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    [{"orgOrder":0,"company":"Instil Bio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cytotoxic Drug","year":"2020","type":"Inapplicable","leadProduct":"Cyclophosphamide","moa":"DNA","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Instil Bio","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Instil Bio \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"Instil Bio \/ Undisclosed"},{"orgOrder":0,"company":"Instil Bio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"ITIL-306","moa":"Folate-alpha receptor","graph1":"Oncology","graph2":"Phase I","graph3":"Instil Bio","amount2":0,"highestDevelopmentShortName":"Ph 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Undisclosed"},{"orgOrder":0,"company":"Instil Bio","sponsor":"ImmuneOnco","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"CHINA","productType":"Undisclosed","year":"2024","type":"Licensing Agreement","leadProduct":"IMM2510","moa":"PD-L1\/VEGF","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"Instil Bio","amount2":2.0499999999999998,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":2.0499999999999998,"dosageForm":"Undisclosed","sponsorNew":"Instil Bio \/ Instil Bio","highestDevelopmentStatusID":"7","companyTruncated":"Instil Bio \/ Instil Bio"},{"orgOrder":0,"company":"Instil Bio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"Cisplatin","moa":"||PD-L1\/VEGF","graph1":"Oncology","graph2":"Phase II","graph3":"Instil Bio","amount2":0,"highestDevelopmentShortName":"Ph 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Bio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"ITIL-168","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"Instil Bio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Instil Bio \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Instil Bio \/ Undisclosed"},{"orgOrder":0,"company":"Instil Bio","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2021","type":"Inapplicable","leadProduct":"ITIL-168","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"Instil Bio","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Instil Bio \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Instil Bio \/ Undisclosed"},{"orgOrder":0,"company":"Instil Bio","sponsor":"Renaissance Capital","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"U.S.A","productType":"Cell & Gene Therapy","year":"2021","type":"Public Offering","leadProduct":"ITIL-168","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"Instil Bio","amount2":0.31,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0.31,"dosageForm":"Infusion","sponsorNew":"Instil Bio \/ Renaissance Capital","highestDevelopmentStatusID":"8","companyTruncated":"Instil Bio \/ Renaissance Capital"},{"orgOrder":0,"company":"Instil Bio","sponsor":"Axion Bio","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Inapplicable","leadProduct":"Palverafusp Alpha","moa":"PDL1\/VEGF","graph1":"Oncology","graph2":"Phase I","graph3":"Instil Bio","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"Instil Bio \/ Axion Bio","highestDevelopmentStatusID":"6","companyTruncated":"Instil Bio \/ Axion Bio"}]

    Find Clinical Drug Pipeline Developments & Deals by Instil Bio

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                            01

                            Instil Bio

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                            Lead Product(s) : Palverafusp Alpha

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Axion Bio

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Study to Assess AXN-2510 Treatment in Adult Patients With Advanced Solid Tumors

                            Details : Palverafusp Alpha is a Antibody, Unconjugated drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Antibody, Unconjugated

                            Upfront Cash : Inapplicable

                            September 08, 2025

                            Lead Product(s) : Palverafusp Alpha

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Axion Bio

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Instil Bio

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                            ISPE Annual Meeting
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                            Lead Product(s) : IMM2510,Cisplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Instil Bio Announces Clinical Progress for IMM2510/SYN-2510 in China

                            Details : IMM2510/SYN-2510 is a PD-L1xVEGF bispecific antibody, being investigated in combination with chemotherapy in patients with advanced non-small cell lung cancer.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : Inapplicable

                            January 14, 2025

                            Lead Product(s) : IMM2510,Cisplatin,Pemetrexed

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Instil Bio

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                            ISPE Annual Meeting
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                            Lead Product(s) : IMM2510

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : ImmuneOnco

                            Deal Size : $2,050.0 million

                            Deal Type : Licensing Agreement

                            DEALS_DEV arrow-down

                            Instil Bio and ImmuneOnco Announce License Agreement for IMM2510 and IMM27M Antibodies

                            Details : Instil is the in-licensing agreement with ImmuneOnc for ex-China development and commercial rights of ImmueOnco’s PD-L1xVEGF bispecific antibody, IMM2510 for the treating advanced solid tumors.

