 

    Some leading pharmaceutical drug intermediates manufacturers offering CDMO services for APIs and intermediates from clinical supply to commercial scale are noted in detail below. 


    Pfizer CentreOne - CDMO Services for APIs and Intermediates (Including Specialty APIs)

    Pfizer CentreOne, a global contract development and manufacturing organization (CDMO) and a leading supplier of intermediates and specialty APIs, offers development and manufacturing services for fine chemicals and intermediates. It therefore functions as a CDMO for intermediates and APIs. 


    Aozeal Certified Standards - Reference Standard Materials (RSMs) & Intermediates

    Aozeal Certified Standards (AOCS), Inc. is a high-tech bio-pharmaceutical company specialized in the manufacturing and supply of intermediates and other pharmaceutical reference standard materials (RSMs). It is one of the leading manufacturers of reference standard materials (RSMs) such as drug working standards, drug impurity standards, drug metabolites and stable isotope labelled compounds.


    PMC Isochem - Clinical and Commercial Production of APIs and Intermediates

    PMC Isochem offers custom development and manufacturing of fine chemical intermediates (cGMP or non cGMP), active pharmaceutical ingredients (APIs), polypeptide excipients and amino acid based biopolymers for drug delivery solutions. It also has process development and validation services as part of its service capabilities. It offers the clinical and commercial production or commercialization of intermediates, APIs, excipients and polymers. PMC therefore provides CDMO services for APIs and intermediates and can thus function as a CDMO for intermediates.


    Minakem - CDMO for Small Molecules, Fine Chemicals, HPAPIs, APIs and Intermediates

    Minakem is a CDMO for intermediates, fine chemicals and active pharmaceutical ingredients (APIs). Minakem offers a combination of innovative development and manufacturing solutions through a wide range of flexible assets, specialized technologies, and advanced process development and validation capabilities for the synthesis of APIs and intermediates as well as HPAPIs at all production scales.


    Curia - Fine Chemical Manufacturing Services

    Curia serves a variety of specialty markets such as pharmaceuticals, agriculture, cosmetics, oilfields, detergents, lithography, coatings, liquid crystals, metal treatment and fuel cells via the fine chemical manufacturing services they offer. Curia’s drug substance and drug product manufacturing capabilities encompass launch through mature commercialization. 


    Clearsynth Labs Limited - CDMO for Small Molecules

    Clearsynth functions as a CDMO for small molecules and offers small molecule manufacturing services. Chemically manufactured small molecules are the classic active drug substance that continues to be the "engine of growth" in the pharmaceutical industry.

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    Egis Pharmaceuticals PLC

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    CONTRACT MFG. FOR INTERMEDIATES & APIs

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    Egis offers a wide range of intermediate and small molecule drug substance development and manufacturing services to its pharmaceutical partners. Its multifunctional production lines utilizes organic synthesis process for intermediates & drug substances.

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    PMC Isochem

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    cGMP MANUFACTURING FOR INTERMEDIATES

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    PMC Isochem offers custom development and manufacturing of cGMP intermediates, active pharmaceutical ingredients (APIs), polypeptide excipients and amino acid-based biopolymers for drug delivery solutions.

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    Pfizer CentreOne

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    Pfizer CentreOne, a global contract development and manufacturing organization (CDMO) and a leading supplier of intermediates & specialty APIs, offers development & manufacturing of fine chemicals & intermediates.

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    CPhI North America

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    Minakem

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    Virtual BoothMinakem offers CDMO services for API & HPAPI, generics, regulatory expertise, track record performance & FDA & GMP certifications.
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    FINE CHEMICAL AND INTERMEDIATE MANUFACTURING

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    Minakem offers innovative manufacturing solutions through a range of advanced process capabilities for the synthesis of intermediates, APIs and HPAPIs. It's Beuvry-la-Forêt site is a global fine chemical manufacturer for the pharmaceutical industry.

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    Fine Chemical and Intermediate Manufacturing

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    FARMAK, a.s

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    Virtual BoothFarmak works in the development, production and marketing of APIs, Intermediates & Specialties// FDA inspected.
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    INTERMEDIATES AND SPECIALIZED CHEMICALS

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    Farmak is focused in the manufacturing and marketing of various product groups such as intermediates, specialized chemicals and active pharmaceutical ingredients.

