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    Chemistry

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    Also known as: 138786-67-1, Pantoloc, Protonix, Pantecta, Zurcal, Pantoprazole sodium salt
    Molecular Formula
    C16H14F2N3NaO4S
    Molecular Weight
    405.4  g/mol
    InChI Key
    YNWDKZIIWCEDEE-UHFFFAOYSA-N
    Pantoprazole Sodium
    2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER.
    1 2D Structure

    Pantoprazole Sodium

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide
    2.1.2 InChI
    InChI=1S/C16H14F2N3O4S.Na/c1-23-13-5-6-19-12(14(13)24-2)8-26(22)16-20-10-4-3-9(25-15(17)18)7-11(10)21-16;/h3-7,15H,8H2,1-2H3;/q-1;+1
    2.1.3 InChI Key
    YNWDKZIIWCEDEE-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    COC1=C(C(=NC=C1)CS(=O)C2=NC3=C([N-]2)C=CC(=C3)OC(F)F)OC.[Na+]
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. By 1023

    2. By-1023

    3. By1023

    4. Pantoprazole

    5. Protonix

    6. Sk And F 96022

    7. Sk And F-96022

    8. Sk And F96022

    9. Skf 96022

    10. Skf-96022

    11. Skf96022

    2.2.2 Depositor-Supplied Synonyms

    1. 138786-67-1

    2. Pantoloc

    3. Protonix

    4. Pantecta

    5. Zurcal

    6. Pantoprazole Sodium Salt

    7. Skf96022 Sodium

    8. By-1023 Sodium

    9. Chebi:50270

    10. Sodium;5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl]benzimidazol-1-ide

    11. Pantozol Control

    12. 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl) Sulfinyl)-1h-benzimidazole Sodium

    13. Dsstox_cid_24215

    14. Dsstox_rid_80123

    15. Dsstox_gsid_44215

    16. Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)benzo[d]imidazol-1-ide

    17. Sodium 5-(difluoromethoxy)-2-((3,4-dimethoxypyridin-2-yl)methylsulfinyl)benzo[d]imidazol-1-ide

    18. Cas-138786-67-1

    19. Anagastra

    20. Inipomp

    21. Pantorc

    22. Peptazol

    23. Ulcotenal

    24. Citrel

    25. Apton

    26. Rifun

    27. Pantoprazole Sodium;

    28. By1023 (sodium)

    29. Pantoprazole Sodium,(s)

    30. Skf96022 (sodium)

    31. Schembl3543

    32. Mls001424073

    33. Pantoprazole Sodium Monohydrate

    34. Chembl1200408

    35. Dtxsid7044215

    36. Dz-2352a

    37. Hms2051l19

    38. Hms3393l19

    39. Hms3715d12

    40. Act02633

    41. Tox21_112996

    42. Tox21_302362

    43. Mfcd01658543

    44. S4538

    45. Akos015994677

    46. Ccg-100980

    47. Ks-1093

    48. Nc00230

    49. S86p671

    50. Sb17369

    51. By-1023/sk&f-96022

    52. Ncgc00255835-01

    53. Smr000469592

    54. Ft-0602602

    55. Ft-0673508

    56. A807440

    57. B-8610-23/sk&f-96022-z

    58. J-516336

    59. B-8510-29

    60. Q27122012

    61. Sodium 5-(difluoromethoxy)-2-[(3,4-dimethoxypyridin-2-yl)methylsulfinyl] Benzimidazol-1-ide

    62. 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)sulfinyl)-1h-benzo[d]imidazole, Sodium Salt

    63. 5-(difluoromethoxy)-2-[(3,4-dimethoxy-2-pyridyl)methylsulfinyl]benzimidazol-1-ide; Sodium;pantoprazole Sodium

