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    Enhancing Patient Experience UltraBurst™The Ultimate ODT Solution

    03 Feb 2025

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    Beyond Pharma: SPI Pharma’s Impact Across Industries

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    SPI Pharma & Inimmune to Develop &Commercialize Vaccine Adjuvant

    17 Jul 2024

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    For over 75 years, SPI Pharma has been supplying highly engineered products and innovative solutions to the pharmaceutical and nutritional industries to improve the formulation and delivery of drug products to meet patient needs. Owned by Associated British Foods, SPI Pharma has established itself as a global leader, serving over 55 countries in the manufacture and marketing of antacid actives, specialty excipients, drug delivery systems and taste-masking technology for solid oral and oral dispersible dosage forms.

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    VLOG #PharmaReel

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    ReelPharmaSolving Formulation Challenges with Superior Functional MaterialSolving Formulation Challenges with Superior Functional Material

    Solving Formulation Challenges with Superior Functional Material
    Solving Formulation Challenges with Superior Functional Material

    reelSolving Formulation Challenges with Superior Functional Material

    Formulation challenges? We've got solutions. Explore our innovative functional materials for mineral supplements, taste masking, chewable tablets and softgel formulations.

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    CORPORATE CONTENT #SupplierSpotlight

    Product List 2023

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    Corporate Presentation

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    GMP Certificate 2024

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    Sorbitol Special®

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    SIM 100 DC Simethicone Powder

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    Pharmasperse® 416

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    Pharmaburst® 500

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    Magnesium Hydroxide Powders

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    Magnesium Hydroxide Pastes

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    Mannogem® XL Mannitol

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    Mannogem® Mannitol

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    Lubripharm® SSF Sodium Stearyl Fumarate

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    Effer-Soda® Sodium Bicarbonate

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    Directly Compressible Sugars

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    Compressol® SM Co Processed Polyol

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    CoBlend Grades Aluminum & Magnesium Hydroxide

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    AHMH 3535 Aluminum & Magnesium Hydroxide

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    Advantose® FS95 Directly Compressible Fructose

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    Advantose® 100 Maltose Powder

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    Advantol® 300

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    Orally Dispersible Technologies

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    Vaccine Adjuvants

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    Actimask® Taste Masked Actives

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    Distribution Partnership between SPI Pharma & Ingredientpharm

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    Pharmasolutions

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    DATA COMPILATION #PharmaFlow

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    Excipient Market Overview: Roquette announces restructuring post IFF Pharma buyout; WHO, FDA advance regulatory frameworks

    Excipient Market Overview: Roquette announces restructuring post IFF Pharma buyout; WHO, FDA advance regulatory frameworks

