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Technical details about Sevelamer Carbonate, learn more about the structure, uses, toxicity, action, side effects and more

Sevelamer Carbonate

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

29 Suppliers, 19 USDMF, 9 EU WC, 9 KDMF, 8 NDC API, 15 Listed Suppliers

DEVELOPMENTS

2 Drug(s) in Development

2 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Imports

INTERMEDIATES

2 Suppliers

2 Suppliers

DOSSIERs // Finished Dosage Forms

63 Dossiers, 32 FDA Orange Book, 10 Europe, 4 Canada, 1 South Africa, 16 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 19 Kerry, 14 Roquette, 14 SPI Pharma, 13 DKSH, 10 BASF, 10 Corel Pharma Chem, 9 Sigachi Industries, 9 Gangwal Healthcare, 9 Gangwal Chemicals, 8 Microlex e.U, 7 Seppic, 7 Ideal Cures Pvt Ltd, 6 Lonza Capsugel, 5 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 4 Boai NKY Pharmaceuticals Ltd, 3 Rochem International Inc, 3 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 3 Nanjing Well Pharmaceutical, 3 Kima Chemical, 3 Actylis, 3 Pharmatrans-Sanaq, 2 Pharm-RX Chemical, 2 Alcedo Pharmachem, 2 DFE Pharma, 2 The Dow Chemical Company, 2 Prachin Chemical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 NEWEDGE Overseas, 1 Qualicaps, 1 Shijiazhuang Huaxu Pharmaceutical, 1 Chynops Pharma, 1 Valens Pharmachem, 1 Ingredion Pharma Solutions, 1 Ulanqab Kema New Material, 1 Minakem, 1 Finar, 1 Aeon Procare, 1 Bioplus Life Sciences, 1 Vasa Pharmachem, 1 Jai Radhe Sales, 1 ACG Worldwide

EXCIPIENTS BY APPLICATIONS

53 Coating Systems & Additives, 47 Fillers, Diluents & Binders, 27 Direct Compression, 24 Controlled & Modified Release, 21 Disintegrants & Superdisintegrants, 19 Thickeners and Stabilizers, 16 Chewable & Orodispersible Aids, 16 Lubricants & Glidants, 15 Granulation, 14 Taste Masking, 13 Film Formers & Plasticizers, 10 Co-Processed Excipients, 9 Parenteral, 8 Solubilizers, 8 Topical, 7 API Stability Enhancers, 5 Empty Capsules, 5 Coloring Agents, 5 Emulsifying Agents, 4 Vegetarian Capsules, 4 Rheology Modifiers

GLOBAL SALES INFORMATION

2 US Medicaid Prescriptions

2 US Medicaid Prescriptions

MARKET PLACE

11 APIs, 4 DOSSIERS // FDF

PATENTS

3 US Patents, 3 Health Canada Patents

DIGITAL CONTENT

1 Data Compilation & Company Tracker #PharmaFlow, 20 News

1. Also known as: 845273-93-0, 2-propen-1-amine polymer with (chloromethyl)oxirane carbonate, Carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine, Sevelamercarbonate, Gt-335-012, Chembl1201799

Molecular Formula

C₇H₁₄ClNO₄

Molecular Weight

211.64 g/mol

InChI Key

PADGNZFOVSZIKZ-UHFFFAOYSA-N

A polymeric amine that binds phosphate and is used to treat HYPERPHOSPHATEMIA in patients with kidney disease.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

carbonic acid;2-(chloromethyl)oxirane;prop-2-en-1-amine

2.1.2 InChI

InChI=1S/C3H5ClO.C3H7N.CH2O3/c4-1-3-2-5-3;1-2-3-4;2-1(3)4/h3H,1-2H2;2H,1,3-4H2;(H2,2,3,4)

2.1.3 InChI Key

PADGNZFOVSZIKZ-UHFFFAOYSA-N

2.1.4 Canonical SMILES

C=CCN.C1C(O1)CCl.C(=O)(O)O

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Carbonate, Sevelamer

2. Gt335 012

3. Gt335-012

4. Gt335012

5. Hydrochloride, Sevelamer

6. Renagel

7. Sevelamer

8. Sevelamer Hydrochloride

2.2.2 Depositor-Supplied Synonyms

1. 845273-93-0

2. 2-propen-1-amine Polymer With (chloromethyl)oxirane Carbonate

3. Carbonic Acid;2-(chloromethyl)oxirane;prop-2-en-1-amine

4. Sevelamercarbonate

5. Gt-335-012

6. Chembl1201799

7. Bcp13411

8. Ex-a4743

9. Akos037515475

10. Hs-0081

11. Gt335-012

12. Gt335 012;gt335-012;gt335012;carbonate, Sevelamer

2.3 Create Date

2006-10-26

3 Chemical and Physical Properties

Molecular Formula	C₇H₁₄ClNO₄
Molecular Weight	211.64 g/mol
Hydrogen Bond Donor Count	3
Hydrogen Bond Acceptor Count	5
Rotatable Bond Count	2
Exact Mass	211.0611356 g/mol
Monoisotopic Mass	211.0611356 g/mol
Topological Polar Surface Area	96.1 Å²
Heavy Atom Count	13
Formal Charge	0
Complexity	81.4
Isotope Atom Count	0
Defined Atom Stereocenter Count	0
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	3

4 Drug and Medication Information

4.1 Drug Indication

Renvela is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.

Renvela is also indicated for the control of hyperphosphataemia in adult patients with chronic kidney disease not on dialysis with serum phosphorus 1. 78 mmol/l.

Renvela should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy vitamin D3 or one of its analogues to control the development of renal bone disease.

Sevelamer carbonate Winthrop is indicated for the control of hyperphosphataemia in adult patients receiving haemodialysis or peritoneal dialysis.

Sevelamer carbonate Winthrop is also indicated for the control of hyperphosphataemia in adult patients with chronic kidney disease not on dialysis with serum phosphorus > 1. 78 mmol/L.

Sevelamer carbonate Winthrop should be used within the context of a multiple therapeutic approach, which could include calcium supplement, 1,25-dihydroxy Vitamin D3 or one of its analogues to control the development of renal bone disease.

5 Pharmacology and Biochemistry

5.1 MeSH Pharmacological Classification

Chelating Agents

Chemicals that bind to and remove ions from solutions. Many chelating agents function through the formation of COORDINATION COMPLEXES with METALS. (See all compounds classified as Chelating Agents.)

5.2 FDA Pharmacological Classification

5.2.1 Pharmacological Classes

Phosphate Chelating Activity [MoA]; Phosphate Binder [EPC]

5.3 ATC Code

V03AE02

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