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Technical details about Morphine Sulfate, learn more about the structure, uses, toxicity, action, side effects and more

Morphine Sulfate

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

25 Suppliers, 13 USDMF, 6 CEP/COS, 4 KDMF, 13 NDC API, 14 Listed Suppliers

DEVELOPMENTS

1 Drug(s) in Development

1 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Exports, FDF Imports

DOSSIERs // Finished Dosage Forms

586 Dossiers, 223 FDA Orange Book, 116 Europe, 47 Canada, 108 Australia, 19 South Africa, 73 Listed Dossiers

DRUG PRODUCT COMPOSITION

TABLET, EXTENDED RELEASE;ORAL - 100MG, TABLET, EXTENDED RELEASE;ORAL - 15MG, TABLET, EXTENDED RELEASE;ORAL - 200MG, TABLET, EXTENDED RELEASE;ORAL - 30MG, TABLET, EXTENDED RELEASE;ORAL - 60MG, INJECTABLE;INJECTION - 1MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, INJECTABLE;INJECTION - 5MG/ML **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, SOLUTION;INTRAMUSCULAR - 10MG/0.7ML (10MG/0.7ML), INJECTABLE;INJECTION - 10MG/ML, INJECTABLE;INJECTION - 15MG/ML, INJECTABLE;INJECTION - 2MG/ML, INJECTABLE;INJECTION - 4MG/ML, INJECTABLE;INJECTION - 50MG/ML, INJECTABLE;INJECTION - 8MG/ML, CAPSULE, EXTENDED RELEASE;ORAL - 100MG, CAPSULE, EXTENDED RELEASE;ORAL - 10MG, CAPSULE, EXTENDED RELEASE;ORAL - 130MG, CAPSULE, EXTENDED RELEASE;ORAL - 150MG, CAPSULE, EXTENDED RELEASE;ORAL - 200MG, CAPSULE, EXTENDED RELEASE;ORAL - 20MG, CAPSULE, EXTENDED RELEASE;ORAL - 30MG, CAPSULE, EXTENDED RELEASE;ORAL - 40MG, CAPSULE, EXTENDED RELEASE;ORAL - 50MG, CAPSULE, EXTENDED RELEASE;ORAL - 60MG, CAPSULE, EXTENDED RELEASE;ORAL - 70MG, CAPSULE, EXTENDED RELEASE;ORAL - 80MG, TABLET, EXTENDED RELEASE;ORAL - 100MG, TABLET, EXTENDED RELEASE;ORAL - 15MG, TABLET, EXTENDED RELEASE;ORAL - 30MG, TABLET, EXTENDED RELEASE;ORAL - 60MG, TABLET, EXTENDED RELEASE;ORAL - 15MG, TABLET, EXTENDED RELEASE;ORAL - 30MG, TABLET, EXTENDED RELEASE;ORAL - 60MG, SOLUTION;ORAL - 100MG/5ML, SOLUTION;ORAL - 10MG/5ML, SOLUTION;ORAL - 20MG/5ML, TABLET;ORAL - 15MG, TABLET;ORAL - 30MG, CAPSULE, EXTENDED RELEASE;ORAL - 100MG;4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 20MG;0.8MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 30MG;1.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 50MG;2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 60MG;2.4MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**, CAPSULE, EXTENDED RELEASE;ORAL - 80MG;3.2MG **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

RELATED EXCIPIENT COMPANIES

Suppliers, 39 Kerry, 36 BASF, 27 Roquette, 18 Microlex e.U, 17 SPI Pharma, 17 Corel Pharma Chem, 16 Ideal Cures Pvt Ltd, 15 Actylis, 15 Seppic, 12 Gangwal Chemicals, 11 Gangwal Healthcare, 10 Sigachi Industries, 10 Nanjing Well Pharmaceutical, 7 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 6 Lonza Capsugel, 6 DKSH, 6 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 5 DFE Pharma, 4 Kima Chemical, 4 ACG Worldwide, 4 Rochem International Inc, 4 Finar, 3 The Dow Chemical Company, 3 Evonik, 3 Ingredion Pharma Solutions, 3 Boai NKY Pharmaceuticals Ltd, 2 Nomisma Healthcare, 2 Ulanqab Kema New Material, 2 Vasa Pharmachem, 2 Clariant, 2 Shijiazhuang Huaxu Pharmaceutical, 2 Pharmatrans-Sanaq, 2 Qualicaps, 2 Pharm-RX Chemical, 2 Prachin Chemical, 2 Pfanstiehl, 2 Seqens, 1 Avesta Pharma, 1 Zhejiang Huakang Pharmaceutical, 1 Jai Radhe Sales, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Aeon Procare, 1 Shanghai Welltone Material Technology Co., Ltd, 1 Bioplus Life Sciences, 1 Alcedo Pharmachem, 1 Nanjing Bold Chemical, 1 Vertellus