    The pharmaceutical excipients market saw significant strategic consolidations, technological developments, and regulatory adaptations in 2025. Globally, the pharmaceutical excipients sector is growing at a compound annual growth rate of 6.6 percent, and was valued at US$ 8.85 billion in 2024. It is projected to reach US$ 14.77 billion by 2032.This year, the sector is witnessing technological advancements, regulatory evolution, and strategic business realignments. North America continues to dominate the global excipients landscape, with a 39.8 percent market share. The Asia-Pacific region is the fastest-growing segment with a substantial 30.4 percent market share, driven by increasing investments in pharmaceutical manufacturing, growing demand for cost-effective drugs, and rising healthcare expenditure across developing economies.Major excipient providers include BASF, Merck KGaA owned MilliporeSigma, Gangwal Healthcare, DuPont, Evonik, Seqens, Actylis, SPI Pharma, PMC Isochem, Croda International, Pfanstiehl, Kewpie Corporation, Boai NKY Pharmaceuticals, ICE Pharma, Roquette, Nanjing Well Pharmaceutical, Minakem, Ashland Global, Anhui Ribobay Pharmaceutical and Nippon Fine Chemical. View Our Dashboard on Major Excipient Companies in 2025 (Free Excel Available)Roquette restructures after buying IFF Pharma; Colorcon partners ASHA CelluloseIn May, Roquette completed its acquisition of IFF Pharma Solutions. Valued at up to US$ 2.85 billion in enterprise value, this transaction represents a major consolidation in the pharmaceutical excipients market. The acquisition significantly enhances Roquette’s ability to deliver high-value drug delivery solutions to pharmaceutical customers worldwide. Roquette announced a comprehensive, new organizational structure following the acquisition, indicating the company’s commitment to integrate IFF Pharma Solutions’ capabilities seamlessly into its existing operations. This consolidation creates a more robust platform for addressing the growing demand for specialized excipients in complex drug formulations, particularly as the industry moves towards more personalized approaches to medicines.So far, the year has also witnessed some strategic alliances, such as Colorcon’s partnership with ASHA Cellulose. As part of the deal, Colorcon will become the exclusive representative for two ASHA products — ASHACEL and ASHAKOTE — throughout Europe, the Middle East, Africa, Northeast Asia and Southeast Asia.Brenntag Specialties has announced an exclusive distribution agreement with MEGGLE Excipients to expand market reach. This collaboration makes available a broad portfolio of over 30 high-quality lactose-based excipients for various applications in the pharmaceutical industries across the Netherlands, Belgium, Norway, Finland, and Sweden.The portfolio’s versatility offers optimal solutions for a wide range of pharmaceutical applications, including tableting through both granulation and direct compression, powder preparations, and dry powder inhalation. View Our Dashboard on Major Excipient Companies in 2025 (Free Excel Available)WHO, FDA drive new standards with GMP guidelines; Pfanstiehl launches injectable-grade glycineIn March, the World Health Organization had put out a publication titled “Good Manufacturing Practices for Excipients used in Pharmaceutical Products.” WHO’s excipient GMP guideline emphasizes modern quality management principles, comprehensive risk assessment protocols, and supplier qualification procedures for excipients across all stages of production, storage, and distribution.Meanwhile, the US Food and Drug Administration (FDA) has proposed amendments to the Food, Drug, and Cosmetic Act as part of its FY 2025 legislative proposals, specifically targeting supply chain transparency for high-risk excipients. The FDA proposal would require certain excipients designated as high-risk to carry labeling that identifies the original manufacturer’s name and address. This initiative addresses what FDA has identified as a lack of transparency in excipient supply chains.In April, IFF Pharma Solutions launched Low Nitrite METHOCEL hydroxypropyl methylcellulose (HPMC). This innovative product is specifically designed to reduce the risk of nitrosamine formation in finished pharmaceutical dosages, addressing one of the most pressing concerns in contemporary pharmaceutical manufacturing.Pfanstiehl, a global leader in high-purity excipient manufacturing, announced the launch of its High Purity Low Endotoxin Low Metals (HPLE-LM) injectable-grade glycine. This multi-compendial glycine is specifically engineered for use in biologics, vaccines, and the downstream purification of monoclonal antibodies (mAbs). Manufactured under ICH-Q7 cGMP regulations at Pfanstiehl’s advanced facility in Waukegan, Illinois, the product meets stringent global pharmacopeial standards. View Our Dashboard on Major Excipient Companies in 2025 (Free Excel Available)Shin-Etsu Chemical invests in Japan, Germany to expand cellulose productionIn March, Shin-Etsu Chemical announced investments in pharmaceutical cellulose business operations in Japan and Europe, thereby showing significant commitment to market expansion. The company is making substantial investments at two key bases: the subsidiary SE Tylose GmbH in Germany, and the Naoetsu Plant in Joetsu, Japan. In Germany, a new production facility for the pharmaceutical excipient L-HPC will be built adjacent to the existing facility, creating a dual base with the Naoetsu Plant. The excipients market in 2025 has seen innovation in functional applications. Research on BENEO’s Palatinose as a bedtime drink shows that it improves aspects of sleep and represents an innovative approach to excipient functionality. Palatinose is a naturally sourced, smart carbohydrate that provides full carbohydrate energy in a more balanced way, thanks to its low-glycemic profile.Gangwal Healthcare, with its EXCiPACT-certified GMP facilities and a robust portfolio of co-processed excipients like ProBlend, Starlose, and Microlose, is actively contributing to the pharmaceutical industry’s demand for functional excipients. The company also offers cellulose-based excipients such as Solvostar (Sodium Starch Glycolate) and Sallyso (Croscarmellose Sodium), designed to improve tablet disintegration and drug release profiles in oral solid dosage forms.Evonik announced a partnership with South Korea–based CDMO ST Pharm to expand its RNA and nucleic acid delivery services. This collaboration enables Evonik to integrate customized nucleic acids from ST Pharm seamlessly with its lipid and lipid nanoparticle (LNP) development and fill-and-finish services. This streamlined approach means that pharmaceutical companies can reduce complexity and increase speed-to-market for nucleic acid therapeutics. View Our Dashboard on Major Excipient Companies in 2025 (Free Excel Available)Our viewThe pharmaceutical excipients market in 2025 is being shaped by several key trends including the development of multifunctional excipients that can simultaneously improve solubility, bioavailability, and control drug release in increasingly complex formulations.Moreover, the expanding generic medicines market is creating demand for cost-effective, versatile excipients. The growing importance of biologics and biosimilars is driving innovation in specialized excipients designed to maintain the stability and efficacy of these complex therapeutic products throughout their lifecycle. And nanotechnology continues to enable advanced nano-excipients for enhanced drug delivery and efficacy.In addition to these trends, we also notice a shift towards natural and plant-based excipients that is driven by sustainability concerns and potential biocompatibility benefits. 
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    29 May 2025
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    Excipient Market Overview: Roquette, Seqens, Evonik make strategic moves; new guidelines deal with contamination

