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Find Drugs for Trauma (Emergency, Injury, Surgery) in Phase II Clinical Development in UNITED STATES

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            Lead Product(s): Elezanumab

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: ABT-555

            Highest Development Status: Phase II Product Type: Large molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable September 28, 2020

            Details:

            Elezanumab is a monoclonal antibody of the human immunoglobulin (Ig)G1 isotype that binds selectively to repulsive guidance molecule A (RGMa). Elezanumab is being investigated to treat spinal cord injuries, multiple sclerosis and acute ischemic stroke.

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            Lead Product(s): Sucroferric Oxyhydroxide,Stannus Protoporphyrin

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: RBT-1

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable March 11, 2021

            Details:

            This Phase 2 study will evaluate the efficacy of RBT-1 in generating a preconditioning response as measured by a composite of biomarkers in subjects who are at risk for AKI following cardiac surgery.

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            Lead Product(s): Sucroferric Oxyhydroxide,Stannus Protoporphyrin

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: RBT-1

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 25, 2021

            Details:

            Rénibus Therapeutics will present Phase 1b clinical trial data on RBT-1, its investigational treatment for the prevention of acute kidney injury (AKI), at the Acute Kidney Injury & Continuous Renal Replacement Therapy (AKI & CRRT) 2021 Conference.

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            Lead Product(s): Sevoflurane

            Therapeutic Area: Trauma (Emergency, Injury, Surgery) Product Name: VPX638

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: National Institute of Arthritis and Musculoskeletal and Skin Diseases

            Deal Size: $1.5 million Upfront Cash: Undisclosed

            Deal Type: Funding November 11, 2020

            Details:

            The Phase II SBIR funding will be used to develop a formulation of VPX638 (sevoflurane) and to further characterize the anti-inflammatory and analgesic profile in animal disease models.

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