                            Product Name : Undisclosed

                            Product Type : Undisclosed

                            Upfront Cash : $50.0 million

                            August 01, 2024

                            Lead Product(s) : IMM2510

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : ImmuneOnco

                            Deal Size : $2,050.0 million

                            Deal Type : Licensing Agreement

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                            04

                            Instil Bio

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                            ISPE Annual Meeting
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                            ISPE Annual Meeting
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                            Lead Product(s) : ITIL-306,Cyclophosphamide,Fludarabine Phosphate

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Instil Bio Announces Resumption of Clinical Trial of CoStAR-TIL Candidate ITIL-306 in Lung, Ovarian, and Renal...

                            Details : ITIL-306 is an autologous TIL cell therapy engineered with CoStAR molecule (activated by folate receptor alpha), which enhances the cytokine release, cytolytic activity, and proliferation of TILs in the tumor microenvironment.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            January 09, 2023

                            Lead Product(s) : ITIL-306,Cyclophosphamide,Fludarabine Phosphate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            05

                            Instil Bio

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                            ISPE Annual Meeting
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                            Lead Product(s) : ITIL-168

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Instil Bio Announces Voluntary Pause of Enrollment in Ongoing Clinical Trials Related to Manufacturing

                            Details : ITIL-168 is an investigational, autologous cell therapy made from tumor infiltrating lymphocytes, or TILs. ITIL-168 is manufactured with Instil’s proprietary, which has been designed to capture and preserve the maximum diversity of each patient’s TIL...

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            October 31, 2022

                            Lead Product(s) : ITIL-168

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            06

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                            ISPE Annual Meeting
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                            Lead Product(s) : ITIL-306

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Instil Bio Announces First Patient Dosed with ITIL-306, our First Engineered TIL Therapy Using the CoStAR Plat...

                            Details : ITIL-306 is an autologous TIL cell therapy engineered with a novel and proprietary CoStAR molecule that is activated by folate receptor alpha (FRα) to provide robust costimulatory signals within the tumor microenvironment.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            October 18, 2022

                            Lead Product(s) : ITIL-306

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Instil Bio

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                            ISPE Annual Meeting
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                            Lead Product(s) : ITIL-306

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ITIL-306 in Advanced Solid Tumors

                            Details : ITIL-306 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Carcinoma, Ovarian Epithelial.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            May 31, 2022

                            Lead Product(s) : ITIL-306

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Instil Bio

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                            ISPE Annual Meeting
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                            ISPE Annual Meeting
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                            Lead Product(s) : ITIL-306,Cyclophosphamide,Fludarabine Phosphate

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Instil Bio Announces IND Clearance of First CoStAR-TIL program, ITIL-306, Designed to Enhance Activity in the ...

                            Details : ITIL-306 is an autologous TIL cell therapy engineered with a novel and proprietary Costimulatory Antigen Receptor (CoStAR) that is activated by folate receptor alpha (FRα) to provide robust costimulatory signals.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            May 27, 2022

                            Lead Product(s) : ITIL-306,Cyclophosphamide,Fludarabine Phosphate

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Instil Bio

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                            ISPE Annual Meeting
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                            Lead Product(s) : ITIL-168

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ITIL-168 in Advanced Solid Tumors

                            Details : ITIL-168 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Uterine Cervical Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            May 26, 2022

                            Lead Product(s) : ITIL-168

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Instil Bio

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                            ISPE Annual Meeting
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                            Lead Product(s) : ITIL-168

                            Therapeutic Area : Oncology

                            Study Phase : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            ITIL-168 in Advanced Melanoma

                            Details : ITIL-168 is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Melanoma.

                            Product Name : Undisclosed

                            Product Type : Cell & Gene Therapy

                            Upfront Cash : Inapplicable

                            September 20, 2021

                            Lead Product(s) : ITIL-168

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase II

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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