    64. Sodium 5-(difluoromethoxy)-2-(((3,4-dimethoxy-2-pyridinyl)methyl)sulfinyl)-1h-benzimidazole

    65. Sodium 5-(difluoromethoxy)-2-{[(3,4-dimethoxypyridin-2-yl)methyl]sulfinyl}benzimidazol-1-ide

    2.2.3 Other Synonyms

    1. Pantozol

    2. S-pantoprazole

    3. Pantoprazole

    2.3 Create Date
    2007-02-09
    3 Chemical and Physical Properties
    Molecular Weight 405.4 g/mol
    Molecular Formula C16H14F2N3NaO4S
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count10
    Rotatable Bond Count7
    Exact Mass405.05707772 g/mol
    Monoisotopic Mass405.05707772 g/mol
    Topological Polar Surface Area90.8 Ų
    Heavy Atom Count27
    Formal Charge0
    Complexity497
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count1
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count2
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 4  
    Drug NamePantoprazole sodium
    Drug LabelThe active ingredient in pantoprazole sodium delayed-release tablets USP is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid...
    Active IngredientPantoprazole sodium
    Dosage FormInjectable; Tablet, delayed release
    Routeinjection; Iv (infusion); Oral
    Strengtheq 20mg base; eq 40mg base/vial; eq 40mg base; 40mg
    Market StatusTentative Approval; Prescription
    CompanyWockhardt; Mylan Pharms; Hetero Labs Ltd V; Teva Parenteral; Teva; Apotex; Aurobindo Pharma; Torrent Pharms; Sun Pharma Global; Perrigo R And D; Actavis Elizabeth; Macleods Pharms; Jubilant Generics; Kudco Ireland; Ranbaxy Labs; Dr Reddys Labs; Akorn

    2 of 4  
    Drug NameProtonix iv
    Active IngredientPantoprazole sodium
    Dosage FormInjectable
    RouteIv (infusion)
    Strengtheq 40mg base/vial
    Market StatusPrescription
    CompanyWyeth Pharms

    3 of 4  
    Drug NamePantoprazole sodium
    Drug LabelThe active ingredient in pantoprazole sodium delayed-release tablets USP is a substituted benzimidazole, sodium 5-(difluoromethoxy)-2-[[(3,4-dimethoxy-2-pyridinyl)methyl] sulfinyl]-1H-benzimidazole sesquihydrate, a compound that inhibits gastric acid...
    Active IngredientPantoprazole sodium
    Dosage FormInjectable; Tablet, delayed release
    Routeinjection; Iv (infusion); Oral
    Strengtheq 20mg base; eq 40mg base/vial; eq 40mg base; 40mg
    Market StatusTentative Approval; Prescription
    CompanyWockhardt; Mylan Pharms; Hetero Labs Ltd V; Teva Parenteral; Teva; Apotex; Aurobindo Pharma; Torrent Pharms; Sun Pharma Global; Perrigo R And D; Actavis Elizabeth; Macleods Pharms; Jubilant Generics; Kudco Ireland; Ranbaxy Labs; Dr Reddys Labs; Akorn

    4 of 4  
    Drug NameProtonix iv
    Active IngredientPantoprazole sodium
    Dosage FormInjectable
    RouteIv (infusion)
    Strengtheq 40mg base/vial
    Market StatusPrescription
    CompanyWyeth Pharms

    4.2 Drug Indication

    Short-term treatment of reflux symptoms (e. g. heartburn, acid regurgitation) in adults.

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Anti-Ulcer Agents

    Various agents with different action mechanisms used to treat or ameliorate PEPTIC ULCER or irritation of the gastrointestinal tract. This has included ANTIBIOTICS to treat HELICOBACTER INFECTIONS; HISTAMINE H2 ANTAGONISTS to reduce GASTRIC ACID secretion; and ANTACIDS for symptomatic relief. (See all compounds classified as Anti-Ulcer Agents.)

    Proton Pump Inhibitors

    Compounds that inhibit H(+)-K(+)-EXCHANGING ATPASE. They are used as ANTI-ULCER AGENTS and sometimes in place of HISTAMINE H2 ANTAGONISTS for GASTROESOPHAGEAL REFLUX. (See all compounds classified as Proton Pump Inhibitors.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Proton Pump Inhibitors [MoA]; Proton Pump Inhibitor [EPC]
    5.3 ATC Code

    A02BC02

    API Reference Price

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    01-Jan-2022
    30-Apr-2025
    KGS
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    DOSAGE - POWDER;INTRAVENOUS - EQ 40MG BASE/VI...DOSAGE - POWDER;INTRAVENOUS - EQ 40MG BASE/VIAL

    USFDA APPLICATION NUMBER - 209463

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    DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 20...DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 20MG BASE

    USFDA APPLICATION NUMBER - 20987

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    DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 40...DOSAGE - TABLET, DELAYED RELEASE;ORAL - EQ 40MG BASE

    USFDA APPLICATION NUMBER - 20987

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    DOSAGE - INJECTABLE;INTRAVENOUS - EQ 40MG BAS...DOSAGE - INJECTABLE;INTRAVENOUS - EQ 40MG BASE/VIAL

    USFDA APPLICATION NUMBER - 20988

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    ABOUT THIS PAGE

    Looking for 138786-67-1 / Pantoprazole Sodium API manufacturers, exporters & distributors?

