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Also known as: 59703-84-3, Pipracil, Piperacillin sodium salt, Sodium piperacillin, Piperacillin (sodium), Penmalin
Molecular Formula
C23H26N5NaO7S
Molecular Weight
539.5  g/mol
InChI Key
WCMIIGXFCMNQDS-IDYPWDAWSA-M
FDA UNII
M98T69Q7HP

Piperacillin Sodium
Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.
1 2D Structure

Piperacillin Sodium

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
sodium;(2S,5R,6R)-6-[[(2R)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate
2.1.2 InChI
InChI=1S/C23H27N5O7S.Na/c1-4-26-10-11-27(19(32)18(26)31)22(35)25-13(12-8-6-5-7-9-12)16(29)24-14-17(30)28-15(21(33)34)23(2,3)36-20(14)28;/h5-9,13-15,20H,4,10-11H2,1-3H3,(H,24,29)(H,25,35)(H,33,34);/q;+1/p-1/t13-,14-,15+,20-;/m1./s1
2.1.3 InChI Key
WCMIIGXFCMNQDS-IDYPWDAWSA-M
2.1.4 Canonical SMILES
CCN1CCN(C(=O)C1=O)C(=O)NC(C2=CC=CC=C2)C(=O)NC3C4N(C3=O)C(C(S4)(C)C)C(=O)[O-].[Na+]
2.1.5 Isomeric SMILES
CCN1CCN(C(=O)C1=O)C(=O)N[C@H](C2=CC=CC=C2)C(=O)N[C@H]3[C@@H]4N(C3=O)[C@H](C(S4)(C)C)C(=O)[O-].[Na+]
2.2 Other Identifiers
2.2.1 UNII
M98T69Q7HP
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Ab Piperacillin

2. Ab-piperacillin

3. Cl 227193

4. Cl-227193

5. Cl227193

6. Curasan, Piperacillin

7. Monosodium Salt, Piperacillin

8. Pipcil

9. Pipera Hameln

10. Pipera-hameln

11. Piperacillin

12. Piperacillin Curasan

13. Piperacillin Fresenius

14. Piperacillin Hexal

15. Piperacillin Monosodium Salt

16. Piperacillin Ratiopharm

17. Piperacillin-ratiopharm

18. Pipercillin

19. Pipracil

20. Pipril

21. Salt, Piperacillin Monosodium

22. Sodium, Piperacillin

23. T 1220

24. T-1220

25. T1220

2.3.2 Depositor-Supplied Synonyms

1. 59703-84-3

2. Pipracil

3. Piperacillin Sodium Salt

4. Sodium Piperacillin

5. Piperacillin (sodium)

6. Penmalin

7. Piperacillin (as Sodium)

8. Mls000069533

9. Chebi:8233

10. M98t69q7hp

11. Cl 227,193

12. T-1220

13. Nsc-757277

14. Cl-227193

15. Sodium;(2s,5r,6r)-6-[[(2r)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

16. Smr000058579

17. Sodium (2s,5r,6r)-6-((r)-2-(4-ethyl-2,3-dioxo-1-piperazinecarboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylate

18. Sodium;(2s,5r,6r)-6-[[(2s)-2-[(4-ethyl-2,3-dioxopiperazine-1-carbonyl)amino]-2-phenylacetyl]amino]-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