    Excipient Market Overview: Roquette, Seqens, Evonik make strategic moves; new guidelines deal with contamination

    The pharmaceutical industry has long recognized the critical role excipients or inactive ingredients play in drug formulation and delivery. Excipients can comprise up to 90 percent of a medicine's total ingredients and serve crucial functions as binders, disintegrants, coatings, preservatives, colors, and flavorings. According to recent market research, the pharmaceutical excipients market was valued at US$ 9.27 billion in 2023. It is growing at a compound annual growth rate (CAGR) of 7.03 percent and is projected to reach US$ 18.48 billion by 2032. The main factors driving market growth is an increased demand for multifunctional excipients, coupled with the expanding use of generic medications. The development in the biologics sector and advancements in nanotechnology are also contributing significantly to market growth. Major excipient providers include BASF, Evonik, Merck KGaA owned MilliporeSigma, Gangwal Healthcare, Roquette Frères, DuPont, Croda International, Seqens, Boai NKY Pharmaceuticals, PMC Isochem, Minakem, Kewpie Corporation, Ashland Global, SPI Pharma, Pfanstiehl, Nanjing Well Pharmaceutical, ICE Pharma, Anhui Ribobay Pharmaceutical and Nippon Fine Chemical.  View Our Dashboard on Major Excipient Companies in 2024 (Free Excel Available) WHO, India’s CDSCO tighten regulations; new GMP guidelines implemented to curb contamination Last year, the World Health Organization (WHO) issued a health alert linking at least 300 child deaths in the Gambia, Uzbekistan, and Indonesia to the ingestion of contaminated cough syrups containing unacceptable levels of diethylene glycol (DEG) and ethylene glycol (EG). In response to the tragic events, the WHO released two draft appendices to its guideline on good manufacturing practices (GMPs) for excipients this year. Manufacturers are now required to use suitable risk assessment tools to identify and mitigate potential hazards.  Since India-made cough syrups had been linked to the deaths, India’s drug regulator — Central Drugs Standard Control Organization (CDSCO) — took steps to prevent contamination, and advised drugmakers to only use pharmaceutical-grade excipients from approved sources. Furthermore, the Indian Health Ministry proposed amendments to the Drugs and Cosmetics Rules, 1945 to include details of excipients on drug labels. While listing all excipients on every strip of medicine may be challenging, the ministry suggested mentioning those causing hypersensitivity on the label. Applicants now mandatorily need to submit evidence of stability and safety of excipients. These regulatory developments have significant implications for excipient manufacturers and pharmaceutical companies worldwide. Leading pharmaceutical excipient firms like Gangwal Healthcare, Sigachi Industries, and Nitika Pharmaceuticals are well-positioned to meet these heightened quality and safety standards, given their long-standing commitment to producing high-quality, compliant excipients.  View Our Dashboard on Major Excipient Companies in 2024 (Free Excel Available)   Roquette buys IFF’s pharma unit for US$ 2.85 bn; Evonik opens new spray-drying facility in Darmstadt In a significant industry move, France-based Roquette entered into an agreement to acquire IFF's pharma solutions business in a deal valued at US$ 2.85 billion. This acquisition is set to rebalance family-owned Roquette’s portfolio around health and nutrition. The deal is expected to accelerate Roquette’s growth and significantly strengthen its presence in the excipients market. Evonik has opened a new facility for drying aqueous dispersions of its Eudragit polymers at its site in Darmstadt, Germany. The facility will help Evonik meet increasing demand from drugmakers for its oral drug delivery solutions. The plant uses green energy solutions. The company has also partnered University of Mainz to commercialize a new class of polyethylene glycols (PEG) lipids for nucleic acid delivery. Evonik’s Health Care business has been growing its nucleic acid drug and vaccine delivery portfolio.  