EXCIPIENTS BY APPLICATIONS

93 Fillers, Diluents & Binders, 77 Coating Systems & Additives, 54 Controlled & Modified Release, 39 Direct Compression, 32 Solubilizers, 31 Parenteral, 28 Topical, 28 Thickeners and Stabilizers, 27 Taste Masking, 26 Granulation, 25 Film Formers & Plasticizers, 21 Lubricants & Glidants, 17 Co-Processed Excipients, 16 Chewable & Orodispersible Aids, 15 Disintegrants & Superdisintegrants, 9 API Stability Enhancers, 9 Empty Capsules, 8 Emulsifying Agents, 4 Vegetarian Capsules, 4 Surfactant & Foaming Agents, 4 Rheology Modifiers, 2 Coloring Agents, 1 Soft Gelatin

GLOBAL SALES INFORMATION

56 US Medicaid Prescriptions, 133 Finished Drug Prices

MARKET PLACE

14 APIs, 19 DOSSIERS // FDF

PATENTS

88 US Patents, 4 US Exclusivities, 26 Health Canada Patents

ANALYTICAL SOLUTION(s)

2 EDQM Standards, 4 USP Standards, 7 Other Ref. Standards

DIGITAL CONTENT

4 Data Compilation & Company Tracker #PharmaFlow, 117 News

1. Also known as: Morphine sulfate, Schembl29317, Morphinesulfatenarcoticanalgesic

Molecular Formula

C₁₇H₂₁NO₇S

Molecular Weight

383.4 g/mol

InChI Key

OOZBZVAQKFGLOL-VYKNHSEDSA-N

The principal alkaloid in opium and the prototype opiate analgesic and narcotic. Morphine has widespread effects in the central nervous system and on smooth muscle.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(4R,4aR,7S,7aR,12bS)-3-methyl-2,4,4a,7,7a,13-hexahydro-1H-4,12-methanobenzofuro[3,2-e]isoquinoline-7,9-diol;sulfuric acid

2.1.2 InChI

InChI=1S/C17H19NO3.H2O4S/c1-18-7-6-17-10-3-5-13(20)16(17)21-15-12(19)4-2-9(14(15)17)8-11(10)18;1-5(2,3)4/h2-5,10-11,13,16,19-20H,6-8H2,1H3;(H2,1,2,3,4)/t10-,11+,13-,16-,17-;/m0./s1

2.1.3 InChI Key

OOZBZVAQKFGLOL-VYKNHSEDSA-N

2.1.4 Canonical SMILES

CN1CCC23C4C1CC5=C2C(=C(C=C5)O)OC3C(C=C4)O.OS(=O)(=O)O

2.1.5 Isomeric SMILES

CN1CC[C@]23[C@@H]4[C@H]1CC5=C2C(=C(C=C5)O)O[C@H]3[C@H](C=C4)O.OS(=O)(=O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Chloride, Morphine

2. Contin, Ms

3. Duramorph

4. Morphia

5. Morphine

6. Morphine Chloride

7. Morphine Sulfate

8. Morphine Sulfate (2:1), Anhydrous

9. Morphine Sulfate (2:1), Pentahydrate

10. Ms Contin

11. Oramorph Sr

12. Sdz 202 250

13. Sdz 202-250

14. Sdz 202250

15. Sdz202 250

16. Sdz202-250

17. Sdz202250

18. Sulfate, Morphine

2.2.2 Depositor-Supplied Synonyms

1. Morphine Sulfate

2. Schembl29317

3. Morphinesulfatenarcoticanalgesic

2.3 Create Date

2005-08-08

3 Chemical and Physical Properties

Molecular Formula	C₁₇H₂₁NO₇S
Molecular Weight	383.4 g/mol
Hydrogen Bond Donor Count	4
Hydrogen Bond Acceptor Count	8
Rotatable Bond Count	0
Exact Mass	383.10387318 g/mol
Monoisotopic Mass	383.10387318 g/mol
Topological Polar Surface Area	136 Å²
Heavy Atom Count	26
Formal Charge	0
Complexity	576
Isotope Atom Count	0
Defined Atom Stereocenter Count	5
Undefined Atom Stereocenter Count	0
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Drug and Medication Information

4.1 Drug Information

1 of 6
Drug Name	Astramorph pf
PubMed Health	Morphine (Injection)
Active Ingredient	Morphine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml; 0.5mg/ml
Market Status	Prescription
Company	Fresenius Kabi Usa

