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Chemistry

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Also known as: 845273-93-0, 2-propen-1-amine polymer with (chloromethyl)oxirane carbonate, Carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine, Sevelamercarbonate, Gt-335-012, Chembl1201799
Molecular Formula
C7H14ClNO4
Molecular Weight
211.64  g/mol
InChI Key
PADGNZFOVSZIKZ-UHFFFAOYSA-N

Sevelamer Carbonate
A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.
1 2D Structure

Sevelamer Carbonate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine
2.1.2 InChI
InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)
2.1.3 InChI Key
PADGNZFOVSZIKZ-UHFFFAOYSA-N
2.1.4 Canonical SMILES
C=CCN.C1C(O1)CCl.C(=O)(O)O
2.2 Synonyms
2.2.1 MeSH Synonyms

1. Carbonate, Sevelamer

2. Gt335 012

3. Gt335-012

4. Gt335012

5. Hydrochloride, Sevelamer

6. Renagel

7. Sevelamer

8. Sevelamer Hydrochloride

2.2.2 Depositor-Supplied Synonyms

1. 845273-93-0

2. 2-propen-1-amine Polymer With (chloromethyl)oxirane Carbonate

3. Carbonic Acid;2-(chloromethyl)oxirane;prop-2-en-1-amine

4. Sevelamercarbonate

5. Gt-335-012

6. Chembl1201799

7. Bcp13411

8. Ex-a4743

9. Akos037515475

10. Hs-0081

11. Gt335-012

12. Gt335 012;gt335-012;gt335012;carbonate, Sevelamer

2.3 Create Date
2006-10-26
3 Chemical and Physical Properties
Molecular Weight 211.64 g/mol
Molecular Formula C7H14ClNO4
Hydrogen Bond Donor Count3
Hydrogen Bond Acceptor Count5
Rotatable Bond Count2
Exact Mass211.0611356 g/mol
Monoisotopic Mass211.0611356 g/mol
Topological Polar Surface Area96.1 Ų
Heavy Atom Count13
Formal Charge0
Complexity81.4
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count3
4 Drug and Medication Information
4.1 Drug Indication

Renvela is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.

Renvela is also indicated for the control of hyperphosphataemia in adult patients with chronic kidney disease not on dialysis with serum phosphorus 1. 78 mmol/l.

Renvela should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy vitamin D3 or one of its analogues to control the development of renal bone disease.


Sevelamer carbonate Winthrop is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.

Sevelamer carbonate Winthrop is also indicated for the control of hyperphosphataemia in adult patients with chronic kidney disease not on dialysis with serum phosphorus > 1. 78 mmol/L.

Sevelamer carbonate Winthrop should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy Vitamin D3 or one of its analogues to control the development of renal bone disease.


5 Pharmacology and Biochemistry
5.1 MeSH Pharmacological Classification

Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)


5.2 FDA Pharmacological Classification
5.2.1 Pharmacological Classes
Phosphate Chelating Activity [MoA]; Phosphate Binder [EPC]
5.3 ATC Code

V03AE02


V03AE02


API Reference Price

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12-Jan-2021
29-Aug-2024
KGS
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