    Pantoprazole Sodium manufacturers, exporters & distributors 1

    12

    PharmaCompass offers a list of Pantoprazole Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Pantoprazole Sodium manufacturer or Pantoprazole Sodium supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Pantoprazole Sodium manufacturer or Pantoprazole Sodium supplier.

    PharmaCompass also assists you with knowing the Pantoprazole Sodium API Price utilized in the formulation of products. Pantoprazole Sodium API Price is not always fixed or binding as the Pantoprazole Sodium Price is obtained through a variety of data sources. The Pantoprazole Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Pantoprazole Sodium

    Synonyms

    138786-67-1, Pantoloc, Protonix, Pantecta, Zurcal, Pantoprazole sodium salt

    Cas Number

    138786-67-1

    About Pantoprazole Sodium

    2-pyridinylmethylsulfinylbenzimidazole proton pump inhibitor that is used in the treatment of GASTROESOPHAGEAL REFLUX and PEPTIC ULCER.

    Protonix Manufacturers

    A Protonix manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Protonix, including repackagers and relabelers. The FDA regulates Protonix manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Protonix API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Protonix manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Protonix Suppliers

    A Protonix supplier is an individual or a company that provides Protonix active pharmaceutical ingredient (API) or Protonix finished formulations upon request. The Protonix suppliers may include Protonix API manufacturers, exporters, distributors and traders.

    click here to find a list of Protonix suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Protonix USDMF

    A Protonix DMF (Drug Master File) is a document detailing the whole manufacturing process of Protonix active pharmaceutical ingredient (API) in detail. Different forms of Protonix DMFs exist exist since differing nations have different regulations, such as Protonix USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Protonix DMF submitted to regulatory agencies in the US is known as a USDMF. Protonix USDMF includes data on Protonix's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Protonix USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Protonix suppliers with USDMF on PharmaCompass.

    Protonix KDMF

    In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

    Pharmaceutical companies submit a Protonix Drug Master File in Korea (Protonix KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Protonix. The MFDS reviews the Protonix KDMF as part of the drug registration process and uses the information provided in the Protonix KDMF to evaluate the safety and efficacy of the drug.

    After submitting a Protonix KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Protonix API can apply through the Korea Drug Master File (KDMF).

    click here to find a list of Protonix suppliers with KDMF on PharmaCompass.

    Protonix CEP

    A Protonix CEP of the European Pharmacopoeia monograph is often referred to as a Protonix Certificate of Suitability (COS). The purpose of a Protonix CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Protonix EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Protonix to their clients by showing that a Protonix CEP has been issued for it. The manufacturer submits a Protonix CEP (COS) as part of the market authorization procedure, and it takes on the role of a Protonix CEP holder for the record. Additionally, the data presented in the Protonix CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Protonix DMF.

    A Protonix CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Protonix CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

    click here to find a list of Protonix suppliers with CEP (COS) on PharmaCompass.

    Protonix WC

    A Protonix written confirmation (Protonix WC) is an official document issued by a regulatory agency to a Protonix manufacturer, verifying that the manufacturing facility of a Protonix active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting Protonix APIs or Protonix finished pharmaceutical products to another nation, regulatory agencies frequently require a Protonix WC (written confirmation) as part of the regulatory process.

    click here to find a list of Protonix suppliers with Written Confirmation (WC) on PharmaCompass.

    Protonix NDC

    National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Protonix as an active pharmaceutical ingredient (API).

    Finished drug products

    The FDA updates the NDC directory daily. The NDC numbers for Protonix API and other APIs are published in this directory by the FDA.

    Unfinished drugs

    The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

    Pharmaceutical companies that manufacture Protonix as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

    Compounded drug products

    The NDC directory also contains data on finished compounded human drug products that contain Protonix and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Protonix NDC to their finished compounded human drug products, they may choose to do so.

    click here to find a list of Protonix suppliers with NDC on PharmaCompass.

    Protonix GMP

    Protonix Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

    GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

    PharmaCompass offers a list of Protonix GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Protonix GMP manufacturer or Protonix GMP API supplier for your needs.

    Protonix CoA

    A Protonix CoA (Certificate of Analysis) is a formal document that attests to Protonix's compliance with Protonix specifications and serves as a tool for batch-level quality control.

    Protonix CoA mostly includes findings from lab analyses of a specific batch. For each Protonix CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

    Protonix may be tested according to a variety of international standards, such as European Pharmacopoeia (Protonix EP), Protonix JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Protonix USP).

    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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