Germany’s Johannes Gutenberg University of Mainz was the first to develop randomized polyethylene glycols (rPEGs). This collaboration aims to expand Evonik’s toolbox of technologies for nucleic acid-based medicines, offering an improved immunogenicity profile for lipid nanoparticle carriers used in mRNA vaccines and therapeutics. Asahi Kasei made significant strides in addressing a pressing industry concern that emerged in 2018 when potentially carcinogenic nitrosamine impurities were detected in several pharmaceuticals. Guided by regional authorities, such as the European Medicines Agency and the US Food and Drug Administration, the pharmaceutical industry has been carrying out extensive assessments and research to identify the cause of these impurities. In response to this challenge, Asahi Kasei developed its Ceolus microcrystalline cellulose with extremely low nitrite levels. The Japanese company achieved nitrite concentrations of 0.1 micrograms per gram or less, which is equivalent to 0.1 parts per million (ppm). The company also started full commercial operation of its second manufacturing facility for Ceolus in Japan, enhancing supply capacity and stability. JRS Pharma and Gujarat Microwax opened a state-of-the-art cotton-based croscarmellose sodium plant in Mehsana, Gujarat (India). This facility aims to produce high-quality excipients that meet global standards, potentially reducing India's dependency on imports and boosting its presence in the global excipient market. The Indian excipient industry accounts for less than 1 percent of the global market share.  View Our Dashboard on Major Excipient Companies in 2024 (Free Excel Available)   Seqens to advance innovative polymer; biologics, personalized medicine create demand for specialized excipients Recent industry collaborations highlight the ongoing innovation in novel excipients. France’s Seqens, with over 20 years of polymer development experience, was chosen by Pleryon Therapeutics to advance its leading osteoarthritis candidate – an innovative GMP polymer. This collaboration leverages Seqens’ newly expanded and modernized cGMP plant in Aramon, France, demonstrating the industry’s commitment to investing in advanced manufacturing capabilities for novel excipients.  The rise of biologics and personalized medicine has created a demand for specialized excipients capable of stabilizing complex molecules and enabling targeted drug delivery. Roquette’s launch of Lycagel Flex, a hydroxypropyl pemix for nutraceutical and pharmaceutical softgel capsules, exemplifies this trend. Built on Roquette’s market-first Lycagel pea starch technology, this plant-based alternative to gelatin offers manufacturers the flexibility to customize formulations for a range of production and end-user needs. The innovative pea starch foundation also underscores the industry’s move towards sustainable bio-based excipients. The trend towards patient-centric drug development has also influenced excipient innovation. Excipients that can improve palatability, ease of swallowing, or enable novel dosage forms (such as orally disintegrating tablets) are in high demand. For example, IFF brought a super disintegrant Ac-Di-Sol, that supports faster disintegration and drug dissolution in oral disintegrating tablets, improving patient experience.  View Our Dashboard on Major Excipient Companies in 2024 (Free Excel Available)   Our view The heightened regulatory scrutiny on excipients due to product contamination incidents has created a high risk perception and uncertainty around the regulatory acceptance of novel excipients. That said, novel excipients are central to the development of new drug modalities and therapies. Going forward, sustainability will also become an increasingly important factor in excipient selection and development. As the industry innovates towards biologics, personalized therapies, and patient-centric formulations, the role of high-quality, multifunctional excipients will only grow more vital in ensuring drug stability, bioavailability, and patient compliance. Companies that can navigate the complex regulatory landscape, invest in R&D, and offer high-quality, multifunctional excipients will be well-positioned to succeed in this evolving market.   
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    Enhancing Patient Experience UltraBurst™The Ultimate ODT Solution
    Enhancing Patient Experience UltraBurst™The Ultimate ODT Solution

