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    Technical details about Cromolyn Sodium, learn more about the structure, uses, toxicity, action, side effects and more

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    Cromolyn Sodium

    APIs // Active Pharmaceutical Ingredients

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    2D Structure
    Also known as: 15826-37-6, Sodium cromoglycate, Disodium cromoglycate, Sodium cromoglicate, Sodium cromolyn, Cromolyn sodium salt
    Molecular Formula
    C23H14Na2O11
    Molecular Weight
    512.3  g/mol
    InChI Key
    VLARUOGDXDTHEH-UHFFFAOYSA-L
    FDA UNII
    Q2WXR1I0PK
    A chromone complex that acts by inhibiting the release of chemical mediators from sensitized mast cells. It is used in the prophylactic treatment of both allergic and exercise-induced asthma, but does not affect an established asthmatic attack.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate
    2.1.2 InChI
    InChI=1S/C23H16O11.2Na/c24-11(9-31-14-3-1-5-16-20(14)12(25)7-18(33-16)22(27)28)10-32-15-4-2-6-17-21(15)13(26)8-19(34-17)23(29)30;;/h1-8,11,24H,9-10H2,(H,27,28)(H,29,30);;/q;2*+1/p-2
    2.1.3 InChI Key
    VLARUOGDXDTHEH-UHFFFAOYSA-L
    2.1.4 Canonical SMILES
    C1=CC2=C(C(=C1)OCC(COC3=CC=CC4=C3C(=O)C=C(O4)C(=O)[O-])O)C(=O)C=C(O2)C(=O)[O-].[Na+].[Na+]
    2.2 Other Identifiers
    2.2.1 UNII
    Q2WXR1I0PK
    2.3 Synonyms
    2.3.1 MeSH Synonyms

    1. Aarane

    2. Acid, Cromoglicic

    3. Acid, Cromoglycic

    4. Bicromat Spray

    5. Cromoglicic Acid

    6. Cromoglycate

    7. Cromoglycate, Disodium

    8. Cromoglycate, Sodium

    9. Cromoglycic Acid

    10. Cromolyn

    11. Disodium Cromoglycate

    12. Fpl 670

    13. Fpl-670

    14. Fpl670

    15. Intal

    16. Lomudal

    17. Nalcrom

    18. Nasalcrom

    19. Opticrom

    20. Sodium Cromoglycate

    21. Vicrom

    2.3.2 Depositor-Supplied Synonyms

    1. 15826-37-6

    2. Sodium Cromoglycate

    3. Disodium Cromoglycate

    4. Sodium Cromoglicate

    5. Sodium Cromolyn

    6. Cromolyn Sodium Salt

    7. Gastrocrom

    8. Nasalcrom

    9. Opticrom

    10. Intal

    11. Cromolyn Disodium Salt

    12. Cromoptic

    13. Crolom

    14. Cromoglycate Disodium

    15. Natrii Cromoglicas

    16. Natrium Cromoglicat

    17. Lomudal

    18. Nalcrom

    19. Aarane

    20. Fpl-670

    21. Chromolyn Sodium

    22. Cromoglicate Sodium

    23. Cromolyn (sodium)

    24. Aararre

    25. Frenasma

    26. Lomudas

    27. Lomusol

    28. Nebulasma

    29. Rynacrom

    30. Nasmil

    31. Astilyn

    32. Cromo Asma Aerosol

    33. Disodium Cromolyn

    34. Dinatrium Cromoglicicum

    35. Fpl 670

    36. Fpl.670

    37. Chebi:128458

    38. Q2wxr1i0pk

    39. Cromoglicic Acid;duracroman

    40. Disodium Cromoglycate;fpl-670

    41. Dinatrium Salz Von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan

    42. Disodium 5,5'-((2-hydroxytrimethylene)bis(oxy))bis(4-oxo-4h-1-benzopyran-2-carboxylate)

    43. Disodium 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4h-1-benzopyran-2-carboxylate)

    44. Nsc-109500

    45. 4h-1-benzopyran-2-carboxylic Acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, Disodium Salt)

    46. Gastrofrenal

    47. Lomuda

    48. Intal Nebulizer

    49. Cas-15826-37-6

    50. Dsstox_cid_24554

    51. Dsstox_rid_80311

    52. Cromolyn Sodium Hydrate

    53. Dsstox_gsid_44554

    54. Disodium;5-[3-(2-carboxylato-4-oxochromen-5-yl)oxy-2-hydroxypropoxy]-4-oxochromene-2-carboxylate

    55. Cromolyn Sodium [usan]

    56. Inostral (anti-asthmatic)

    57. Natrium Cromoglicat [german]

    58. Ccris 3194

    59. Ncgc00021142-02

    60. 4h-1-benzopyran-2-carboxylicacid, 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis[4-oxo-, Sodium Salt (1:2)