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    Farmak Intermediates and Specialized Chemicals

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    Inabata France S.A.S

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    Virtual BoothIKF/Pharmasynthese have been with fine chemicals market and APIs performance for more than 40 years.
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    GMP FINE CHEMICAL PRODUCTION

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    Inabata's Pharmasynthese has expertise in GMP fine chemical production from pilot to commercial quantities at its multipurpose plant. Its 60 to 6,000 litre reactors are able to perform a wide range of organic synthesis reactions.

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    Inabata GMP Fine Chemical Production

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    Malladi Drugs & Pharmaceuticals Limited

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    Virtual BoothMalladi is a leader in Ephedrine, Pseudoephedrine Salts & Phenylephrine HCl // USFDA, EDQM, ANSM, KFDA, and TGA inspected.
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    INTERMEDIATE MANUFACTURING SERVICES

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    Malladi operates three cGMP manufacturing facilities for manufacturing APIs and intermediates. Its facilities can support manufacturing volumes ranging from a kilo up to multi-ton levels.

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    Malladi Drugs Intermediate Manufacturing Services

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    Gentec Pharmaceutical Group

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    FINE CHEMICAL & INTERMEDIATE MANUFACTURING

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    Gentec offers contract manufacturing of fine chemicals, advanced intermediates and active pharmaceutical ingredients (APIs) in its multifunctional plant, Duke Chem which is cGMP compliant.

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    Fine Chemical & Intermediate Manufacturing

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    ZACH System SA

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    GMP INTERMEDIATES

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    Zach's Avrillé site has expertise in the manufacturing of APIs and pharmaceutical intermediates. About 215MT of APIs and GMP intermediates are manufactured at the site each year.

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    ZACH GMP Intermediates

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    Century Pharmaceuticals

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    CONTRACT MANUFACTURING FOR INTERMEDIATES

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    Century Pharmaceuticals being an API focused manufacturing company is in the business of providing contract manufacturing for intermediates and active pharmaceutical ingredients (APIs) in the global pharmaceutical industry.

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    Century Pharmaceuticals Contract Manufacturing for Intermediates

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    Fermion Oy

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    CDMO FOR INTERMEDIATES & APIs

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    Fermion is a contract development and manufacturing organization (CDMO) comprising of three manufacturing units for intermediates and APIs along with distillery, hydrogenation, maintenance, warehouses, QC laboratory, and administrative functions.

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    CDMO for Intermediates & APIs

    CPhI North America

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    M2i Group

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    CONTRACT MANUFACTURING FOR INTERMEDIATES

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    M2i's Pharma & Chemical division is dedicated to the development and production of synthetic intermediates, specialty chemicals, active ingredients & pheromones in compliance with GMP. It also provides custom synthesis, scale-up & large-scale production.

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    M2i Group Contract Manufacturing for Intermediates

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    Tianjin Hankang Pharmaceutical Biotechnology

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      API & INTERMEDIATE MANUFACTURING

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      In 2012, Hankang built an industrial base, Tianjin Hanrui Pharmaceutical, with a full set of production lines for active pharmaceutical ingredients (APIs) and intermediates.

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      API & Intermediate Manufacturing

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      JSC Olainfarm

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      INTERMEDIATE CONTRACT MANUFACTURING

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      Olainfarm is the leading contract manufacturer in the chemical and pharmaceutical sector with more than 45 years of experience. Its portfolio contains over 60 FDFs, 25 APIs and more than 20 intermediates.

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      JSC Olainfarm Intermediate Contract Manufacturing

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      Aarti Pharmalabs

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      ADVANCED INTERMEDIATE MANUFACTURING SERVICES

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      Aarti Pharmalabs is a leading CDMO that offers contract development and manufacturing services for intermediates, RSM, NCE and drug substances.

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      Aarti Advanced Intermediate Manufacturing Services

      CPhI China

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      Evonik

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      CONTRACT MANUFACTURING FOR INTERMEDIATES

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      Evonik is one of the largest and most dependable contract manufacturing organizations for high-quality production of intermediates and active pharmaceutical ingredients (APIs).