    03 Feb 2025

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    https://www.spipharma.com/en/insights-and-events/news-blog/enhancing-patient-experience-with-ultraburst-the-ultimate-odt-solution/

    PRESS RELEASE
    03 Feb 2025
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    Beyond Pharma: SPI Pharma’s Impact Across Industries
    Beyond Pharma: SPI Pharma’s Impact Across Industries

    11 Dec 2024

    // PRESS RELEASE

    https://www.spipharma.com/en/insights-and-events/news-blog/beyond-pharma-spi-pharma-s-impact-across-industries/

    PRESS RELEASE
    11 Dec 2024
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    SPI Pharma & Inimmune to Develop &Commercialize Vaccine Adjuvant
    SPI Pharma & Inimmune to Develop &Commercialize Vaccine Adjuvant

    17 Jul 2024

    // PR NEWSWIRE

    https://www.prnewswire.com/news-releases/spi-pharma-inc-and-inimmune-corp-partner-to-develop-and-commercialize-innovative-vaccine-adjuvant-systems-302198093.html

    PR NEWSWIRE
    17 Jul 2024
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    Embracing Patient-Centric Formulations for a Healthier Tomorrow
    Embracing Patient-Centric Formulations for a Healthier Tomorrow

    08 Jan 2024

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    https://www.spipharma.com/en/insights-and-events/news-blog/embracing-patient-centric-formulations-for-a-healthier-tomorrow/

    PRESS RELEASE
    08 Jan 2024
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    Offering broader access to sustainable pharma-grade saponin adjuvants
    Offering broader access to sustainable pharma-grade saponin adjuvants

    13 Oct 2023

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    https://www.spipharma.com/en/insights-and-events/news-blog/offering-broader-access-to-sustainable-and-scalable-pharma-grade-saponin-adjuvants/

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    13 Oct 2023
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    SPI Pharma In Grand Haven Receives Excipact Gmp Certification
    SPI Pharma In Grand Haven Receives Excipact Gmp Certification

    10 Jul 2023

    // EXCIPACT

    https://www.excipact.org/news-reader/spi-pharma-in-grand-haven-usa-receives-excipact-gmp-certification-as-pharmaceutical-excipient-supplier.html

    EXCIPACT
    10 Jul 2023
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    Excipients

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    GMP Certified

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    Type : GMP Certificates

    Number : 24MPP022HFR...

