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ACTIVE PHARMA INGREDIENTS

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Synopsis

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Chemistry

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Also known as: Tenfidil, Thefanil, Thenfadil, 91-79-2, Dethylandiamine, Tenildiamina

Molecular Formula

C₁₄H₁₉N₃S

Molecular Weight

261.39 g/mol

InChI Key

RCGYDFVCAAKKNG-UHFFFAOYSA-N

FDA UNII

E4U52363JE

structure

1 2D Structure

Thenyldiamine

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

N,N-dimethyl-N'-pyridin-2-yl-N'-(thiophen-3-ylmethyl)ethane-1,2-diamine

2.1.2 InChI

InChI=1S/C14H19N3S/c1-16(2)8-9-17(11-13-6-10-18-12-13)14-5-3-4-7-15-14/h3-7,10,12H,8-9,11H2,1-2H3

2.1.3 InChI Key

RCGYDFVCAAKKNG-UHFFFAOYSA-N

2.2 Other Identifiers

2.2.1 UNII

E4U52363JE

2.3 Synonyms

2.3.1 MeSH Synonyms

1. 2-((2-dimethylaminoethyl)-3-thenylamino)pyridine

2.3.2 Depositor-Supplied Synonyms

1. Tenfidil

2. Thefanil

3. Thenfadil

4. 91-79-2

5. Dethylandiamine

6. Tenildiamina

7. Thenyldiaminum

8. Nci-c60640

9. Win-2848

10. 2-((2-dimethylaminoethyl)-3-thenylamino)pyridine

11. Dtxsid0021335

12. 2-((2-(dimethylamino)ethyl)-3-thenylamino)pyridine

13. N-(2-dimethylaminoethyl)-n-2-pyridyl-3-thenylamine

14. 1,2-ethanediamine, N,n-dimethyl-n'-2-pyridinyl-n'-(3-thienylmethyl)-

15. E4u52363je

16. Pyridine, 2-((2-(dimethylamino)ethyl)-3-thenylamino)-

17. Dtxcid601335

18. N-(alpha-pyridyl)-n-(beta-thenyl)-n',n'-dimethylethylenediamine

19. N,n-dimethyl-n'-(alpha-pyridyl)-n'-(3-methylthienyl)ethylenediamine

20. N,n-dimethyl-n'-2-pyridinyl-n'-(3-thienylmethyl)-1,2-ethanediamine

21. 2-[(2-dimethylaminoethyl)-3-thenylamino]pyridine

22. Pyridine, 2-[[2-(dimethylamino)ethyl]-3-thenylamino]-

23. Refchem:189171

24. 202-098-2

25. Thenyldiamine (pharmaceutical)

26. N,n-dimethyl-n'-pyridin-2-yl-n'-(thiophen-3-ylmethyl)ethane-1,2-diamine

27. Thenyldiamine [inn:ban]

28. Tenildiamina [inn-spanish]

29. Thenyldiaminum [inn-latin]

30. Hsdb 5190

31. Einecs 202-098-2

32. Brn 0221267

33. Dethlandiamine

34. Unii-e4u52363je

35. Thenyldiamine [mi]

36. Thenyldiamine [inn]

37. Thenyldiamine [hsdb]

38. Schembl28948

39. 4-22-00-03953 (beilstein Handbook Reference)

40. Win 2848

41. Thenyldiamine [who-dd]

42. Chembl2107485

43. Chebi:186232

44. Tox21_113737

45. N,n-dimethyl-n'-pyridin-2-yl-n'-(3-thienylmethyl)ethane-1,2-diamine

46. N-[2-(dimethylamino)ethyl]-n-[(thiophen-3-yl)methyl]pyridin-2-amine

47. Cas-91-79-2

48. Ncgc00253602-01

49. Ns00005291

50. En300-18553886

51. Q7781412

52. 1,2-ethanediamine,n1,n1-dimethyl-n2-2-pyridinyl-n2-(3-thienylmethyl)-

53. N-(.alpha.-pyridyl)-n-(.beta.-thenyl)-n',n'-dimethylethylenediamine

2.4 Create Date

2005-03-27

3 Chemical and Physical Properties

Molecular Formula	C₁₄H₁₉N₃S
Molecular Weight	261.39 g/mol
XLogP3	3
Hydrogen Bond Donor Count	0
Hydrogen Bond Acceptor Count	4
Rotatable Bond Count	6
Exact Mass	Da
Monoisotopic Mass	Da
Topological Polar Surface Area	47.6
Heavy Atom Count	18
Formal Charge	0
Complexity	235
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	1

4 Drug and Medication Information

4.1 Therapeutic Uses

Nasal Decongestants; Histamine H1 Antagonists

National Library of Medicine's Medical Subject Headings online file (MeSH, 1999)

THESE INCLUDE SOME OF THE MOST SPECIFIC AND ACTIVE H1 ANTAGONISTS. ALTHOUGH THEIR CENTRAL EFFECTS ARE RELATIVELY FEEBLE AND OF NO THERAPEUTIC VALUE, SOMNOLENCE OCCURS. /ETHYLENEDIAMINES/

Gilman, A. G., L. S. Goodman, and A. Gilman. (eds.). Goodman and Gilman's The Pharmacological Basis of Therapeutics. 6th ed. New York: Macmillan Publishing Co., Inc. 1980., p. 627

ANTIHISTAMINIC AGENT (AS HYDROCHLORIDE)

SRI

ANTIHISTAMINIC AGENT; PRC: FORMERLY USED AS A SEDATIVE /HYDROCHLORIDE/

The Merck Index. 9th ed. Rahway, New Jersey: Merck & Co., Inc., 1976., p. 1195

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