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2D Structure
Also known as: Tenfidil, Thefanil, Thenfadil, 91-79-2, Dethylandiamine, Tenildiamina
Molecular Formula
C14H19N3S
Molecular Weight
261.39  g/mol
InChI Key
RCGYDFVCAAKKNG-UHFFFAOYSA-N
FDA UNII
E4U52363JE

structure
1 2D Structure

2D Structure

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-3-ylmethyl)ethane-1,2-diamine
2.1.2 InChI
InChI=1S/C14H19N3S/c1-16(2)8-9-17(11-13-6-10-18-12-13)14-5-3-4-7-15-14/h3-7,10,12H,8-9,11H2,1-2H3
2.1.3 InChI Key
RCGYDFVCAAKKNG-UHFFFAOYSA-N
2.2 Other Identifiers
2.2.1 UNII
E4U52363JE
2.3 Synonyms
2.3.1 MeSH Synonyms

1. 2-((2-dimethylaminoethyl)-3-thenylamino)pyridine

2.3.2 Depositor-Supplied Synonyms

1. Tenfidil

2. Thefanil

3. Thenfadil

4. 91-79-2

5. Dethylandiamine

6. Tenildiamina

7. Thenyldiaminum

8. Nci-c60640

9. Win-2848

10. 2-((2-dimethylaminoethyl)-3-thenylamino)pyridine

11. Dtxsid0021335

12. 2-((2-(dimethylamino)ethyl)-3-thenylamino)pyridine

13. N-(2-dimethylaminoethyl)-n-2-pyridyl-3-thenylamine

14. 1,2-ethanediamine, N,n-dimethyl-n'-2-pyridinyl-n'-(3-thienylmethyl)-

15. E4u52363je

16. Pyridine, 2-((2-(dimethylamino)ethyl)-3-thenylamino)-

17. Dtxcid601335

18. N-(alpha-pyridyl)-n-(beta-thenyl)-n',n'-dimethylethylenediamine

19. N,n-dimethyl-n'-(alpha-pyridyl)-n'-(3-methylthienyl)ethylenediamine

20. N,n-dimethyl-n'-2-pyridinyl-n'-(3-thienylmethyl)-1,2-ethanediamine

21. 2-[(2-dimethylaminoethyl)-3-thenylamino]pyridine

22. Pyridine, 2-[[2-(dimethylamino)ethyl]-3-thenylamino]-

23. Refchem:189171

24. 202-098-2

25. Thenyldiamine (pharmaceutical)

26. N,n-dimethyl-n'-pyridin-2-yl-n'-(thiophen-3-ylmethyl)ethane-1,2-diamine

27. Thenyldiamine [inn:ban]

28. Tenildiamina [inn-spanish]

29. Thenyldiaminum [inn-latin]

30. Hsdb 5190

31. Einecs 202-098-2

32. Brn 0221267

33. Dethlandiamine

34. Unii-e4u52363je

35. Thenyldiamine [mi]

36. Thenyldiamine [inn]

37. Thenyldiamine [hsdb]

38. Schembl28948

39. 4-22-00-03953 (beilstein Handbook Reference)

40. Win 2848

41. Thenyldiamine [who-dd]

42. Chembl2107485

43. Chebi:186232

44. Tox21_113737

45. N,n-dimethyl-n'-pyridin-2-yl-n'-(3-thienylmethyl)ethane-1,2-diamine

46. N-[2-(dimethylamino)ethyl]-n-[(thiophen-3-yl)methyl]pyridin-2-amine

47. Cas-91-79-2

48. Ncgc00253602-01

49. Ns00005291

50. En300-18553886

51. Q7781412

52. 1,2-ethanediamine,n1,n1-dimethyl-n2-2-pyridinyl-n2-(3-thienylmethyl)-

53. N-(.alpha.-pyridyl)-n-(.beta.-thenyl)-n',n'-dimethylethylenediamine

2.4 Create Date
2005-03-27
3 Chemical and Physical Properties
Molecular Weight 261.39 g/mol
Molecular Formula C14H19N3S
XLogP33
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count4
Rotatable Bond Count6
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area47.6
Heavy Atom Count18
Formal Charge0
Complexity235
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Drug and Medication Information
4.1 Therapeutic Uses

Nasal Decongestants; Histamine H1 Antagonists

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)


THESE INCLUDE SOME OF THE MOST SPECIFIC AND ACTIVE H1 ANTAGONISTS. ALTHOUGH THEIR CENTRAL EFFECTS ARE RELATIVELY FEEBLE AND OF NO THERAPEUTIC VALUE, SOMNOLENCE OCCURS. /ETHYLENEDIAMINES/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 627


ANTIHISTAMINIC AGENT (AS HYDROCHLORIDE)

SRI


ANTIHISTAMINIC AGENT; PRC: FORMERLY USED AS A SEDATIVE /HYDROCHLORIDE/

The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 1195