List of Suppliers' Chewable Orodispersible Aids Excipients Application used in Calcium Folinate on PharmaCompass.com

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Also known as: Calcium folinate, Calcium citrovorum factor, Folinic acid calcium salt, Folinic acid-sf, calcium salt, (+)-l-folinic acid, calcium salt, 1492-18-8
Molecular Formula
C20H23CaN7O7+2
Molecular Weight
513.5  g/mol
InChI Key
KVUAALJSMIVURS-ZEDZUCNESA-N

Calcium Folinate
The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.
1 2D Structure

Calcium Folinate

2 Identification
2.1 Computed Descriptors
2.1.1 IUPAC Name
calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid
2.1.2 InChI
InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/t12?,13-;/m0./s1
2.1.3 InChI Key
KVUAALJSMIVURS-ZEDZUCNESA-N
2.1.4 Canonical SMILES
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O.[Ca+2]
2.1.5 Isomeric SMILES
C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.[Ca+2]
2.2 Synonyms
2.2.1 MeSH Synonyms

1. 5 Formyltetrahydrofolate

2. 5 Formyltetrahydropteroylglutamate

3. 5-formyltetrahydrofolate

4. 5-formyltetrahydropteroylglutamate

5. Acid, Folinic

6. Calcium Folinate

7. Citrovorum Factor

8. Factor, Citrovorum

9. Folinate, Calcium

10. Folinic Acid

11. Folinic Acid Sf

12. Folinic Acid-sf

13. Leucovorin

14. Leucovorin, (d)-isomer

15. Leucovorin, (dl)-isomer

16. Leucovorin, (r)-isomer

17. Leucovorin, Calcium

18. Leucovorin, Calcium (1:1) Salt

19. Leucovorin, Calcium (1:1) Salt, (dl)-isomer

20. Leucovorin, Calcium (1:1) Salt, Pentahydrate

21. Leucovorin, Monosodium Salt

22. Leukovorin

23. Leukovorum

24. Monosodium Salt Leucovorin

25. N(5)-formyltetrahydrofolate

26. Wellcovorin

2.2.2 Depositor-Supplied Synonyms

1. Calcium Folinate

2. Calcium Citrovorum Factor

3. Folinic Acid Calcium Salt

4. Folinic Acid-sf, Calcium Salt

5. (+)-l-folinic Acid, Calcium Salt

6. 1492-18-8

7. Nsc3590

8. Sr-05000001662

9. Pharmakon1600-01500364

10. Nsc757083

11. Nsc-757083

12. Sr-05000001662-1

13. Sr-05000001662-2

14. Glutamic Acid,6,7,8-tetrahydro-4-hydroxy-6- Pteridinyl)methyl]amino]benzoyl]-, Calcium Salt (1:1), L-

15. L-glutamic Acid,4,5,6,7,8-hexahydro-4-oxo-6- Pteridinyl)methyl]amino]benzoyl]-, Calcium Salt (1:1), (s)-

2.3 Create Date
2019-01-15
3 Chemical and Physical Properties
Molecular Weight 513.5 g/mol
Molecular Formula C20H23CaN7O7+2
Hydrogen Bond Donor Count7
Hydrogen Bond Acceptor Count10
Rotatable Bond Count9
Exact Mass513.1284869 g/mol
Monoisotopic Mass513.1284869 g/mol
Topological Polar Surface Area216 Ų
Heavy Atom Count35
Formal Charge2
Complexity911
Isotope Atom Count0
Defined Atom Stereocenter Count1
Undefined Atom Stereocenter Count1
Defined Bond Stereocenter Count0
Undefined Bond Stereocenter Count0
Covalently Bonded Unit Count2
4 Pharmacology and Biochemistry
4.1 MeSH Pharmacological Classification

Antidotes

Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)


Vitamin B Complex

A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)


4.2 ATC Code

V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AF - Detoxifying agents for antineoplastic treatment

V03AF03 - Calcium folinate


API SUPPLIERS

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USDMF

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26th North American ISSX
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02

Cerbios Pharma Sa

Switzerland

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02

Cerbios Pharma Sa

Switzerland
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GDUFA

DMF Review : Complete

Rev. Date : 2013-10-04

Pay. Date : 2013-09-25

DMF Number : 5046

Submission : 1983-06-30

Status : Active

Type : II

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Gmt Fine Chemicals Sa

Switzerland

USDMF

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03

Gmt Fine Chemicals Sa

Switzerland
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GDUFA

DMF Review : Complete

Rev. Date : 2019-08-16

Pay. Date : 2019-06-24

DMF Number : 33740

Submission : 2019-05-18

Status : Active

Type : II

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Gmt Fine Chemcals Sa

Switzerland

USDMF

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04

Gmt Fine Chemcals Sa

Switzerland
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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 16718