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      Contract Manufacturing for Intermediates

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      Seqens

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      CUSTOM MANUFACTURING FOR FINE CHEMICALS

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      Seqens is a leader in the development and manufacturing of cGMP and non-cGMP intermediates. It supports early stage to commercial manufacturing of fine chemicals, advanced intermediates & highly potent intermediates with OEB 4 & 5 (1µg/m3) classification.

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      Custom Manufacturing for Fine Chemicals

      CPhI North America

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      Valsynthese

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      CDMO FOR ADVANCED INTERMEDIATES

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      Valsynthese's manufacturing facilities — both ISO and GMP certified — produce a range of advanced intermediates for fine chemicals, pharmaceutical products as well as active pharmaceutical ingredients (APIs).

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      Valsynthese CDMO for Advanced Intermediates

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      Aurigene Pharmaceutical Services

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      ADVANCED INTERMEDIATE CONTRACT MANUFACTURING

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      Aurigene Pharmaceutical Services offers a wide range of manufacturing services, from a few kilos to multi-tons for Key Starting Material (KSM) / Registered Starting Materials (RSM), advanced intermediates and APIs.

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      Aurigene Advanced Intermediate Contract Manufacturing

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      Neuland Laboratories

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      MANUFACTURING OF ADVANCED INTERMEDIATES

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      Neuland has expertise in the cGMP manufacturing of advanced intermediates and active pharmaceutical ingredients (APIs) from its USFDA-approved facilities from lab to commercial scale.

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      Pharma Service: API Manufacturing

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      Manufacturing of Advanced Intermediates

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      Axplora

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      Virtual BoothAxplora- The partner of choice for complex APIs.
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      MANUFACTURING OF ADVANCED INTERMEDIATES

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      Axplora offers best-in-class CDMO services for advanced intermediates, cGMP intermediates, specialty intermediates, and APIs from process development to clinical and commercial manufacturing.

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      Pharma Service: API Manufacturing

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      MANUFACTURING OF ADVANCED INTERMEDIATES

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      Kimia Biosciences

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        CONTRACT MANUFACTURING FOR INTERMEDIATES

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        As a contract manufacturing organization (CMO), Kimia Biosciences makes high-quality APIs & Intermediates that serve the highly regulated markets of the USA, Europe, & Japan etc.

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        Category: Fine Chemical / Intermediate

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        Contract Manufacturing for Intermediates

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        Acharya Chemicals

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        CRAMS FOR SPECIALTY CHEMICALS & INTERMEDIATES

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        Acharya Chemicals is a contract research & manufacturing service provider for specialty chemicals, intermediates and active pharmaceutical ingredients (APIs). It has a reliable chemical manufacturing facility for producing high-quality chemical products.

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        Acharya Chemicals CRAMS for Specialty Chemicals & Intermediates

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        Avra Laboratories

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        CRAMS FOR INTERMEDIATES & RSMs

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        Avra Labs is a contract research and manufacturing service (CRAMS) provider for advanced intermediates. It provides solutions for the production of intermediates, RSMs, and APIs with multi-step manufacturing processes.

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        Pharma Service: API Manufacturing

        Category: Fine Chemical / Intermediate

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        CRAMS for Intermediates & RSMs

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        Norchim

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        CRO OF ADVANCE INTERMEDIATES

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        Contract organization to provide intermediates to the pharmaceutical industry.

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        Pharma Service: API Manufacturing

        Category: Fine Chemical / Intermediate

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        Norchim CB

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        Kosher Pharmaceuticals Pvt ltd

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          SYNTHESIS OF APIs & INTERMEDIATES

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          Kosher develops novel, efficient and cost effective synthetic methodologies for APIs and intermediates of APIs by continuous research.

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          Pharma Service: API Manufacturing

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          Kekule Pharma

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          CONTRACT MANUFACTURING FOR INTERMEDIATES

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          Kekule offers API & Intermediate manufacturing. Working with customers across the world, Kekule has always leveraged its strengths in basic chemistry & chemical engineering to deliver high quality APIs & Intermediates on time & at competitive prices.