19. Pentcillin

20. Pipracil Sterile

21. Unii-m98t69q7hp

22. 1-carboxamido)-2-phenylacetamido)-3,3-dimethyl-

23. Ccris 2591

24. Zosyn Sterile

25. Pentcillin (tn)

26. T 1220

27. Pipracil (tn)

28. Einecs 261-868-6

29. Mfcd00917471

30. Piperacillin Sodium [usan:usp:jan]

31. Prestwick_1028

32. Cl 227193

33. Opera_id_1140

34. Schembl34180

35. Mls002548888

36. Chembl1200820

37. Dtxsid6048965

38. Piperacillin Sodium [jan]

39. Piperacillin Sodium (jp17/usp)

40. Hms1570g12

41. Hms2097g12

42. Hms3259m09

43. Hms3714g12

44. Piperacillin Sodium [usan]

45. Piperacillin Sodium [vandf]

46. Hy-b1286

47. Cl227193

48. Piperacillin Sodium [who-dd]

49. S4222

50. Piperacillin Sodium Salt [mi]

51. Akos024464845

52. Ccg-220755

53. Cs-4894

54. Nc00477

55. Nsc 757277

56. Piperacillin Sodium [orange Book]

57. Piperacillin Sodium [ep Monograph]

58. Zosyn Component Piperacillin Sodium

59. Piperacillin Sodium [usp Monograph]

60. Piperacillin Sodium Salt, Penicillin Analog

61. P1774

62. Piperacillin Sodium Component Of Zosyn

63. Piperacillin Sodium Salt, Analytical Standard

64. C07361

65. D00466

66. Q-201585

67. Q27108010

68. 7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

69. Sodium (2s,5r,6r)-6-((r)-2-(4-ethyl-2,3-dioxopiperazine-

70. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, Monosodium Salt, (2s-(2.alpha.,5.alpha.,6.beta.(s*)))

71. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, Monosodium Salt, (2s-(2alpha,5alpha,6beta(s*)))

72. 4-thia-1-azabicyclo(3.2.0)heptane-2-carboxylic Acid, 6-(((((4-ethyl-2,3-dioxo-1-piperazinyl)carbonyl)amino)phenylacetyl)amino)-3,3-dimethyl-7-oxo-, Monosodium Salt, (2s-(2alpha,5alpha,6beta(s*)))-

73. Sodium (2s,5r,6r)-6-((r)-2-(4-ethyl-2,3-dioxopiperazine-1-carboxamido)-2-phenylacetamido)-3,3-dimethyl-7-oxo-4-thia-1-azabicyclo[3.2.0]heptane-2-carboxylate

74. Sodium 6beta-{(2r)-2-[(4-ethyl-2,3-dioxopiperazin-1-yl)carboxamido]-2-phenylacetamido}-2,2-dimethylpenam-3alpha-carboxylate

2.4 Create Date
2008-02-05
3 Chemical and Physical Properties
Molecular Weight 539.5 g/mol
Molecular Formula C23H26N5NaO7S
Hydrogen Bond Donor Count2
Hydrogen Bond Acceptor Count8
Rotatable Bond Count6
Exact Mass539.14506364 g/mol
Monoisotopic Mass539.14506364 g/mol
Topological Polar Surface Area185 Ų
Heavy Atom Count37
Formal Charge0
Complexity989
Isotope Atom Count0
Defined Atom Stereocenter Count4
Undefined Atom Stereocenter Count0
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Bacterial Agents

Substances that inhibit the growth or reproduction of BACTERIA. (See all compounds classified as Anti-Bacterial Agents.)


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01-Jan-2022
30-Apr-2025
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DRUG PRODUCT COMPOSITIONS

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DOSAGE - INJECTABLE;INJECTION - EQ 2GM BASE/V...DOSAGE - INJECTABLE;INJECTION - EQ 2GM BASE/VIAL;EQ 250MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50684

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DOSAGE - INJECTABLE;INJECTION - EQ 36GM BASE/...DOSAGE - INJECTABLE;INJECTION - EQ 36GM BASE/VIAL;EQ 4.5GM BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50684

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DOSAGE - INJECTABLE;INJECTION - EQ 3GM BASE/V...DOSAGE - INJECTABLE;INJECTION - EQ 3GM BASE/VIAL;EQ 375MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50684

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DOSAGE - INJECTABLE;INJECTION - EQ 4GM BASE/V...DOSAGE - INJECTABLE;INJECTION - EQ 4GM BASE/VIAL;EQ 500MG BASE/VIAL **Federal Register determination that product was not discontinued or withdrawn for safety or effectiveness reasons**

