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1. Ago 178
2. Ago-178
3. Ago178
4. N-(2-(7-methoxy-1-naphthyl)ethyl)acetamide
5. S 20098
6. S-20098
7. S20098
8. Thymanax
9. Valdoxan
1. 138112-76-2
2. Thymanax
3. Valdoxan
4. N-[2-(7-methoxynaphthalen-1-yl)ethyl]acetamide
5. N-(2-(7-methoxynaphthalen-1-yl)ethyl)acetamide
6. S20098
7. S-20098
8. Agomelatine [inn]
9. Melitor
10. Ago-178
11. S 20098
12. Acetamide, N-[2-(7-methoxy-1-naphthalenyl)ethyl]-
13. N-(2-(7-methoxy-1-naphthyl)ethyl)acetamide
14. N-(2-(7-methoxynaphth-1-yl)ethyl)acetamide
15. N-(2-(7-methoxy-1-naphthalenyl)ethyl)acetamide
16. Chembl10878
17. 137r1n49ad
18. N-[2-(7-methoxy-1-naphthalenyl)ethyl]acetamide
19. Agomelatine (inn)
20. Ncgc00253646-01
21. N-[2-(7-methoxy-1-naphthyl)ethyl]acetamide
22. Acetamide, N-(2-(7-methoxy-1-naphthalenyl)ethyl)-
23. N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide
24. Ago 178
25. Valdoxan (tn)
26. Unii-137r1n49ad
27. Ago178
28. N-[2-(7-methoxynaphth-1-yl)ethyl]acetamide
29. Sr-01000944938
30. Agomelatine [inn:ban]
31. Ago178c
32. Agomelatine-[d4]
33. Awy
34. Agomelatine- Bio-x
35. Mfcd00916659
36. Agomelatine [mi]
37. Agomelatine [mart.]
38. Dsstox_cid_31431
39. Dsstox_rid_97317
40. Dsstox_gsid_57642
41. Agomelatine [who-dd]
42. Gtpl198
43. Mls006011913
44. Schembl114476
45. Agomelatine [ema Epar]
46. Zinc5608
47. Dtxsid3057642
48. Agomelatine, >=98% (hplc)
49. Chebi:134990
50. Bcpp000421
51. Hms3604n09
52. Hms3648g18
53. Hms3654b07
54. Hms3884a07
55. Bcp02084
56. Tox21_113772
57. Bbl029084
58. Bdbm50035179
59. Pdsp1_001305
60. Pdsp1_001784
61. Pdsp2_001289
62. Pdsp2_001767
63. S1243
64. Stl237728
65. Akos005145681
66. Ac-3395
67. Bcp9000250
68. Ccg-221950
69. Cs-0740
70. Db06594
71. Ks-1247
72. Sb19508
73. Ncgc00253646-10
74. Ba167079
75. Hy-17038
76. Smr002530056
77. Am20090763
78. B2262
79. Cas-138112-76-2
80. Ft-0657383
81. Sw219177-1
82. A19445
83. D02578
84. Ab01274769-01
85. Ab01274769_02
86. 112a762
87. L000528
88. Q395229
89. Q-102507
90. Sr-01000944938-1
91. Sr-01000944938-3
92. F0001-2383
93. (4-chlorophenyl)-[(9h-fluoren-9-ylmethoxycarbonylamino)]-aceticacid
94. N-[2-(7-methoxy-naphthalen-1-yl)-ethyl]-acetamide(agomelatine)
Molecular Weight | 243.30 g/mol |
---|---|
Molecular Formula | C15H17NO2 |
XLogP3 | 2.7 |
Hydrogen Bond Donor Count | 1 |
Hydrogen Bond Acceptor Count | 2 |
Rotatable Bond Count | 4 |
Exact Mass | 243.125928785 g/mol |
Monoisotopic Mass | 243.125928785 g/mol |
Topological Polar Surface Area | 38.3 Ų |
Heavy Atom Count | 18 |
Formal Charge | 0 |
Complexity | 280 |
Isotope Atom Count | 0 |
Defined Atom Stereocenter Count | 0 |
Undefined Atom Stereocenter Count | 0 |
Defined Bond Stereocenter Count | 0 |
Undefined Bond Stereocenter Count | 0 |
Covalently Bonded Unit Count | 1 |
Agomelatine is indicated to treat major depressive episodes in adults.