Submission : 2003-07-18

Status : Inactive

Type : II

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GDUFA

DMF Review : Complete

Rev. Date : 2024-07-26

Pay. Date : 2024-06-10

DMF Number : 38878

Submission : 2023-09-27

Status : Active

Type : II

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Merck And Cie Kmg

Switzerland

USDMF

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06

Merck And Cie Kmg

Switzerland
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GDUFA

DMF Review : Complete

Rev. Date : 2018-03-02

Pay. Date : 2018-02-20

DMF Number : 5261

Submission : 1984-01-23

Status : Active

Type : II

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Labochim Spa

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USDMF

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07

Labochim Spa

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 10232

Submission : 1993-03-06

Status : Inactive

Type : II

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Monsanto Co

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USDMF

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08

Monsanto Co

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 5429

Submission : 1984-07-09

Status : Inactive

Type : II

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Cyanamid Gmbh

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09

Cyanamid Gmbh

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GDUFA

DMF Review : N/A

Rev. Date :

Pay. Date :

DMF Number : 3715

Submission : 1980-02-11

Status : Inactive

Type : II

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CEP/COS

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Certificate Number : CEP 2004-009 - Rev 04

Status : Valid

Issue Date : 2024-04-15

Type : Chemical

Substance Number : 978

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Certificate Number : R1-CEP 2011-370 - Rev 00

Status : Valid

Issue Date : 2019-07-26

Type : Chemical

Substance Number : 978

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Certificate Number : R1-CEP 1996-055 - Rev 08

Status : Valid

Issue Date : 2023-05-19

Type : Chemical

Substance Number : 978

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Cerbios-Pharma SA Barbengo CH

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CEP 1997-051 - Rev 10
Valid
Chemical
2024-03-06
978
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Cerbios-Pharma SA Barbengo CH

Gabon
26th North American ISSX
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Cerbios-Pharma SA Barbengo CH

Gabon
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Certificate Number : CEP 1997-051 - Rev 10

Status : Valid

Issue Date : 2024-03-06

Type : Chemical

Substance Number : 978

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Cerbios-Pharma SA Barbengo CH

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CEP 2013-176 - Rev 02
Valid
Chemical
2024-04-02
978
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Cerbios-Pharma SA Barbengo CH

Gabon
26th North American ISSX
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Cerbios-Pharma SA Barbengo CH

Gabon
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Certificate Number : CEP 2013-176 - Rev 02

Status : Valid

Issue Date : 2024-04-02

Type : Chemical

Substance Number : 978

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EU WC

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Calcium Folinate IP/EP/USP

Date of Issue : 2022-06-17

Valid Till : 2025-07-07

Written Confirmation Number : WC-0104

Address of the Firm : #125 & 126, Sipcot Industrial Complex, Hosur-635 126, Tamilnadu

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Listed Suppliers

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  • fda
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Virtual BoothRochem, your partner in developing, sourcing, and supplying pharmaceutical & animal health ingredients of Chinese origin.

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Calcium Folinate

About the Company : Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quali...

Established in 1994, Rochem is a distributor of pharmaceutical, food, nutritional and animal health ingredients to some of the largest companies in the world. It sources high-quality ingredients manufactured in China. Headquartered in the Hauppauge, New York, Rochem has 16 offices spread across the globe to cater to the needs of its customers. Rochem’s operations are fully cGMP compliant and has been audited by the USFDA as well as several multinational organizations. It also trains and audits its partners to ensure all of their technologies and systems are FDA-compliant.
Rochem

02

Allastir

India
26th North American ISSX
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Allastir

India
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Leucovorin Calcium

About the Company : Allastir instituted the services in 2010 with a motive to cater the pharmaceutical industry with niche API's. In Allastir we strongly believe in team work and customer satisfaction...

Allastir instituted the services in 2010 with a motive to cater the pharmaceutical industry with niche API's. In Allastir we strongly believe in team work and customer satisfaction. Allastir is backed by the strong R&D team who are passionate about what they do. We manufacture niche API's with high quality which are suitable for formulations like tablets, capsules, soft gelatins and oral liquids.To be the larder to develop innovative niche molecule to the health care industry for the betterment of human life.Our Vision is to be the Number ONE company in Health care Industry in the World.
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Calcium Folinate

About the Company : Anthem Biosciences is a leading contract research and innovation service provider (CRISP) in Bengaluru, India, which manufactures novel drug actives. Established in 2007, it specia...