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          Shouyuan Chemical

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          INTERMEDIATES MANUFACTURING

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          Shouyuan chemical specializes in manufacturing, supplying, and custom synthesizing the latest chemicals. It covers a range of products like pharmaceuticals, agrochemicals, electronic chemicals, surfactants and other specialty chemicals.

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          Ocimum Labs

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            KSM & KEY INTERMEDIATE MANUFACTURING

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            Ocimum Labs is a contract development & manufacturing service provider which supports drug development & API manufacturing, including KSM & key intermediates for global pharma companies at all stages, from the pre-clinical stage to commercialization.

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            Robinson Brothers

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              SPECIALITY & FINE CHEMICAL INTERMEDIATES

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              Robinson Brothers is an award-winning manufacturer of speciality organic chemicals. Based in the UK, they offer chemical intermediates from gram to multi-tonne quantities.

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              SPC Lifesciences Pvt. Ltd

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                INTERMEDIATES

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                Spread across an area of 10,000 m2, SPC operates three multi-purpose manufacturing plants for basic intermediates, advanced intermediates & strategic products respectively at Ankleshwar.

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                Shouyuan Chemical

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                CUSTOM SYNTHESIS FOR SYNTHETIC PRODUCTS

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                Shouyuan chemical specializes in manufacturing, supplying, and custom synthesizing the latest chemicals. It covers a range of products like pharmaceuticals, agrochemicals, electronic chemicals, surfactants and other specialty chemicals.

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                Infinium Pharmachem

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                  INTERMEDIATES MANUFACTURING

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                  Infinium Pharmachem has been one of the most trusted suppliers of intermediates for a large number renowned pharmaceutical / biotech companies for more than a decade.

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                  Fresenius Kabi Austria

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                    INTERMEDIATES FOR ANTI-CANCER APIs

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                    Fresenius Kabi Oncology Limited has world class expertise in the development and manufacture of active pharmaceutical ingredients (APIs) & intermediates & oral & injectable finished dosage forms.

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                    Shanghai Chemspec Corporation

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                    GMP CERTIFIED INTERMEDIATES PRODUCTION

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                    Chemspec possesses one FDA-inspected GMP site in NJ, USA & two GMP workshops in its Shanghai site, which provide contract manufacture services for APIs and advanced intermediates. There custom manufacturing encompasses everything from advanced intermediates to highly complex components.

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                    Pharma Service: API Manufacturing

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                    Dishman Carbogen Amcis

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                    ADVANCED INTERMEDIATES & SPECIALITY CHEMICALS

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                    The Dishman CRAMS business offers an unparalleled range of facilities dedicated to contract manufacture of APIs, Highly Potent APIs (HPAPIs) and advanced intermediates & speciality chemicals for pharmaceutical customers.

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                    Pharma Service: API Manufacturing

                    Category: Fine Chemical / Intermediate

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                    Dr Pradeep Reddy’s Laboratories Private Limited

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                      SYNTHESIS OF APIs & INTERMEDIATES

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                      Dr Pradeep Reddy’s Laboratories offers custom contract manufacturing of APIs or intermediates by working with its partner pharmaceutical companies in India and across the globe.

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                      Pharma Service: API Manufacturing

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                      Flamma SpA

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                      INTERMEDIATES

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                      Flamma produces a wide-ranging list of generic APIs, including products like Melatonin, Minoxidil and many more. Our Active Ingredients include compounds like Asparagine. Our Intermediates consist of numerous high-value amino acid derivatives including Moc-Valine and Cbz-L-Alanine.

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                      Pharma Service: API Manufacturing

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                      Nanjing Dorra Pharmaceutical Technology Co.,Ltd

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                        INTERMEDIATES MANUFACTURING

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                        - Service Details

                        Dorrapharma is engaged in R&D, manufacture and market of intermediate, API (Active Pharmaceutical Ingredients) and formulation. We stick to raise the value both for the company and customer, and strive for serving for the society and caring of the others.

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                        Pharma Service: API Manufacturing

                        Category: Fine Chemical / Intermediate

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                        Arevipharma

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                        INTERMEDIATES MANUFACTURING

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                        Apart from the manufacturing of active pharmaceutical ingredients and its intermediates under cGMP, Arevipharma offers the custom synthesis of complex fine and special chemicals for other applications.