USFDA APPLICATION NUMBER - 50684

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DOSAGE - INJECTABLE;INJECTION - EQ 40MG BASE/...DOSAGE - INJECTABLE;INJECTION - EQ 40MG BASE/ML;EQ 5MG BASE/ML

USFDA APPLICATION NUMBER - 50750

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DOSAGE - INJECTABLE;INJECTION - EQ 4GM BASE/1...DOSAGE - INJECTABLE;INJECTION - EQ 4GM BASE/100ML;EQ 500MG BASE/100ML

USFDA APPLICATION NUMBER - 50750

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DOSAGE - INJECTABLE;INJECTION - EQ 60MG BASE/...DOSAGE - INJECTABLE;INJECTION - EQ 60MG BASE/ML;EQ 7.5MG BASE/ML

USFDA APPLICATION NUMBER - 50750

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ABOUT THIS PAGE

Looking for 59703-84-3 / Piperacillin Sodium API manufacturers, exporters & distributors?

Piperacillin Sodium manufacturers, exporters & distributors 1

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PharmaCompass offers a list of Piperacillin Sodium API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Piperacillin Sodium manufacturer or Piperacillin Sodium supplier for your needs.

Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Piperacillin Sodium manufacturer or Piperacillin Sodium supplier.

PharmaCompass also assists you with knowing the Piperacillin Sodium API Price utilized in the formulation of products. Piperacillin Sodium API Price is not always fixed or binding as the Piperacillin Sodium Price is obtained through a variety of data sources. The Piperacillin Sodium Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

API | Excipient name

Piperacillin Sodium

Synonyms

59703-84-3, Pipracil, Piperacillin sodium salt, Sodium piperacillin, Piperacillin (sodium), Penmalin

Cas Number

59703-84-3

Unique Ingredient Identifier (UNII)

M98T69Q7HP

About Piperacillin Sodium

Semisynthetic, broad-spectrum, AMPICILLIN derived ureidopenicillin antibiotic proposed for PSEUDOMONAS infections. It is also used in combination with other antibiotics.

Piperacillin Sodium Manufacturers

A Piperacillin Sodium manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Piperacillin Sodium, including repackagers and relabelers. The FDA regulates Piperacillin Sodium manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Piperacillin Sodium API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

click here to find a list of Piperacillin Sodium manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

Piperacillin Sodium Suppliers

A Piperacillin Sodium supplier is an individual or a company that provides Piperacillin Sodium active pharmaceutical ingredient (API) or Piperacillin Sodium finished formulations upon request. The Piperacillin Sodium suppliers may include Piperacillin Sodium API manufacturers, exporters, distributors and traders.

click here to find a list of Piperacillin Sodium suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

Piperacillin Sodium USDMF

A Piperacillin Sodium DMF (Drug Master File) is a document detailing the whole manufacturing process of Piperacillin Sodium active pharmaceutical ingredient (API) in detail. Different forms of Piperacillin Sodium DMFs exist exist since differing nations have different regulations, such as Piperacillin Sodium USDMF, ASMF (EDMF), JDMF, CDMF, etc.

A Piperacillin Sodium DMF submitted to regulatory agencies in the US is known as a USDMF. Piperacillin Sodium USDMF includes data on Piperacillin Sodium's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Piperacillin Sodium USDMF is kept confidential to protect the manufacturer’s intellectual property.

click here to find a list of Piperacillin Sodium suppliers with USDMF on PharmaCompass.

Piperacillin Sodium JDMF

The Pharmaceuticals and Medical Devices Agency (PMDA) established the Japan Drug Master File (JDMF), also known as the Master File (MF), to permit Japanese and foreign manufacturers of drug substances, intermediates, excipients, raw materials, and packaging materials (‘Products’) to voluntarily register confidential information about the production and management of their products in Japan.