Treatment of major depressive episodes in adults.
Treatment of major depressive episodes in adults.
Treatment of major depressive episodes
Agomelatine resynchronises circadian rhythms in animal models of delayed sleep phase syndrome and other circadian rhythm disruptions. It increases noradrenaline and dopamine release specifically in the frontal cortex and has no influence on the extracellular levels of serotonin. Agomelatine has shown an antidepressant-like effect in animal depression models, (learned helplessness test, despair test, and chronic mild stress) circadian rhythm desynchronisation, and in stress and anxiety models. In humans, agomelatine has positive phase shifting properties; it induces a phase advance of sleep, body temperature decline and melatonin onset. Controlled studies in humans have shown that agomelatine is as effective as the SSRI antidepressants paroxetine and sertraline in the treatment of major depression
Hypnotics and Sedatives
Drugs used to induce drowsiness or sleep or to reduce psychological excitement or anxiety. (See all compounds classified as Hypnotics and Sedatives.)
N06AX22
N06AX22
N06AX22
S76 | LUXPHARMA | Pharmaceuticals Marketed in Luxembourg | Pharmaceuticals marketed in Luxembourg, as published by d'Gesondheetskeess (CNS, la caisse nationale de sante, www.cns.lu), mapped by name to structures using CompTox by R. Singh et al. (in prep.). List downloaded from https://cns.public.lu/en/legislations/textes-coordonnes/liste-med-comm.html. Dataset DOI:10.5281/zenodo.4587355
N - Nervous system
N06 - Psychoanaleptics
N06A - Antidepressants
N06AX - Other antidepressants
N06AX22 - Agomelatine
Absorption
Bioavailability is less than 5%.
Hepatic (90% CYP1A2 and 10% CYP2C9).
<2 hours
The novel antidepressant agent, agomelatine, behaves as an agonist at melatonin receptors (MT1 and MT2) and as an antagonist at serotonin (5-HT)(2C) receptors.
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PharmaCompass offers a list of Agomelatine API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Agomelatine manufacturer or Agomelatine supplier for your needs.
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PharmaCompass also assists you with knowing the Agomelatine API Price utilized in the formulation of products. Agomelatine API Price is not always fixed or binding as the Agomelatine Price is obtained through a variety of data sources. The Agomelatine Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.
A DSSTox_CID_31431 manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of DSSTox_CID_31431, including repackagers and relabelers. The FDA regulates DSSTox_CID_31431 manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. DSSTox_CID_31431 API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.
click here to find a list of DSSTox_CID_31431 manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.
A DSSTox_CID_31431 supplier is an individual or a company that provides DSSTox_CID_31431 active pharmaceutical ingredient (API) or DSSTox_CID_31431 finished formulations upon request. The DSSTox_CID_31431 suppliers may include DSSTox_CID_31431 API manufacturers, exporters, distributors and traders.
click here to find a list of DSSTox_CID_31431 suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.
A DSSTox_CID_31431 DMF (Drug Master File) is a document detailing the whole manufacturing process of DSSTox_CID_31431 active pharmaceutical ingredient (API) in detail. Different forms of DSSTox_CID_31431 DMFs exist exist since differing nations have different regulations, such as DSSTox_CID_31431 USDMF, ASMF (EDMF), JDMF, CDMF, etc.
A DSSTox_CID_31431 DMF submitted to regulatory agencies in the US is known as a USDMF. DSSTox_CID_31431 USDMF includes data on DSSTox_CID_31431's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The DSSTox_CID_31431 USDMF is kept confidential to protect the manufacturer’s intellectual property.
click here to find a list of DSSTox_CID_31431 suppliers with USDMF on PharmaCompass.
In Korea, the Ministry of Food and Drug Safety (MFDS) is in charge of regulating pharmaceutical products and services.
