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Chemistry

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Also known as: 91503-79-6, Ropion, Lfp 83, Fp 83, Fp-83, I0ou31pui5
Molecular Formula
C19H19FO4
Molecular Weight
330.3  g/mol
InChI Key
ALIVXCSEERJYHU-UHFFFAOYSA-N
FDA UNII
I0OU31PUI5

Flurbiprofen Axetil
an analgesic
1 2D Structure

Flurbiprofen Axetil

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
1-acetyloxyethyl 2-(3-fluoro-4-phenylphenyl)propanoate
2.1.2 InChI
InChI=1S/C19H19FO4/c1-12(19(22)24-14(3)23-13(2)21)16-9-10-17(18(20)11-16)15-7-5-4-6-8-15/h4-12,14H,1-3H3
2.1.3 InChI Key
ALIVXCSEERJYHU-UHFFFAOYSA-N
2.2 Other Identifiers
2.2.1 UNII
I0OU31PUI5
2.3 Synonyms
2.3.1 MeSH Synonyms

1. Fp 83

2. Fp-83

3. Fp83

2.3.2 Depositor-Supplied Synonyms

1. 91503-79-6

2. Ropion

3. Lfp 83

4. Fp 83

5. Fp-83

6. I0ou31pui5

7. Lfp-83

8. Dtxsid8048600

9. Fp83

10. Dtxcid1028526

11. (1,1'-biphenyl)-4-acetic Acid, 2-fluoro-alpha-methyl-, 1-(acetyloxy)ethyl Ester

12. Refchem:141041

13. 1-(acetyloxy)ethyl 2-(2-fluoro-(1,1'-biphenyl)-4-yl)propanoate

14. 1-acetoxyethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate

15. 1-acetyloxyethyl 2-(3-fluoro-4-phenylphenyl)propanoate

16. 1-acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate

17. Mfcd00900049

18. Lipfen

19. Lfp 83;ropiopn;lfp-83;lfp83

20. Flurbiprofen Axetil (jan)

21. Flurbiprofen Axetil [jan]

22. Lipo-flurbiprofen Axetil

23. Liposomal Flurbiprofen Axetil

24. Cas-91503-79-6

25. C19h19fo4

26. Unii-i0ou31pui5

27. Lfp83

28. Ncgc00182710-01

29. Ncgc00182710-02

30. 2-fluoro-a-methyl-[1,1'-biphenyl]-4-acetic Acid 1-(acetyloxy)ethyl Ester; Flurbiprofen Axetil

31. 1-acetoxyethyl-2-(2-fluoro-4-biphenylyl)propionate

32. Ropion (tn)

33. 4-biphenylacetic Acid, 2-fluoro-alpha-methyl-, 1-acetoxyethyl Ester

34. 2-fluoro-alpha-methyl-(1,1'-biphenyl)-4-acetic Acid 1-(acetyloxy)ethyl Ester

35. Orb1304142

36. Schembl1649401

37. Chembl3183067

38. Schembl29370747

39. Chebi:31627

40. Hms5085j04

41. Msk10984

42. Tox21_113023

43. Ac-455

44. Flurbiprofen Axetil [who-dd]

45. S6457

46. Akos024464989

47. Tox21_113023_1

48. Db14938

49. Ds-8257

50. Fa23508

51. Da-33622

52. Hy-101481

53. Cs-0021519

54. F1176

55. D01475

56. F17835

57. Sbi-0654123.0001

58. 1-acetoxyethyl-2-(2-fluoro-4-biphenyl)propionate

59. 1-acetoxyethyl 2-(2-fluoro-4-biphenylyl)propanoate

60. Q27280207

61. 1-(acetyloxy)ethyl 2-(2-fluorobiphenyl-4-yl)propanoate

62. Acetoxyethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate

63. 1-(acetyloxy)ethyl 2-(2-fluoro[1,1'-biphenyl]-4-yl)propanoate

64. 2-fluoro-a-methyl-[1,1'-biphenyl]-4-acetic Acid 1-(acetyloxy)ethyl Ester

65. (1,1'-biphenyl)-4-acetic Acid, 2-fluoro-.alpha.-methyl-, 1-(acetyloxy)ethyl Ester

66. Lfp 83; Ropiopn; 1-acetoxyethyl 2-(2-fluoro-4-biphenylyl)propionate; 1-acetoxyethyl 2-(2-fluoro-[1,1'-biphenyl]-4-yl)propanoate

2.4 Create Date
2005-03-25
3 Chemical and Physical Properties
Molecular Weight 330.3 g/mol
Molecular Formula C19H19FO4
XLogP34.9
Hydrogen Bond Donor Count0
Hydrogen Bond Acceptor Count5
Rotatable Bond Count7
Exact Mass Da
Monoisotopic Mass Da
Topological Polar Surface Area52.6
Heavy Atom Count24
Formal Charge0
Complexity433
Isotope Atom Count0
Defined Atom Stereocenter Count0
Undefined Atom Stereocenter Count2
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count1
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Anti-Inflammatory Agents, Non-Steroidal

Anti-inflammatory agents that are non-steroidal in nature. In addition to anti-inflammatory actions, they have analgesic, antipyretic, and platelet-inhibitory actions. They act by blocking the synthesis of prostaglandins by inhibiting cyclooxygenase, which converts arachidonic acid to cyclic endoperoxides, precursors of prostaglandins. Inhibition of prostaglandin synthesis accounts for their analgesic, antipyretic, and platelet-inhibitory actions; other mechanisms may contribute to their anti-inflammatory effects.


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