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Lilly","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"LY3537021","moa":"Gastric inhibitory polypeptide receptor (GIPR)","graph1":"Gastroenterology","graph2":"Phase II","graph3":"Eli Lilly","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Eli Lilly \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Eli Lilly \/ Undisclosed"},{"orgOrder":0,"company":"NGM Biopharmaceuticals","sponsor":"Michael Camilleri, MD","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Peptide, Unconjugated","year":"2021","type":"Inapplicable","leadProduct":"Aldafermin","moa":"FGFR4-KLB | FGF1\/KLB","graph1":"Gastroenterology","graph2":"Phase II","graph3":"NGM Biopharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Solution","sponsorNew":"NGM Biopharmaceuticals \/ Michael Camilleri, MD","highestDevelopmentStatusID":"8","companyTruncated":"NGM Biopharmaceuticals \/ Michael Camilleri, MD"},{"orgOrder":0,"company":"Forest Laboratories","sponsor":"Spencer Dorn, MD, MPH","pharmaFlowCategory":"DU","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Miscellaneous","year":"2011","type":"Inapplicable","leadProduct":"Milnacipran","moa":"Norepinephrine transporter","graph1":"Gastroenterology","graph2":"Phase II","graph3":"Forest Laboratories","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Gastroenterology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Forest Laboratories \/ Spencer Dorn, MD, MPH","highestDevelopmentStatusID":"8","companyTruncated":"Forest Laboratories \/ Spencer Dorn, MD, MPH"},{"orgOrder":0,"company":"Spyre Therapeutics","sponsor":"Jefferies | Leerink Partners | Stifel | Nicolaus & Company","pharmaFlowCategory":"D","therapeuticArea":"Gastroenterology","country":"U.S.A","productType":"Antibody, Unconjugated","year":"2025","type":"Public Offering","leadProduct":"SPY001","moa":"Alpha-4-beta-7 integrin","graph1":"Gastroenterology","graph2":"Phase II","graph3":"Spyre Therapeutics","amount2":0.28000000000000003,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Gastroenterology","amount2New":0.28000000000000003,"dosageForm":"Injection","sponsorNew":"Spyre Therapeutics \/ Jefferies | Leerink Partners | Stifel | Nicolaus & Company","highestDevelopmentStatusID":"8","companyTruncated":"Spyre Therapeutics \/ Jefferies | Leerink Partners | Stifel | Nicolaus & Company"}]

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          Details : Linaclotide is a Peptide drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Constipation.

                          Product Name : Undisclosed

                          Product Type : Peptide, Unconjugated

                          Upfront Cash : Inapplicable

                          March 08, 2023

                          Lead Product(s) : Linaclotide

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase II

                          Sponsor : Ironwood Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          02

                          Details : Botulinum Toxin Type A is a Protein drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Hernia, Ventral.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          November 07, 2022

                          Lead Product(s) : Botulinum toxin type A

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          03

                          Details : Eluxadoline is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Irritable Bowel Syndrome.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          November 13, 2017

                          Lead Product(s) : Eluxadoline

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          04

                          Details : Eluxadoline is a Other Small Molecule drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Irritable Bowel Syndrome.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          May 25, 2010

                          Lead Product(s) : Eluxadoline

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Abbvie Company Banner

                          05

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Lead Product(s) : SPY001

                          Therapeutic Area : Gastroenterology

                          Study Phase : Phase II

                          Sponsor : Jefferies | Leerink Partners | Stifel | Nicolaus & Company

                          Deal Size : $275.0 million

                          Deal Type : Public Offering

                          Details : The proceeds from the offering will used to fund the clinical development of SPY001, the focus is on targeting Alpha-4-beta-7 integrin for IBD treatment.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          October 13, 2025

                          Lead Product(s) : SPY001

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase II

                          Sponsor : Jefferies | Leerink Partners | Stifel | Nicolaus & Company

                          Deal Size : $275.0 million

                          Deal Type : Public Offering

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                          06

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : (LY3537021) is currently being evaluated in Phase II clinical studies for the treatment of Nausea.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          September 12, 2025

                          Lead Product(s) : LY3537021

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : MT-501 is a drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Inflammatory Bowel Diseases.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          August 08, 2025

                          Lead Product(s) : MT-501

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : The proceeds from the offering will be used to fund the clinical development of FB-102, which is being evaluated for the treatment of celiac disease.

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Undisclosed

                          June 25, 2025

                          Lead Product(s) : FB-102

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase II

                          Sponsor : TD Cowen

                          Deal Size : $75.0 million

                          Deal Type : Public Offering

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                          09

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : The agreement grants Intact the exclusive option to license PCS12852, a best-in-class 5-HT4 receptor agonist for gastroparesis and other gastrointestinal motility disorders.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Undisclosed

                          June 17, 2025

                          Lead Product(s) : PCS12852

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase II

                          Sponsor : Intact Therapeutics

                          Deal Size : $455.0 million

                          Deal Type : Licensing Agreement

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                          10

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : FB102 is a drug candidate, which is currently being evaluated in Phase II clinical studies for the treatment of Celiac Disease.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          May 21, 2025

                          Lead Product(s) : FB102

                          Therapeutic Area : Gastroenterology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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