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                        BioSpectra

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                        FINE CHEMICAL / INTERMEDIATE

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                        BioSpectra is a US based manufacturer of Life Science Intermediates, Excipients and Active Pharmaceutical Ingredients.

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                        Sai Life Sciences Limited

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                        APIs & INTERMEDIATES MANUFACTURING

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                        Sai Life Sciences provides GMP Active Pharmaceutical Ingredients (APIs) and intermediates for late clinical phase and commercial New Chemical Entities for US, European and Japanese innovators.

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                        Pharma Service: API Manufacturing

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                        ZCL Chemicals Limited

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                        CMO FOR ADVANCED INTERMEDIATES

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                        With the best in class manufacturing facilities and state-of-the-art research platform besides our R&D we have embarked on establishing contract manufacturing organization for APIs, Advanced Intermediates & Intermediate for Controlled Substances.

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                        Pharma Service: API Manufacturing

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                        Hameln rds

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                        PRODUCTION OF INTERMEDIATES & APIs

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                        Hameln rds is equipped to provide production of intermediates and active pharmaceutical ingredients in full compliance with GMP rules. It has a production capacity of 500 kg per year.

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                        SPC Lifesciences Pvt. Ltd

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                          CONTRACT MANUFACTURING OF INTERMEDIATES

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                          We are strong partners to some of the best generic pharma companies in India and around the world for their increasing need for stringent quality, regulatory compliant and complex chemistry handling facilities.

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                          Menadiona

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                          FINE CHEMICALS & KEY INTERMEDIATES

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                          Menadiona, an independent privately-owned company, specializes in manufacturing active ingredients (APIs) and key intermediates for the pharmaceutical, veterinary, plant health and nutraceutical industries, in addition to aziridine and its derivatives.

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                          Alven Laboratories

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                          cGMP PRODUCTION OF INTERMEDIATES

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                          Alven is reliable partner for development, process optimization, scale-up and cGMP production of branded and generic API’s and intermediates.

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                          AXYNTIS Group

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                          CONTRACT MANUFACTURING FOR FINE CHEMICALS

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                          The Axyntis Group offers contract manufacturing of fine chemicals and is able to handle projects from the gram to the ton, while complying with Good Manufacturing Practices (GMP) and maintaining high hygiene, security and quality standards.

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                          Category: Fine Chemical / Intermediate

                          Sub Category: GMP Manufacturing
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                          ChemCon GmbH

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                          CONTRACT MANUFACTURING FOR FINE CHEMICALS

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                          ChemCon is a contract development and manufacturing organization (CDMO) with over 20 years of experience in the synthesis and production of fine chemicals and active pharmaceutical ingredients (APIs).

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                          Angelini Pharma

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                          FINE CHEMICAL MANUFACTURING SERVICES

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                          The Fine Chemicals Division of Angelini is fully committed to supporting its pharmaceutical clients in their API development & manufacturing programs providing dedicated personnel and tailor-made solutions to any challenge.

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                          Pharma Service: API Manufacturing

                          Category: Fine Chemical / Intermediate

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                          Orofino Pharmaceuticals Group

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                          CONTRACT MANUFACTURING OF INTERMEDIATES

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                          The RHI-Swissmedic, EU–GMP, FDA & Japan PMDA certified site of Drug’on produces active pharmaceuticals ingredients (API) & intermediates & takes care of technology transfer. The multi-purpose site can develop APIs in several therapeutic areas.

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                          KriSan Biotech

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                            CONTRACT MANUFACTURING OF INTERMEDIATES

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                            KriSan Biotech offers contract services for manufacturing of intermediates. It is capable of producing a few grams to kilograms of intermediates and active pharmaceutical ingredients (APIs).

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                            Anacipher

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                              MANUFACTURING ADVANCE INTERMEDIATE

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                              Indoco Kilo Lab facility is versatile to perform a wide variety of reactions and complete multi-stage intermediate and API processes. Multipurpose facility to manufacture Advance Intermediate for Rest of World markets.

