[{"orgOrder":0,"company":"Axalbion","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2024","type":"Inapplicable","leadProduct":"AX-8","moa":"TRPM8","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II","graph3":"Axalbion","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Axalbion \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Axalbion \/ Inapplicable"},{"orgOrder":0,"company":"Axalbion","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2021","type":"Inapplicable","leadProduct":"AX-8","moa":"TRPM8","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II","graph3":"Axalbion","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Oral Tablet, Orally Disintegrating","sponsorNew":"Axalbion \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Axalbion \/ Inapplicable"},{"orgOrder":0,"company":"Axalbion","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Pulmonary\/Respiratory Diseases","country":"UNITED KINGDOM","productType":"Other Small Molecule","year":"2022","type":"Inapplicable","leadProduct":"AX-8","moa":"TRPM8","graph1":"Pulmonary\/Respiratory Diseases","graph2":"Phase II","graph3":"Axalbion","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Respiratory Diseases","amount2New":0,"dosageForm":"Oral Tablet, Orally Disintegrating","sponsorNew":"Axalbion \/ Inapplicable","highestDevelopmentStatusID":"8","companyTruncated":"Axalbion \/ Inapplicable"}]

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                          01

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : AX-8 is a potent and selective oral agonist of the transient receptor potential melastatin 8 (TRPM8) ion channel, which is being evaluated for the treatment of chronic cough.

                          Product Name : AX-8

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          August 27, 2024

                          Lead Product(s) : AX-8

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : Treatment with AX-8 40 mg BID compared to placebo showed a reduction in cough frequency within the first 15 minutes after treatment and lasting for more than 4 hours.

                          Product Name : AX-8

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          June 29, 2022

                          Lead Product(s) : AX-8

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Pharmex
                          Not Confirmed
                          Pharmex
                          Not Confirmed

                          Details : AX-8 is potent and selective oral agonist of the transient receptor potential melastatin 8 (TRPM8) ion channel has a novel mechanism of action targeting the TRPM8 ion channel, help normalize upper airway sensitivity in chronic cough patients.

                          Product Name : AX-8

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          October 20, 2021

                          Lead Product(s) : AX-8

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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