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    Selnoflast

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    2D Structure
    Also known as: 2260969-36-4, Selnoflast [inn], T23rpa8wa2, Rg6418, Ro7486967, Ro-7486967
    Molecular Formula
    C20H29N3O3S
    Molecular Weight
    391.5  g/mol
    InChI Key
    OHIFQOUPTWBQLE-UHFFFAOYSA-N
    FDA UNII
    T23RPA8WA2
    Selnoflast is a small molecule drug. The usage of the INN stem '-noflast' in the name indicates that Selnoflast is a inflammasome protein NLRP3 inhibitor. Selnoflast is under investigation in clinical trial NCT05924243 (A Study to Investigate The Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of RO7486967 in Participants With Early Idiopathic Parkinson's Disease.). Selnoflast has a monoisotopic molecular weight of 391.19 Da.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    1-(1-ethylpiperidin-4-yl)sulfonyl-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea
    2.1.2 InChI
    InChI=1S/C20H29N3O3S/c1-2-23-11-9-16(10-12-23)27(25,26)22-20(24)21-19-17-7-3-5-14(17)13-15-6-4-8-18(15)19/h13,16H,2-12H2,1H3,(H2,21,22,24)
    2.1.3 InChI Key
    OHIFQOUPTWBQLE-UHFFFAOYSA-N
    2.2 Other Identifiers
    2.2.1 UNII
    T23RPA8WA2
    2.3 Synonyms
    2.3.1 Depositor-Supplied Synonyms

    1. 2260969-36-4

    2. Selnoflast [inn]

    3. T23rpa8wa2

    4. Rg6418

    5. Ro7486967

    6. Ro-7486967

    7. Rg-6418

    8. Example 6 [wo2019008025a1]

    9. 1-(1-ethylpiperidin-4-yl)sulfonyl-3-(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)urea

    10. 1-ethyl-n-(((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino)carbonyl)-4-piperidinesulfonamide

    11. 4-piperidinesulfonamide, 1-ethyl-n-(((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino)carbonyl)-

    12. Example 6 (wo2019008025a1)

    13. Refchem:182333

    14. Selnoflast [usan]

    15. Selnoflast [usan:inn]

    16. Unii-t23rpa8wa2

    17. Who 11687

    18. 1-ethyl-n-((1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl)piperidine-4-sulfonamide

    19. 1-ethyl-n-[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)carbamoyl]piperidine-4-sulfonamide

    20. Selnoflast (usan/inn)

    21. Orb1688251

    22. Chembl5095423

    23. Schembl20634304

    24. Gtpl12173

    25. Bdbm733146

    26. Glxc-27711

    27. Ex-a9807

    28. Mfcd34579587

    29. Us20250115591, Example 6

    30. Da-57784

    31. Ms-26540

    32. Sy347075

    33. Hy-132831

    34. Cs-0204138

    35. D12422

    36. G18544

    37. 4-piperidinesulfonamide,1-ethyl-n-[[(1,2,3,5,6,7-hexahydro-s-indacen-4-yl)amino]carbonyl]-

    2.4 Create Date
    2019-03-16
    3 Chemical and Physical Properties
    Molecular Weight 391.5 g/mol
    Molecular Formula C20H29N3O3S
    XLogP33.7
    Hydrogen Bond Donor Count2
    Hydrogen Bond Acceptor Count4
    Rotatable Bond Count4
    Exact Mass Da
    Monoisotopic Mass Da
    Topological Polar Surface Area86.9
    Heavy Atom Count27
    Formal Charge0
    Complexity619
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
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