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    Technical details about Alteplase, learn more about the structure, uses, toxicity, action, side effects and more

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    Alteplase

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    2D Structure
    1. Also known as: 177799-16-5, Ttpa, 9,10-bis[n,n-di(p-tolyl)amino]anthracene, 9-n,9-n,10-n,10-n-tetrakis(4-methylphenyl)anthracene-9,10-diamine, N9,n9,n10,n10-tetra-p-tolylanthracene-9,10-diamine, Schembl1261345
    Molecular Formula
    C42H36N2
    Molecular Weight
    568.7  g/mol
    InChI Key
    FWXNJWAXBVMBGL-UHFFFAOYSA-N
    A proteolytic enzyme in the serine protease family found in many tissues which converts PLASMINOGEN to FIBRINOLYSIN. It has fibrin-binding activity and is immunologically different from UROKINASE-TYPE PLASMINOGEN ACTIVATOR. The primary sequence, composed of 527 amino acids, is identical in both the naturally occurring and synthetic proteases.
    1 2D Structure

    2D Structure

    2 Identification
    2.1 Computed Descriptors
    2.1.1 IUPAC Name
    9-N,9-N,10-N,10-N-tetrakis(4-methylphenyl)anthracene-9,10-diamine
    2.1.2 InChI
    InChI=1S/C42H36N2/c1-29-13-21-33(22-14-29)43(34-23-15-30(2)16-24-34)41-37-9-5-7-11-39(37)42(40-12-8-6-10-38(40)41)44(35-25-17-31(3)18-26-35)36-27-19-32(4)20-28-36/h5-28H,1-4H3
    2.1.3 InChI Key
    FWXNJWAXBVMBGL-UHFFFAOYSA-N
    2.1.4 Canonical SMILES
    CC1=CC=C(C=C1)N(C2=CC=C(C=C2)C)C3=C4C=CC=CC4=C(C5=CC=CC=C53)N(C6=CC=C(C=C6)C)C7=CC=C(C=C7)C
    2.2 Synonyms
    2.2.1 MeSH Synonyms

    1. Actilyse

    2. Activase

    3. Alteplase

    4. Lysatec Rt Pa

    5. Lysatec Rt-pa

    6. Lysatec Rtpa

    7. Plasminogen Activator, Tissue

    8. Plasminogen Activator, Tissue Type

    9. Plasminogen Activator, Tissue-type

    10. T Plasminogen Activator

    11. T-plasminogen Activator

    12. Tisokinase

    13. Tissue Activator D 44

    14. Tissue Activator D-44

    15. Tissue Plasminogen Activator

    16. Tissue Type Plasminogen Activator

    17. Tissue-type Plasminogen Activator

    18. Ttpa

    2.2.2 Depositor-Supplied Synonyms

    1. 177799-16-5

    2. Ttpa

    3. 9,10-bis[n,n-di(p-tolyl)amino]anthracene

    4. 9-n,9-n,10-n,10-n-tetrakis(4-methylphenyl)anthracene-9,10-diamine

    5. N9,n9,n10,n10-tetra-p-tolylanthracene-9,10-diamine

    6. Schembl1261345

    7. Dtxsid30629288

    8. Cha79916

    9. 9,10-anthracenediamine, N9,n9,n10,n10-tetrakis(4-methylphenyl)-

    10. Mfcd12022465

    11. Akos027252460

    12. As-71559

    13. 9,10-bis[n,n-di(p-tolyl)amino]anthracene, 98%

    14. N,n,n',n'-tetrakis(p-tolyl)anthracene-9,10-diamine

    15. N,n,n',n'-tetrakis(4-methylphenyl)-9,10-anthracenediamine

    16. N~9~,n~9~,n~10~,n~10~-tetrakis(4-methylphenyl)anthracene-9,10-diamine

    17. N9,n9,n10,n10-tetrakis(4-methylphenyl)anthracene-9,10-diamine

    2.3 Create Date
    2007-12-05
    3 Chemical and Physical Properties
    Molecular Weight 568.7 g/mol
    Molecular Formula C42H36N2
    XLogP312.4
    Hydrogen Bond Donor Count0
    Hydrogen Bond Acceptor Count2
    Rotatable Bond Count6
    Exact Mass568.287849157 g/mol
    Monoisotopic Mass568.287849157 g/mol
    Topological Polar Surface Area6.5 Ų
    Heavy Atom Count44
    Formal Charge0
    Complexity728
    Isotope Atom Count0
    Defined Atom Stereocenter Count0
    Undefined Atom Stereocenter Count0
    Defined Bond Stereocenter Count0
    Undefined Bond Stereocenter Count0
    Covalently Bonded Unit Count1
    4 Pharmacology and Biochemistry
    4.1 MeSH Pharmacological Classification

    Fibrinolytic Agents

    Fibrinolysin or agents that convert plasminogen to FIBRINOLYSIN. (See all compounds classified as Fibrinolytic Agents.)

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