Pharmaceutical companies submit a DSSTox_CID_31431 Drug Master File in Korea (DSSTox_CID_31431 KDMF) to the MFDS, which includes comprehensive information about the production, processing, facilities, materials, packaging, and testing of DSSTox_CID_31431. The MFDS reviews the DSSTox_CID_31431 KDMF as part of the drug registration process and uses the information provided in the DSSTox_CID_31431 KDMF to evaluate the safety and efficacy of the drug.
After submitting a DSSTox_CID_31431 KDMF to the MFDS, the registered manufacturer can provide importers or distributors with the registration number without revealing confidential information to Korean business partners. Applicants seeking to register their DSSTox_CID_31431 API can apply through the Korea Drug Master File (KDMF).
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A DSSTox_CID_31431 written confirmation (DSSTox_CID_31431 WC) is an official document issued by a regulatory agency to a DSSTox_CID_31431 manufacturer, verifying that the manufacturing facility of a DSSTox_CID_31431 active pharmaceutical ingredient (API) adheres to the Good Manufacturing Practices (GMP) regulations of the importing country. When exporting DSSTox_CID_31431 APIs or DSSTox_CID_31431 finished pharmaceutical products to another nation, regulatory agencies frequently require a DSSTox_CID_31431 WC (written confirmation) as part of the regulatory process.
click here to find a list of DSSTox_CID_31431 suppliers with Written Confirmation (WC) on PharmaCompass.
National Drug Code is a comprehensive database maintained by the FDA that contains information on all drugs marketed in the US. This directory includes information about finished drug products, unfinished drug products, and compounded drug products, including those containing DSSTox_CID_31431 as an active pharmaceutical ingredient (API).
The FDA updates the NDC directory daily. The NDC numbers for DSSTox_CID_31431 API and other APIs are published in this directory by the FDA.
The NDC unfinished drugs database includes product listing information submitted for all unfinished drugs, such as active pharmaceutical ingredients (APIs), drugs intended for further processing and bulk drug substances for compounding.
Pharmaceutical companies that manufacture DSSTox_CID_31431 as an active pharmaceutical ingredient (API) must furnish the FDA with an updated record of all drugs that they produce, prepare, propagate, compound, or process for commercial distribution in the US at their facilities.
The NDC directory also contains data on finished compounded human drug products that contain DSSTox_CID_31431 and are produced by outsourcing facilities. While these outsourcing facilities are not mandated to assign a DSSTox_CID_31431 NDC to their finished compounded human drug products, they may choose to do so.
click here to find a list of DSSTox_CID_31431 suppliers with NDC on PharmaCompass.
DSSTox_CID_31431 Active pharmaceutical ingredient (API) is produced in GMP-certified manufacturing facility.
GMP stands for Good Manufacturing Practices, which is a system used in the pharmaceutical industry to make sure that goods are regularly produced and monitored in accordance with quality standards. The FDA’s current Good Manufacturing Practices requirements are referred to as cGMP or current GMP which indicates that the company follows the most recent GMP specifications. The World Health Organization (WHO) has its own set of GMP guidelines, called the WHO GMP. Different countries can also set their own guidelines for GMP like China (Chinese GMP) or the EU (EU GMP).
PharmaCompass offers a list of DSSTox_CID_31431 GMP manufacturers, exporters & distributors, which can be sorted by USDMF, JDMF, KDMF, CEP (COS), WC, API price, and more, enabling you to easily find the right DSSTox_CID_31431 GMP manufacturer or DSSTox_CID_31431 GMP API supplier for your needs.
A DSSTox_CID_31431 CoA (Certificate of Analysis) is a formal document that attests to DSSTox_CID_31431's compliance with DSSTox_CID_31431 specifications and serves as a tool for batch-level quality control.
DSSTox_CID_31431 CoA mostly includes findings from lab analyses of a specific batch. For each DSSTox_CID_31431 CoA document that a company creates, the USFDA specifies specific requirements, such as supplier information, material identification, transportation data, evidence of conformity and signature data.
DSSTox_CID_31431 may be tested according to a variety of international standards, such as European Pharmacopoeia (DSSTox_CID_31431 EP), DSSTox_CID_31431 JP (Japanese Pharmacopeia) and the US Pharmacopoeia (DSSTox_CID_31431 USP).