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CHEMISTRY
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ACTIVE PHARMA INGREDIENTS

5 API Suppliers, 1 USDMF, 4 Listed Suppliers, $ API Reference Price

5 API Suppliers
1 USDMF
4 Listed Suppliers
$ API Reference Price

FINISHED DOSAGE FORMULATIONS

4 FDF Dossiers, 4 Listed Dossiers

4 FDF Dossiers
4 Listed Dossiers

DIGITAL CONTENT

8 NEWS #PharmaBuzz

media
8 NEWS #PharmaBuzz

MARKET PLACE

3 APIs, 1 FDF Dossiers, 4 EXCIPIENTS

marketPlace
3 APIs
1 FDF Dossiers
4 EXCIPIENTS

Synopsis

ACTIVE PHARMA INGREDIENTS

API Suppliers

USDMF

CEP/COS

JDMF

EU WC

KDMF

NDC API

VMF

Listed Suppliers

API REF. PRICE (USD/KG)

$ 300

MARKET PLACE

API

FDF

0INTERMEDIATES

FINISHED DOSAGE FORMULATIONS

FDF Dossiers

FDA Orange Book

Europe

Canada

Australia

South Africa

Listed Dossiers

0 DRUGS IN DEVELOPMENT

DRUG PRODUCT COMPOSITIONS

REF. STANDARDS OR IMPURITIES

EDQM

USP

Others

PATENTS & EXCLUSIVITIES

US Patents

US Exclusivities

Health Canada Patents

DIGITAL CONTENT

Data Compilation #PharmaFlow

Stock Recap #PipelineProspector

Weekly News Recap #Phispers

News #PharmaBuzz

GLOBAL SALES INFORMATION

US Medicaid (USD)

Annual Reports (USD Million)

Finished Drug Prices

0RELATED EXCIPIENT COMPANIES

0EXCIPIENTS BY APPLICATIONS

Chemistry

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Also known as: Hpmc, Hydroxy propyl methyl cellulose, (hydroxypropyl)methyl cellulose

Molecular Formula

C₅₆H₁₀₈O₃₀

Molecular Weight

1261.4 g/mol

InChI Key

PUSNGFYSTWMJSK-GSZQVNRLSA-N

Polymeric compounds that contain repeating units of hydroxypropyl methylcellulose. The properties of hypromellose polymers can vary greatly and are defined by their molecular weight, the percentage of hydroxyl groups, the percentage of hydroxypropyl groups, and viscosity measurements. They are found a broad variety of commercial products such as FOOD ADDITIVES; EXCIPIENTS; and LUBRICANTS.

1 2D Structure

Hydroxy Propyl Methyl Cellulose

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

(2R,3R,4S,5R,6R)-2,3,4-trimethoxy-6-(methoxymethyl)-5-[(2S,3R,4S,5R,6R)-3,4,5-trimethoxy-6-(methoxymethyl)oxan-2-yl]oxyoxane;1-[[(2R,3R,4S,5R,6S)-3,4,5-tris(2-hydroxypropoxy)-6-[(2R,3R,4S,5R,6R)-4,5,6-tris(2-hydroxypropoxy)-2-(2-hydroxypropoxymethyl)oxan-3-yl]oxyoxan-2-yl]methoxy]propan-2-ol

2.1.2 InChI

InChI=1S/C36H70O19.C20H38O11/c1-19(37)9-45-17-27-29(47-11-21(3)39)31(48-12-22(4)40)34(51-15-25(7)43)36(54-27)55-30-28(18-46-10-20(2)38)53-35(52-16-26(8)44)33(50-14-24(6)42)32(30)49-13-23(5)41;1-21-9-11-13(23-3)15(24-4)18(27-7)20(30-11)31-14-12(10-22-2)29-19(28-8)17(26-6)16(14)25-5/h19-44H,9-18H2,1-8H3;11-20H,9-10H2,1-8H3/t19?,20?,21?,22?,23?,24?,25?,26?,27-,28-,29-,30-,31+,32+,33-,34-,35-,36+;11-,12-,13-,14-,15+,16+,17-,18-,19-,20+/m11/s1

2.1.3 InChI Key

PUSNGFYSTWMJSK-GSZQVNRLSA-N

2.1.4 Canonical SMILES

CC(COCC1C(C(C(C(O1)OC2C(OC(C(C2OCC(C)O)OCC(C)O)OCC(C)O)COCC(C)O)OCC(C)O)OCC(C)O)OCC(C)O)O.COCC1C(C(C(C(O1)OC2C(OC(C(C2OC)OC)OC)COC)OC)OC)OC

2.1.5 Isomeric SMILES

CC(COC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2OCC(C)O)OCC(C)O)OCC(C)O)COCC(C)O)OCC(C)O)OCC(C)O)OCC(C)O)O.COC[C@@H]1[C@H]([C@@H]([C@H]([C@@H](O1)O[C@@H]2[C@H](O[C@H]([C@@H]([C@H]2OC)OC)OC)COC)OC)OC)OC

2.2 Synonyms

2.2.1 MeSH Synonyms

1. Derivative, Hypromellose

2. Derivatives, Hypromellose

3. Hpmc 2910

4. Hpmc K 100 M

5. Hpmc-k-100 M

6. Hpmck100 M

7. Hydroxypropyl Methylcellulose

8. Hypromellose

9. Hypromellose Derivative

10. Hypromellose Derivatives

11. K 8515

12. K-8515

13. K8515

14. Methocel E

15. Methoxyhydroxypropylcellulose

16. Methyl Hydroxypropyl Cellulose

17. Methyl-hydroxypropyl-cellulose

18. Mhpc Polymer

2.2.2 Depositor-Supplied Synonyms

1. Hpmc

2. Hydroxy Propyl Methyl Cellulose

3. (hydroxypropyl)methyl Cellulose

2.3 Create Date

2012-08-08

3 Chemical and Physical Properties

Molecular Formula	C₅₆H₁₀₈O₃₀
Molecular Weight	1261.4 g/mol
Hydrogen Bond Donor Count	8
Hydrogen Bond Acceptor Count	30
Rotatable Bond Count	40
Exact Mass	1260.69254202 g/mol
Monoisotopic Mass	1260.69254202 g/mol
Topological Polar Surface Area	365 Å²
Heavy Atom Count	86
Formal Charge	0
Complexity	1480
Isotope Atom Count	0
Defined Atom Stereocenter Count	20
Undefined Atom Stereocenter Count	8
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2