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                              Aozeal Certified Standards

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                                CONTRACT MANUFACTURING FOR INTERMEDIATES

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                                Aozeal Certified Standards (AOCS), Inc. is a high-tech bio-pharmaceutical company specialized in the manufacturing and supply of intermediates & other pharmaceutical reference standards.

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                                Procos

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                                INTERMEDIATES & FINISHED PRODUCTS

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                                Our fully equipped, cGMP and AIFA inspected facility covers an area of more than 100,000 sq. meters and enables API production on any scale, even according to complex syntheses.

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                                Pharma Service: API Manufacturing

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                                UQUIFA

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                                PHARMACEUTICAL INTERMEDIATE MANUFACTURING

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                                Uquifa is a contract manufacturer of Active Pharmaceutical Ingredients (APIs) & intermediates for the pharmaceutical & animal health industries globally. It has been inspected & approved by leading global pharmaceutical companies & regulatory authorities.

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                                Pharma Service: API Manufacturing

                                Category: Fine Chemical / Intermediate

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                                Piramal Pharma Solutions

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                                KEY STARTING MATERIALS & GMP INTERMEDIATES

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                                Piramal offers various services such as manufacturing and supply of key starting materials (KSMs), registered starting materials (RSMs), key GMP Intermediates, high potent APIs (HPAPIs) and commercial-scale APIs.

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                                Pharma Service: API Manufacturing

                                Category: Fine Chemical / Intermediate

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                                Curia

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                                MANUFACTURING OF NON-GMP & GMP INTERMEDIATES

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                                Curia offers manufacturing of non-GMP and GMP intermediates, chemical process R&D via batch mode and continuous flow, clinical-stage APIs, biotransformations and enzymatic reactions.

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                                Pharma Service: API Manufacturing

                                Category: Fine Chemical / Intermediate

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                                Priyans Drugs

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                                  PHARMACEUTICAL INTERMEDIATES

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                                  We offer all type of pharmaceutical intermediates. We have associated with manufacturing companies as well as we are producing our intermediates contract manufacturing basis in India and china.

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                                  Grace

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                                    FINE CHEMICALS

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                                    Grace Albany Fine Chemicals' site is designed to meet customers' highest quality, regulatory, and confidentiality expectations for the manufacture of fine chemicals and intermediates.

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                                    Category: Fine Chemical / Intermediate

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                                    Anugraha Chemicals

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                                      INTERMEDIATE cGMP MANUFACTURING

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                                      Anugraha Chemicals is a GMP certified company engaged in contract manufacturing of APIs, Intermediates and Fine Chemicals. The facility houses a well equipped R&D and pilot scale lab designed to manufacture low volume-high value products.

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                                      Pharma Service: API Manufacturing

                                      Category: Fine Chemical / Intermediate

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                                      Vasudha Pharma Chem

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                                      GMP MANUFACTURING FOR INTERMEDIATES

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                                      Vasudha Pharma is exclusively focusing on manufacturing of APIs, Intermediates & piperidine derivatives. The company operates through its cGMP approved manufacturing facilities and guidelines.

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                                      Pharma Service: API Manufacturing

                                      Category: Fine Chemical / Intermediate

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                                      Pfanstiehl

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                                      CUSTOM SYNTHESIS OF ADVANCED INTERMEDIATES

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                                      Pfanstiehl synthesizes proprietary and commercial compounds in quantities ranging from grams to tons. Manufacturing and development take place within a 13-building campus located near Chicago, Illinois.

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                                      Category: Fine Chemical / Intermediate

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                                      Aragen Life Sciences

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                                      INTERMEDIATES CONTRACT MANUFACTURING

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                                      GVK BIO offers long term Contract Manufacturing services right from strategic partnerships in development, validations, DMF filing and commercial manufacturing of Active Pharmaceutical Ingredients (APIs)/advanced intermediates to APIs.

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                                      Pharma Service: API Manufacturing

                                      Category: Fine Chemical / Intermediate

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                                      Grace

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                                        INTERMEDIATES

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                                        Grace Albany Fine Chemicals' site is designed to meet customers' highest quality, regulatory, and confidentiality expectations for the manufacture of fine chemicals and intermediates.