    EudraGMDP Key : 172512

    Country : France

    Issue Date : 2024-04-26

    Post Code : 13240

    NCA Ref : 417890910000...

    City : Septemes-Les-Vallons

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    GMP Certified

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    Type : GMP Certificates

    Number : 2023_HPF_FR...

    EudraGMDP Key : 165091

    Country : France

    Issue Date : 2023-04-14

    Post Code :

    NCA Ref : 417890910000...

    City : Septemes-Les-Vallons

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    GMP Certified

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    Type : GMP Certificates

    Number : 21MPP005HFR...

    EudraGMDP Key : 126742

    Country : France

    Issue Date : 2021-04-29

    Post Code : 13240

    NCA Ref : 417890910000...

    City : SEPTEMES LES VALLONS

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    GMP Certified

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    Type : GMP Certificates

    Number : 17MPP082HFR...

    EudraGMDP Key : 50846

    Country : France

    Issue Date : 2018-11-14

    Post Code : 13240

    NCA Ref : 417890910000...

    City : SEPTEMES LES VALLONS

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    GMP Certified

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    SPI Pharma

    Type : GMP Certificates

    Number : 12MPP071HFR...

    EudraGMDP Key : 38422

    Country : France

    Issue Date : 2016-11-02

    Post Code : 13240

    NCA Ref : 417890910000...

    City : SEPTEMES LES VALLONS

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    GMP Certified

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    World Vaccine Congress
    Attending

    SPI Pharma

    Type : GMP Certificates

    Number : HMP/FR/44/2...

    EudraGMDP Key : 31929

    Country : France

    Issue Date : 2015-11-04

    Post Code : 13240

    NCA Ref : 417890910000...

    City : SEPTEMES LES VALLONS

    SPI Pharma

    Product
    Web Link

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    07

    GMP Certified

    EU
    arrow
    World Vaccine Congress
    Attending

    SPI Pharma

    Type : GMP Certificates

    Number : HMP/FR/39/2...

    EudraGMDP Key : 21771

    Country : France

    Issue Date : 2013-05-15

    Post Code : 13240

    NCA Ref : 417 890 910 ...

    City : SEPTEMES LES VALLONS

    SPI Pharma

    Product
    Web Link

    Stock Recap
    #PipelineProspector

    Data Compilation
    #PharmaFlow

    08

    GMP Certified

    EU
    arrow
    World Vaccine Congress
    Attending

    SPI Pharma

    Type : GMP Certificates

    Number : HMP/FR/54/2...

    EudraGMDP Key : 10042

    Country : France

    Issue Date : 2011-02-16

    Post Code : 13240

    NCA Ref : 417 890 910 ...

    City : SEPTEMES LES VALLONS

    SPI Pharma

    Product
    Web Link

    Stock Recap
    #PipelineProspector

    Data Compilation
    #PharmaFlow

    09

    GMP Certified

    EU
    arrow
    World Vaccine Congress
    Attending

    SPI Pharma

    Type : GMP Certificates

    Number : VMP/FR/3/20...

    EudraGMDP Key : 10036

    Country : France

    Issue Date : 2011-02-16

    Post Code : 13240

    NCA Ref : 417 890 910 ...

    City : SEPTEMES LES VALLONS

    SPI Pharma

    Product
    Web Link

    Stock Recap
    #PipelineProspector

    Data Compilation
    #PharmaFlow

    10

    GMP Certified

    EU
    arrow
    World Vaccine Congress
    Attending

    SPI Pharma

    Type : GMP Certificates

    Number : 2008/HMP/PT...

    EudraGMDP Key : 4562

    Country : U.S.A

    Issue Date : 2008-07-22

    Post Code : 19958

    NCA Ref : 417 890 910 ...

    City : LEWES

    SPI Pharma

    Product
    Web Link

    Stock Recap
    #PipelineProspector

    Data Compilation
    #PharmaFlow

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