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Giunta"},{"orgOrder":0,"company":"Regeneron Pharmaceuticals","sponsor":"David M. 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Kokame, MD","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2013","type":"Inapplicable","leadProduct":"Aflibercept","moa":"Vascular endothelial growth factor A | Placenta growth factor","graph1":"Ophthalmology","graph2":"Phase IV","graph3":"Regeneron Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Regeneron Pharmaceuticals \/ Gregg T. Kokame, MD","highestDevelopmentStatusID":"11","companyTruncated":"Regeneron Pharmaceuticals \/ Gregg T. Kokame, MD"},{"orgOrder":0,"company":"Regeneron Pharmaceuticals","sponsor":"Justis Ehlers","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"U.S.A","productType":"Protein","year":"2015","type":"Inapplicable","leadProduct":"Aflibercept","moa":"Vascular endothelial growth factor A | Placenta growth factor","graph1":"Ophthalmology","graph2":"Phase IV","graph3":"Regeneron Pharmaceuticals","amount2":0,"highestDevelopmentShortName":"Ph IV","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Regeneron Pharmaceuticals \/ Justis Ehlers","highestDevelopmentStatusID":"11","companyTruncated":"Regeneron Pharmaceuticals \/ Justis Ehlers"},{"orgOrder":0,"company":"Bayer AG","sponsor":"Hyewon Chung","pharmaFlowCategory":"DU","therapeuticArea":"Ophthalmology","country":"GERMANY","productType":"Protein","year":"2018","type":"Inapplicable","leadProduct":"Aflibercept","moa":"Vascular endothelial growth factor A | Placenta growth factor","graph1":"Ophthalmology","graph2":"Approved FDF","graph3":"Bayer AG","amount2":0,"highestDevelopmentShortName":"Approved FDF","therapeuticAreaShortName":"Ophthalmology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Bayer AG \/ Hyewon Chung","highestDevelopmentStatusID":"15","companyTruncated":"Bayer AG \/ Hyewon Chung"},{"orgOrder":0,"company":"Regeneron Pharmaceuticals","sponsor":"Jeffrey S. 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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Study Phase : Phase II

                          Sponsor : CR-CSSS Champlain-Charles-Le Moyne

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Aflibercept is a Protein drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Colorectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          January 24, 2014

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : CR-CSSS Champlain-Charles-Le Moyne

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          02

                          Details : Aflibercept is a Protein drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Colorectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          October 07, 2013

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          03

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Aflibercept is a Protein drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          August 29, 2013

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          04

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Study Phase : Phase II

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Aflibercept is a Protein drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Colorectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          June 20, 2013

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          05

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Aflibercept is a Protein drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Colorectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          August 22, 2012

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          06

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Aflibercept is a Protein drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Colorectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          August 09, 2012

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          07

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Study Phase : Phase II

                          Sponsor : John Hays

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Aflibercept is a Protein drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Colonic Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          July 27, 2012

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : John Hays

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          08

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Study Phase : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Aflibercept is a Protein drug candidate, which is currently being evaluated in phase III clinical studies for the treatment of Colorectal Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          April 05, 2012

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase III

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          09

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Study Phase : Phase I

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Aflibercept is a Protein drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasms.

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          June 22, 2010

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Regeneron Pharmaceuticals

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Sanofi Company Banner

                          10

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : Through the licensing for Aflibercept, a protein targeting Vascular endothelial growth factor A and Placenta growth factor, the agreement aims to advance treatment for wet AMD.

                          Product Name : 4D-150

                          Product Type : Protein

                          Upfront Cash : $85.0 million

                          October 30, 2025

                          Lead Product(s) : Aflibercept

                          Therapeutic Area : Ophthalmology

                          Highest Development Status : Phase III

                          Sponsor : Otsuka Pharmaceutical

                          Deal Size : $471.0 million

                          Deal Type : Licensing Agreement

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