
Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target

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Lead Product(s) : Undisclosed
Therapeutic Area : Nutrition and Weight Loss
Study Phase : Discovery Platform
Sponsor : Novo Nordisk
Deal Size : $550.0 million
Deal Type : Collaboration
Replicate Bioscience Announces Partnership with Novo Nordisk to Unlock RNA Therapies
Details : Under the terms of the agreement, Novo Nordisk and Replicate will collaborate on certain targets for obesity, type 2 diabetes and other cardiometabolic diseases.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
August 28, 2025
Lead Product(s) : Undisclosed
Therapeutic Area : Nutrition and Weight Loss
Highest Development Status : Discovery Platform
Sponsor : Novo Nordisk
Deal Size : $550.0 million
Deal Type : Collaboration

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Lead Product(s) : RBI-4000
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Replicate Bioscience Announces Positive Results for Next-Generation srRNA Technology
Details : RBI-4000 is a novel self-replicating RNA (srRNA) vaccine candidate, which stimulate virus-neutralizing immune responses to rabies. It is being developed for the treatment of rabies infection.
Product Name : Undisclosed
Product Type : Vaccine
Upfront Cash : Inapplicable
February 14, 2024
Lead Product(s) : RBI-4000
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : RBI-4000
Therapeutic Area : Undisclosed
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
A Study of RBI-4000 in Healthy Participants
Details : RBI-4000 is a Vaccine drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of undefined medical condition.
Product Name : Undisclosed
Product Type : Vaccine
Upfront Cash : Inapplicable
September 21, 2023
Lead Product(s) : RBI-4000
Therapeutic Area : Undisclosed
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : RBI-4000
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Curia
Deal Size : Inapplicable
Deal Type : Inapplicable
Curia Supports Replicate Bioscience's Phase 1 Clinical Trial of Novel Next-Generation RNA Vaccine
Details : RBI-4000, is a self-replicating (srRNA) rabies vaccine, which is investigated in a Phase 1 clinical study utilizing clinical material developed as part of the collaboration with Curia.
Product Name : Undisclosed
Product Type : Vaccine
Upfront Cash : Inapplicable
September 13, 2023
Lead Product(s) : RBI-4000
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Curia
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : RBI-4000
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable
Replicate Bioscience Initiates a Phase 1 Trial of its Next-Generation srRNA Vaccine
Details : RBI-4000, is an next generation srRNA technology vaccine developed to stimulate virus-neutralizing immune responses to rabies virus for prophylactic use.
Product Name : Undisclosed
Product Type : Vaccine
Upfront Cash : Inapplicable
September 12, 2023
Lead Product(s) : RBI-4000
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Undisclosed
Deal Size : Inapplicable
Deal Type : Inapplicable

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Lead Product(s) : RBI-1000
Therapeutic Area : Oncology
Study Phase : Preclinical
Recipient : Precision NanoSystems
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Precision NanoSystems and Replicate Bioscience in Licensing Deal to Scale up Genomic Medicines
Details : In this licensing agreement, PNI will provide lipid nanoparticle solutions for scale-up and manufacture of up to 15 Replicate srRNA therapeutics, including RBI-1000. The terms include aggregated milestone fees, royalties, and sublicensing income sharing.
Product Name : Undisclosed
Product Type : Oligonucleotide
Upfront Cash : Undisclosed
July 26, 2022
Lead Product(s) : RBI-1000
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Recipient : Precision NanoSystems
Deal Size : Undisclosed
Deal Type : Licensing Agreement

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Lead Product(s) : Undisclosed
Therapeutic Area : Immunology
Study Phase : Preclinical
Recipient : Curia
Deal Size : Undisclosed
Deal Type : Collaboration
Details : As part of the collaboration, Curia’s experienced process development team will support the GMP production of Replicate Bioscience’s srRNA vectors up to eight-liter scale (8L), which can be used in Phase 1 through pivotal clinical trials.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
June 09, 2022
Lead Product(s) : Undisclosed
Therapeutic Area : Immunology
Highest Development Status : Preclinical
Recipient : Curia
Deal Size : Undisclosed
Deal Type : Collaboration

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Lead Product(s) : RBI-5000
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Discovery
Recipient : Immunomic Therapeutics
Deal Size : Undisclosed
Deal Type : Licensing Agreement
Replicate Bioscience and Immunomic Therapeutics Form Collaboration
Details : ITI and Replicate will develop candidates combining ITI’s UNITE technology with Replicate’s scalable self-replicating RNA (SynRGY technology) for COVID-19, HPV, and EBV.
Product Name : Undisclosed
Product Type : Vaccine
Upfront Cash : Undisclosed
June 24, 2020
Lead Product(s) : RBI-5000
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Discovery
Recipient : Immunomic Therapeutics
Deal Size : Undisclosed
Deal Type : Licensing Agreement