2 of 6
Drug Name	Duramorph pf
Active Ingredient	Morphine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml; 0.5mg/ml
Market Status	Prescription
Company	Hikma Maple

3 of 6
Drug Name	Morphine sulfate
PubMed Health	Morphine Sulfate Liposome (Injection)
Drug Classes	Analgesic, Anesthetic Adjunct, Central Nervous System Agent
Drug Label	DESCRIPTIONChemically, morphine sulfate is 7, 8-didehydro-4, 5-epoxy-17-methylmorphinan-3, 6-diol sulfate (2:1) (salt) pentahydrate...
Active Ingredient	Morphine sulfate
Dosage Form	Tablet, extended release; Tablet; Injectable; Capsule, extended release; Solution
Route	Intramuscular, intravenous; oral; Injection; Oral
Strength	2mg/ml; 200mg; 10mg/5ml; 1mg/ml; 8mg/ml (8mg/ml); 30mg; 10mg/ml (10mg/ml); 100mg/5ml; 90mg; 15mg; 120mg; 4mg/ml (4mg/ml); 10mg/ml; 0.5mg/ml; 2mg/ml (2mg/ml); 75mg; 4mg/ml; 5mg/ml; 100mg; 5mg/ml (5mg/ml); 8mg/ml; 50mg; 60mg; 10mg; 15mg/ml; 20mg/5ml; 80mg;
Market Status	Prescription
Company	Clonmel Hlthcare; Vintage Pharms; Mylan Pharms; Upsher Smith; Hospira; Mallinckrodt; Rhodes Pharms; Meridian Medcl; Par Pharm; Roxane; Lannett Holdings; Nesher Pharms; Vistapharm; Actavis Elizabeth; Paddock; Caraco; Ranbaxy Labs; Bd Rx

4 of 6
Drug Name	Astramorph pf
PubMed Health	Morphine (Injection)
Active Ingredient	Morphine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml; 0.5mg/ml
Market Status	Prescription
Company	Fresenius Kabi Usa

5 of 6
Drug Name	Duramorph pf
Active Ingredient	Morphine sulfate
Dosage Form	Injectable
Route	Injection
Strength	1mg/ml; 0.5mg/ml
Market Status	Prescription
Company	Hikma Maple

6 of 6
Drug Name	Morphine sulfate
PubMed Health	Morphine Sulfate Liposome (Injection)
Drug Classes	Analgesic, Anesthetic Adjunct, Central Nervous System Agent
Drug Label	DESCRIPTIONChemically, morphine sulfate is 7, 8-didehydro-4, 5-epoxy-17-methylmorphinan-3, 6-diol sulfate (2:1) (salt) pentahydrate...
Active Ingredient	Morphine sulfate
Dosage Form	Tablet, extended release; Tablet; Injectable; Capsule, extended release; Solution
Route	Intramuscular, intravenous; oral; Injection; Oral
Strength	2mg/ml; 200mg; 10mg/5ml; 1mg/ml; 8mg/ml (8mg/ml); 30mg; 10mg/ml (10mg/ml); 100mg/5ml; 90mg; 15mg; 120mg; 4mg/ml (4mg/ml); 10mg/ml; 0.5mg/ml; 2mg/ml (2mg/ml); 75mg; 4mg/ml; 5mg/ml; 100mg; 5mg/ml (5mg/ml); 8mg/ml; 50mg; 60mg; 10mg; 15mg/ml; 20mg/5ml; 80mg;
Market Status	Prescription
Company	Clonmel Hlthcare; Vintage Pharms; Mylan Pharms; Upsher Smith; Hospira; Mallinckrodt; Rhodes Pharms; Meridian Medcl; Par Pharm; Roxane; Lannett Holdings; Nesher Pharms; Vistapharm; Actavis Elizabeth; Paddock; Caraco; Ranbaxy Labs; Bd Rx

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Analgesics, Opioid

Compounds with activity like OPIATE ALKALOIDS, acting at OPIOID RECEPTORS. Properties include induction of ANALGESIA or NARCOSIS. (See all compounds classified as Analgesics, Opioid.)

Narcotics

Agents that induce NARCOSIS. Narcotics include agents that cause somnolence or induced sleep (STUPOR); natural or synthetic derivatives of OPIUM or MORPHINE or any substance that has such effects. They are potent inducers of ANALGESIA and OPIOID-RELATED DISORDERS. (See all compounds classified as Narcotics.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Opioid Agonist [EPC]; Full Opioid Agonists [MoA]

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