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                          Therapeutic Area by Lead Product

                          Study Phase by Lead Product

                          Company by Lead Product

                          Top Deals by Deal Size (USD bn)

                          01

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : RP-6306 (lunresertib), a first-in-class, selective and potent oral small molecule inhibitor of PKMYT1, is being developed in combination with Camonsertib for the treatment of endometrial cancer.

                          Product Name : RP-6306

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          December 12, 2024

                          Lead Product(s) : Lunresertib,Camonsertib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : TH1902 (sudocetaxel zendusortide) is a peptide-drug conjugate that targets SORT1. It is being developed for treatment of high-grade serous ovarian cancer, including high-grade fallopian tube cancer.

                          Product Name : TH1902

                          Product Type : Peptide-drug Conjugate

                          Upfront Cash : Inapplicable

                          December 09, 2024

                          Lead Product(s) : Sudocetaxel Zendusortide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : The company will advance its discovery, preclinical and clinical assets, including BVX-0918 in oncology, antigen desensitization, and other immunological fields based on the DPX technology.

                          Product Name : BVX-0918

                          Product Type : Vaccine

                          Upfront Cash : Undisclosed

                          November 09, 2024

                          Lead Product(s) : BVX-0918

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : $0.3 million

                          Deal Type : Private Placement

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                          04

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : RP-6306 (lunresertib) in combination with RP-3500 (camonsertib) is being evaluated for the treatment of multiple advanced solid tumors types.

                          Product Name : RP-6306

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 23, 2024

                          Lead Product(s) : Lunresertib,Camonsertib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : ZW171 is a bispecific antibody designed to enable T cell-mediated tumor cell killing through simultaneous binding to MSLN protein on tumor cells and the engagement of CD3 on T cells.

                          Product Name : ZW171

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          October 21, 2024

                          Lead Product(s) : ZW171

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : RP-3467 is a Polθ ATPase inhibitor, small molecule drug candidate, which is being evaluated in combination with olaparib for the treatment of advanced solid tumors.

                          Product Name : RP-3467

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 14, 2024

                          Lead Product(s) : RP-3467,Olaparib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : ZW191 is a novel folate receptor-targeted topoisomerase I inhibitor ADC. Currently, it is being evaluated in the treatment of FR-alpha-expressed ovarian, endometrial, and lung cancers.

                          Product Name : ZW191

                          Product Type : Other Large Molecule

                          Upfront Cash : Inapplicable

                          May 11, 2024

                          Lead Product(s) : ZW191

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : RP-6306 (lunresertib), an oral PKMYT1 inhibitor, is being developed in combination with Debio 0123, a selective WEE1 kinase inhibitor, for treating advanced solid tumors.

                          Product Name : RP-6306

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 30, 2024

                          Lead Product(s) : Lunresertib,Debio 0123

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Debiopharm

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : FDA granted Fast Track designation to RP-6306 (lunresertib) in combination with RP-3500 (camonsertib) for CCNE1 amplified, or FBXW7 or PPP2R1A-mutated platinum-resistant ovarian cancer.

                          Product Name : RP-6306

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          April 06, 2024

                          Lead Product(s) : Lunresertib,Camonsertib

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : TH1902 is an investigational, first-in-class PDC that targets SORT1, being developed for high-grade serous ovarian, fallopian tube, or endometrioid cancer.

                          Product Name : TH1902

                          Product Type : Peptide-drug Conjugate

                          Upfront Cash : Inapplicable

                          March 21, 2024

                          Lead Product(s) : Sudocetaxel Zendusortide

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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