The Piperacillin Sodium Drug Master File in Japan (Piperacillin Sodium JDMF) empowers Piperacillin Sodium API manufacturers to present comprehensive information (e.g., production methods, data, etc.) to the review authority, i.e., PMDA (Pharmaceuticals & Medical Devices Agency).

PMDA reviews the Piperacillin Sodium JDMF during the approval evaluation for pharmaceutical products. At the time of Piperacillin Sodium JDMF registration, PMDA checks if the format is accurate, if the necessary items have been included (application), and if data has been attached.

click here to find a list of Piperacillin Sodium suppliers with JDMF on PharmaCompass.

Piperacillin Sodium KDMF

In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.

Pharmaceutical companies submit a Piperacillin Sodium Drug Master File in Korea (Piperacillin Sodium KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of Piperacillin Sodium. The MFDS reviews the Piperacillin Sodium KDMF as part of the drug registration process and uses the information provided in the Piperacillin Sodium KDMF to evaluate the safety and efficacy of the drug.

After submitting a Piperacillin Sodium KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their Piperacillin Sodium API can apply through the Korea Drug Master File (KDMF).

click here to find a list of Piperacillin Sodium suppliers with KDMF on PharmaCompass.

Piperacillin Sodium CEP

A Piperacillin Sodium CEP of the European Pharmacopoeia monograph is often referred to as a Piperacillin Sodium Certificate of Suitability (COS). The purpose of a Piperacillin Sodium CEP is to show that the European Pharmacopoeia monograph adequately controls the purity of Piperacillin Sodium EP produced by a given manufacturer. Suppliers of raw materials can prove the suitability of Piperacillin Sodium to their clients by showing that a Piperacillin Sodium CEP has been issued for it. The manufacturer submits a Piperacillin Sodium CEP (COS) as part of the market authorization procedure, and it takes on the role of a Piperacillin Sodium CEP holder for the record. Additionally, the data presented in the Piperacillin Sodium CEP (COS) is managed confidentially and offers a centralized system acknowledged by numerous nations, exactly like the Piperacillin Sodium DMF.

A Piperacillin Sodium CEP (COS) is recognised by all 36 nations that make up the European Pharmacopoeia Convention. Piperacillin Sodium CEPs may be accepted in nations that are not members of the Ph. Eur. at the discretion of the authorities there.

click here to find a list of Piperacillin Sodium suppliers with CEP (COS) on PharmaCompass.

Piperacillin Sodium NDC

National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing Piperacillin Sodium as an active pharmaceutical ingredient (API).

Finished drug products

The FDA updates the NDC directory daily. The NDC numbers for Piperacillin Sodium API and other APIs are published in this directory by the FDA.

Unfinished drugs

The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.

Pharmaceutical companies that manufacture Piperacillin Sodium as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.

Compounded drug products

The NDC directory also contains data on finished compounded human drug products that contain Piperacillin Sodium and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a Piperacillin Sodium NDC to their finished compounded human drug products, they may choose to do so.

click here to find a list of Piperacillin Sodium suppliers with NDC on PharmaCompass.

Piperacillin Sodium GMP

Piperacillin Sodium Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.

GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).

PharmaCompass offers a list of Piperacillin Sodium GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right Piperacillin Sodium GMP manufacturer or Piperacillin Sodium GMP API supplier for your needs.

Piperacillin Sodium CoA

A Piperacillin Sodium CoA (Certificate of Analysis) is a formal document that attests to Piperacillin Sodium's compliance with Piperacillin Sodium specifications and serves as a tool for batch-level quality control.

Piperacillin Sodium CoA mostly includes findings from lab analyses of a specific batch. For each Piperacillin Sodium CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.

Piperacillin Sodium may be tested according to a variety of international standards, such as European Pharmacopoeia (Piperacillin Sodium EP), Piperacillin Sodium JP (Japanese Pharmacopeia) and the US Pharmacopoeia (Piperacillin Sodium USP).

Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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