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                                        Category: Fine Chemical / Intermediate

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                                        SIMS Srl

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                                        ADVANCED INTERMEDIATE MANUFACTURING

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                                        SIMS is a private Italian company operating in the chemical pharmaceutical sector. The main activity of the company is the production of API, but SIMS is equally involved in processing for third parties and in the production of advanced intermediates.

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                                        Pharma Service: API Manufacturing

                                        Category: Fine Chemical / Intermediate

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                                        DrugOn Pharma Switzerland

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                                          SYNTHESIS OF APIs & INTERMEDIATES

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                                          Drug’On Pharma Switzerland was the last company to be set up in the Orofino Pharmaceuticals Group. The Group bought out an ex Knoll and Abbott manufacturing site in Liestal, Switzerland. The chemical manufacturing site produces APIs and intermediates.

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                                          Pharma Service: API Manufacturing

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                                          Almelo

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                                            SPECIALTY FINE CHEMICALS

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                                            With a cumulative reactor capacity of 120 KL, our facility located at IDA Mankal is capable of producing raw materials and specialty fine chemicals to a scale of X Metric Tons per year.

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                                            Provepharm Life Solutions

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                                            CDMO FOR FINE CHEMICALS

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                                            Provepharm with over 20 years of experience as a fine chemicals CDMO offers expertise in chemistry of heterocycles and nucleosides.

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                                            Category: Fine Chemical / Intermediate

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                                            Pfanstiehl

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                                            FINE CHEMICAL MANUFACTURING

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                                            Pfanstiehl produces proprietary and public domain compounds per cGMP guidelines. From a single kilogram for clinical trials to multi-ton commercial quantities, you can trust Pfanstiehl to help you move your product quickly to market.

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                                            Category: Fine Chemical / Intermediate

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                                            Almelo

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                                              ADVANCED INTERMEDIATES & KEY RAW / STARTING MATERIAL

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                                              Our Advanced Intermediates and Key Raw/Starting Material unit is strategically located in the Industrial Development Area of Kukatpally, Hyderabad (India). This facility is spread across an area of 3 acres, comprising of 2 production blocks and pilot plants.

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                                              Farmhispania

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                                              ADVANCED INTERMEDIATES

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                                              Farmhispania Group develops and manufactures a diverse range of API’s, advanced intermediates and building blocks. Furthermore, Farmhispania Group provides PR&D and manufacturing services to support clinical trials and commercial supply.

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                                              Pharma Service: API Manufacturing

                                              Category: Fine Chemical / Intermediate

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                                              Bellen Chemistry

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                                                CONTRACT MANUFACTURING FOR KEY INTERMEDIATES

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                                                Bellen manufacturing plant at shandong, delivers key intermediates & cGMP API manufacturing services for early phase and late phase projects. The facility has a capacity of 100KL with manufacturing blocks into groups to achieve maximum flexibility.

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                                                Pharma Service: API Manufacturing

                                                Category: Fine Chemical / Intermediate

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                                                Dalton Pharma Services

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                                                  FINE CHEMICAL

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                                                  Dalton’s Custom Synthesis and Fine Chemical services offers a wide range of experience in the synthesis of low volume, high value small molecules for biotechnology and pharmaceutical applications.

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                                                  Pharma Service: API Manufacturing

                                                  Category: Fine Chemical / Intermediate

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                                                  Dalton Pharma Services

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                                                    PHARMACEUTICAL INTERMEDIATES

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                                                    Dalton’s Custom Synthesis and Fine Chemical services offers a wide range of experience in the synthesis of low volume, high value small molecules for biotechnology and pharmaceutical applications.

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                                                    Pharma Service: API Manufacturing

                                                    Category: Fine Chemical / Intermediate

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                                                    Grace

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                                                      CHIRAL INTERMEDIATES

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                                                      At Grace we have synthesized small molecule intermediates on scales up to 80 MT/year per project.

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                                                      Servier

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                                                      GMP & NON GMP COMPLIANT INTERMEDIATES

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                                                      Servier brings 60 years of experience in process development, intermediates, APIs and high-potency APIs. Its full cGMP / FDA approved chemistry network includes R&D, production and supply chain expertise with full regulatory support.

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                                                      Category: Fine Chemical / Intermediate

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