ITIS Plus Care Eye Drops is designed to keep eyes well-lubricated, nourished, healthy and sparkling. This ophthalmic topical preparation is first-of-its-kind artificial tear drops. ITIS Plus Care Eye Drops is a sterile, isotonic Hydroxy Propyl Methyl Cellulose (HPMC) 0.3%, containing poly-herbal formulation to be used as therapeutic eye lubricant. It is designed to protect against eye strain and tear film loss by keeping eyes moist and nourished.
The aim of the present investigation was to prepare and optimize suitable combination of polymers hydroxypropyl methylcellulose (HPMC) and pluronic® F127 (PN F127) for the development of thermosensitive gel of Metoprolol succinate (MS) using central composite design (CCD). The effect of formulation factors (concentration of HPMC and PN F127) on responses such as cumulative percentage release (CPR) of MS, bioadhesive force (BF) and viscosity was measured statistically. Quadratic model was found to be best fit model among different models used in the study. The optimum conditions were found to be 0.92% of HPMC and 15% of PN F127. Under these conditions, the predicted CPR, BF and viscosity were found to be 84.94 ?g/cm2, 41.56 gf and 48.94 Pa s, respectively. Ex vivo permeation of MS from optimized thermosensitive gel across abdominal skin of rat demonstrated highest flux (64.35 ?g/cm2/h) for the gel formulation containing 1,8-cineole (5% w/w). The hypotensive activity was performed on normotensive rabbits and the results showed that the optimized formulation prolonged the activity up to 12 h. The above findings indicated that thermosensitive gel of MS for skin application exhibited strong potential against hypertension and expected to provide a better alternative to oral MS formulations.
Oral disintegrating film represents an optimal alternative for delivery system of active compounds. The choice of film-forming polymer is the first step in the development of oral disintegrating films and the knowledge of molecular interactions in this matrix is fundamental to advance in this area. Therefore, this study aimed to characterize gelatin and hydroxypropyl methylcellulose (HPMC) films and their blends as matrices of oral disintegrating films. The films were produced by casting technique and were characterized by scanning electron microscopy, Fourier transform infrared spectroscopy, differential scanning calorimetry, mechanical properties, contact angle, time disintegration and bioadhesive strength. Differential scanning calorimetry showed that enthalpy of fusion and melting temperatures of the blends films were lower than those of the gelatin film, which may be associated with the lack of intra-chain interactions also observed in the Fourier transform infrared spectra.In blends, a less compact cross-section structure was observed in scanning electron microscopy images compared with isolated polymer films.
Smoking cessation is of current topical interest due to the significant negative health and economic impact in many countries. This study aimed to develop buccal films and wafers comprising HPMC and sodium alginate (SA) for potential use in nicotine replacement therapy via the buccal mucosa, as a cheap but effective alternative to currently used nicotine patch and chewing gum.
To study the effect of hydrophobic modification of the emulsifier on the relationship between emulsion stability and polymer emulsifier concentration, silicone oil emulsions were prepared using by hydroxypropyl methylcellulose (original HPMC) and HPMC stearoxy ether (hydrophobic HPMC) at concentrations around their overlap concentrations. Both HPMC types completely emulsified the silicone oil. However, the volume fraction of silicone oil in the emulsion prepared using hydrophobic HPMC was less than that that by the original HPMC, and the average oil droplet size in the former emulsion was less than that in the latter emulsion. Increasing HPMC concentration led to increase in both the amount of adsorbed polymer emulsifier and the storage moduli in the linear region, irrespective of which HPMC was used.
Fast dissolving oral film of Losartan potassium were prepared and evaluated with an objective to rapid dissolution of drug and absorption which may produce the rapid onset of action in the treatment of hypertension and provides the convenient means of administration to those patient suffering from difficulty in swallowing such as paediatrics, geriatric, and uncooperative mentally ill patients and also improve the bioavailability of the drug. The fast dissolving oral film were prepared using different polymers like polyvinyl alcohol, polyvinyl pyrollidone, hydroxyl propyl methyl cellulose, carbopol, pectin and tragacanth by solvent casting method. The fast dissolving oral film evaluated for folding endurance, swelling index, surface pH, in vitro disintegration time, drug content, drug polymer compatibility (IR Study), and in vitro drug release. The physical appearance and folding endurance properties were found to be good and electron microscopy shows that films are clear, colourless with smooth surface without any scratches.The average folding endurance time within the range of 112 to 208. The drug content showed uniform mixing of drug in all prepared fast dissolving films. The in vitro drug release showed 78 to 96 % drug release within 5 minutes. Drug release obeys the first order kinetics. The prepared films were stable. Hence it can be inferred that the fast dissolving oral film of Losartan potassium may produce the rapid acti
Microspheres of meclozine hydrochloride (MCZ HCl) were formulated in order to prolong the residence time at the absorption site by intimate contact with the mucous membrane. The microspheres were prepared by oriface-ionotropic gelation method using bioadhesive polymers such as xanthan, sodium, carboxy methyl cellulose (Na- CMC) and hydroxy propyl methylcellulose (HPMC k15) in combination with different ratio of sodium alginate. Totally nine different formulations of MCZ HCl were prepared by using the above polymers. The microspheres were evaluated for percentage yield, entrapment efficiency, particle size analysis, surface morphology (scanning electron microscopy), differential scanning calorimetry (DSC), swelling index, drug content and in-vitro dissolution study. The relative bioavailability of the optimized microspheres was compared with commercially available product after oral administration on healthy human volunteers using a randomized, cross-over design.
Amneal`s Generic Milnacipran Hydrochloride approved in US for Fibromyalgia