Our scientific efforts are aimed at developing drugs that improve the management of proliferative diseases of the bone marrow. Our clinical focus is on acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), polycythemia vera (PV), myelofibrosis (MF) and essential thrombocythemia (ET) – diseases sharing several features. These diseases are caused by acquired mutations in blood stem cells. These mutations drive excessiv...
Our scientific efforts are aimed at developing drugs that improve the management of proliferative diseases of the bone marrow. Our clinical focus is on acute myeloid leukemia (AML), myelodysplastic syndrome (MDS), polycythemia vera (PV), myelofibrosis (MF) and essential thrombocythemia (ET) – diseases sharing several features. These diseases are caused by acquired mutations in blood stem cells. These mutations drive excessive growth and alter the function of specific bone marrow cells. In the case of myelofibrosis, mutant megakaryocytes, the cells that make platelets, are a central cell type driving disease.
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