    61. Einecs 239-926-7

    62. Unii-q2wxr1i0pk

    63. Sodium Cromoglicate [jan]

    64. Nsc 109500

    65. Cromolyn Sodium [usan:usp]

    66. Cromlyn Sodio

    67. Cromoglicinsaeure, Dinatriumsalz

    68. Cromolina Sodica

    69. Cromolyn Na

    70. Cromolyne Sodique

    71. 1,3-di(2-carboxy-4-oxochromen-5-yloxy)propan-2-ol

    72. Methyl3-butynoate

    73. Disodium 5,5'-[(2-hydroxypropane-1,3-diyl)bis(oxy)]bis(4-oxo-4h-chromene-2-carboxylate)

    74. Gastrocrom (tn)

    75. Prestwick_996

    76. Mfcd00057744

    77. Cromoglicato De Sodio

    78. Intal (tn)

    79. 5,5'-(2-hydroxytrimethylenedioxy)bis(4-oxochromene-2-carboxylic Acid)

    80. Cromolyn Sodium (usp)

    81. Chembl74

    82. 5,5'-[(2-hydroxy-1,3-propanediyl)bis(oxy)]bis(4-oxo-4h-1-benzopyran-2-carboxylic Acid) Disodium Salt

    83. Epitope Id:122681

    84. Dinatrium Salz Von 1,3-bis-(2-carboxychromon-5-yloxy)-2-hydroxypropan [german]

    85. Schembl7500

    86. 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-4h-1-benzopyran-2-carboxylic Acid) Disodium Salt

    87. Cromoglycate,cromoglycic Acid

    88. Sodium Cromoglicate (jp17)

    89. Spectrum1500210

    90. Cromolyn Sodium [vandf]

    91. Fpl 670 (cromolyn) Disodium

    92. Disodium Cromolyn [inci]

    93. Dtxsid7044554

    94. Hms502k19

    95. Cromolyn Sodium [usp-rs]

    96. Hms1570d05

    97. Hms1920a18

    98. Hms2089n09

    99. Hms2091i06

    100. Hms2097d05

    101. Hms3714d05

    102. Bcp12933

    103. Cromolyn Disodium Salt [mi]

    104. Sodium Cromoglicate [mart.]

    105. Tox21_110863

    106. Tox21_302003

    107. Ccg-40261

    108. Cromoglicate Sodium [who-dd]

    109. S1911

    110. Sodium Cromoglicate [who-ip]

    111. Cromolyn Sodium [orange Book]

    112. Akos015895760

    113. Akos015913923

    114. Tox21_110863_1

    115. Cromolyn Sodium [usp Monograph]

    116. Ks-5299

    117. Ncgc00017083-01

    118. Ncgc00017083-02

    119. Ncgc00017083-03

    120. Ncgc00022858-08

    121. Ncgc00094633-01

    122. Ncgc00094633-02

    123. Ncgc00255950-01

    124. 4h-1-benzopyran-2-carboxylic Acid, 5,5'-((2-hydroxytrimethylene)dioxy)bis(4-oxo-, Disodium Salt

    125. Ac-18734

    126. Natrii Cromoglicas [who-ip Latin]

    127. Sodium Cromoglicate [ep Monograph]

    128. B3300

    129. Ft-0602030

    130. D00526

    131. A809913

    132. J-009487

    133. Q10261779

    134. Sodium 5,5'-(2-hydroxypropane-1,3-diyl)bis(oxy)bis(4-oxo-4h-chromene-2-carboxylate)

    135. 4h-1-benzopyran-2-carboxylic Acid, 5,5'-((2-hydroxy-1,3-propanediyl)bis(oxy))bis(4-oxo-, Disodium Salt

    136. Disodium 5-[3-(2-carboxylato-4-oxo-4h-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4h-2-chromenecarboxylate

    137. Disodium 5-{3-[(2-carboxylato-4-oxo-4h-chromen-5-yl)oxy]-2-hydroxypropoxy}-4-oxo-4h-chromene-2-carboxylate

    138. Sodium 5-[3-(2-carboxy-4-oxo-chromen-5-yl)oxy-2-hydroxy-propoxy]-4-oxo-chromene-2-carboxylic Acid;sodium Cromoylycate

    139. Sodium Salt Of 5-[3-(2-carboxy-4-oxo-4h-5-chromenyloxy)-2-hydroxypropoxy]-4-oxo-4h-2-chromenecarboxylic Acid

    2.4 Create Date
    2005-06-24
    3 Chemical and Physical Properties
    Molecular Weight 512.3 g/mol
    Molecular Formula C23H14Na2O11
    Hydrogen Bond Donor Count1
    Hydrogen Bond Acceptor Count11
    Rotatable Bond Count6
    Exact Mass512.03314982 g/mol
    Monoisotopic Mass512.03314982 g/mol
    Topological Polar Surface Area172 Ų
    Heavy Atom Count36
    Formal Charge0
    Complexity824
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count3
    4 Drug and Medication Information
    4.1 Drug Information
    1 of 6  
    Drug NameCrolom
    PubMed HealthCromolyn (Into the eye)
    Drug ClassesOphthalmologic Agent
    Drug LabelCrolom (cromolyn sodium ophthalmic solution USP, 4%) is a clear, colorless, sterile solution for topical ophthalmic use. Cromolyn sodium is represented by the following structural formula:C23H14Na2O11...
    Active IngredientCromolyn sodium
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength4%
    Market StatusPrescription
    CompanyBausch And Lomb

    2 of 6  
    Drug NameCromolyn sodium
    PubMed HealthCromolyn
    Drug ClassesAntiasthma, Gastrointestinal Agent, Nasal Agent, Ophthalmologic Agent
    Drug LabelThe active ingredient of cromolyn sodium inhalation solution, USP is cromolyn sodium, USP. It is an inhaled anti-inflammatory agent for the preventive management of asthma. Cromolyn sodium is chemically designated as disodium 5,5'- [(2-hydroxytrimeth
    Active IngredientCromolyn sodium
    Dosage FormSolution/drops; Spray, metered; Concentrate; Solution
    RouteNasal; Inhalation; Ophthalmic; Oral
    Strength5.2mg/spray; 100mg/5ml; 4%; 10mg/ml
    Market StatusOver the Counter; Prescription
    CompanyWockhardt; Alcon; Teva Pharms; Micro Labs Ltd India; Pack Pharms; Bausch And Lomb; Perrigo; Mylan Speclt; Akorn

    3 of 6  
    Drug NameGastrocrom
    Drug LabelEach 5 mL ampule of GASTROCROM contains 100 mg cromolyn sodium, USP, in purified water. Cromolyn sodium is a hygroscopic, white powder having little odor. It may leave a slightly bitter aftertaste. GASTROCROM (cromolyn sodium, USP) Oral Concentrate i...
    Active IngredientCromolyn sodium
    Dosage FormConcentrate
    RouteOral
    Strength100mg/5ml
    Market StatusPrescription
    CompanyMeda Pharms

    4 of 6  
    Drug NameCrolom
    PubMed HealthCromolyn (Into the eye)
    Drug ClassesOphthalmologic Agent
    Drug LabelCrolom (cromolyn sodium ophthalmic solution USP, 4%) is a clear, colorless, sterile solution for topical ophthalmic use. Cromolyn sodium is represented by the following structural formula:C23H14Na2O11...
    Active IngredientCromolyn sodium
    Dosage FormSolution/drops
    RouteOphthalmic
    Strength4%
    Market StatusPrescription
    CompanyBausch And Lomb

    5 of 6  
    Drug NameCromolyn sodium
    PubMed HealthCromolyn
    Drug ClassesAntiasthma, Gastrointestinal Agent, Nasal Agent, Ophthalmologic Agent
    Drug LabelThe active ingredient of cromolyn sodium inhalation solution, USP is cromolyn sodium, USP. It is an inhaled anti-inflammatory agent for the preventive management of asthma. Cromolyn sodium is chemically designated as disodium 5,5'- [(2-hydroxytrimeth
    Active IngredientCromolyn sodium
    Dosage FormSolution/drops; Spray, metered; Concentrate; Solution
    RouteNasal; Inhalation; Ophthalmic; Oral
    Strength5.2mg/spray; 100mg/5ml; 4%; 10mg/ml
    Market StatusOver the Counter; Prescription
    CompanyWockhardt; Alcon; Teva Pharms; Micro Labs Ltd India; Pack Pharms; Bausch And Lomb; Perrigo; Mylan Speclt; Akorn

    6 of 6  
    Drug NameGastrocrom
    Drug LabelEach 5 mL ampule of GASTROCROM contains 100 mg cromolyn sodium, USP, in purified water. Cromolyn sodium is a hygroscopic, white powder having little odor. It may leave a slightly bitter aftertaste. GASTROCROM (cromolyn sodium, USP) Oral Concentrate i...
    Active IngredientCromolyn sodium
    Dosage FormConcentrate
    RouteOral
    Strength100mg/5ml
    Market StatusPrescription
    CompanyMeda Pharms

    5 Pharmacology and Biochemistry
    5.1 MeSH Pharmacological Classification

    Mast Cell Stabilizers

    Compounds that prevent the release of inflammatory mediators from MAST CELLS. (See all compounds classified as Mast Cell Stabilizers.)

    Anti-Asthmatic Agents

    Drugs that are used to treat asthma. (See all compounds classified as Anti-Asthmatic Agents.)

    5.2 FDA Pharmacological Classification
    5.2.1 Pharmacological Classes
    Mast Cell Stabilizer [EPC]; Decreased Histamine Release [PE]
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