Anthem Biosciences is a leading contract research and innovation service provider (CRISP) in Bengaluru, India, which manufactures novel drug actives. Established in 2007, it specializes in both biological and chemistry-based products and services. It has a strong track record in drug and product development, and supports development, optimization and testing of various compounds including proteins, monoclonal antibodies, peptides, large & small molecules and toxins. Inspected by USFDA, Japan’s PMDA, EU QPs, it develops nutritional products using organic synthesis and offers quality control and regulatory compliance assistance to clients.
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Cerbios-Pharma SA

Switzerland
26th North American ISSX
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Cerbios-Pharma SA

Switzerland
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Calcium Folinate

About the Company : Cerbios is a privately held company located in Lugano, Switzerland. Cerbios is the ideal CDMO partner from clinical to commercial supply of ADCs, HPAPIs, Proteins and Antibodies. ...

Cerbios is a privately held company located in Lugano, Switzerland. Cerbios is the ideal CDMO partner from clinical to commercial supply of ADCs, HPAPIs, Proteins and Antibodies. Services offered include Process & Analytical Development, Scale-up and Clinical Supply, Industrial Validation, Commercial Supply and Full CMC Regulatory Support. Cerbios supplies also generic APIs primarily used in Oncology, Respiratory and Dermatology. Cerbios has additionally a 40 years’ experience in the probiotics field: the portfolio includes a FDF based on proprietary strain SF68® for treatment of diarrhea & dysbiosis, ACNE & Seborrheic dermatitis.
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DEAFARMA

Italy
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DEAFARMA

Italy
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Calcium Folinate

About the Company : In the dinamic pharmaceutical field, DEAFARMA is the reference point for primaries Pharmaceutical Laboratories for over twenty years, even in the national and international territo...

In the dinamic pharmaceutical field, DEAFARMA is the reference point for primaries Pharmaceutical Laboratories for over twenty years, even in the national and international territory. DEAFARMA works with success in the pharmaceutical raw materials field through Agencies and professional relations with the most important European and Asiatic factories. Our partners are well known, reliable producers and all of them are operating in accordance with the latest GMP Rules. The APIs mentioned in the DEAFARMA catalogue are always supported by DMF and/or CEP.
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Leucovorin Calcium

About the Company : As an EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979 as Calcium Ind...

As an EU-GMP certified global company and an established hallmark for pharmaceutical standards, Global Calcium has stood the test of time since its inception in 1979 as Calcium India. Today, Global Calcium represents the true hallmark of quality when it comes to pharmaceutical products. Global Calcium is backed by an excellent management team comprising of industry specialists, technocrats, entrepreneurs and business specialists bringing in strong domain expertise in fields such as investment banking, to consulting to behind the scenes pure sciences.
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Calcium Folinate

About the Company : HENGDIAN GROUP was established in 1975, till now it has become a transnational,conglomerate group and been one of the largest private-owned enterprises in China. The Pharmaceutical...

HENGDIAN GROUP was established in 1975, till now it has become a transnational,conglomerate group and been one of the largest private-owned enterprises in China. The Pharmaceutical & Chemical division has 3 sub-companies with over 3,000 employees of which over 30% are technicians; This division is mainly producing APIs, Agrochemical and Dyestuffs with related intermediates as well as other special chemicals. The group also focuses on CONTRACT MANUFACTURE service under GMP and confidential agreement with our clients.
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Leucovorin

About the Company : Established in the year 2004, Sakar is engaged in manufacturing of Pharmaceutical products providing Liquid Orals, Cephalosporin Tablet, Capsule, Dry Powder Syrup, Dry Powder Injec...

Established in the year 2004, Sakar is engaged in manufacturing of Pharmaceutical products providing Liquid Orals, Cephalosporin Tablet, Capsule, Dry Powder Syrup, Dry Powder Injections, Liquid Injectables (SVP) in Ampoules and Vials & Lyophilized Injections. Sakar is managed by a team of professionals with an endeavour to offer Quality Pharmaceutical & Health Care Products in various countries. The company operates as contract development and manufacturing organisation (CDMO), being the EU GMP approved CMO for leading multinational pharmaceutical companies.
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LEUCOVORIN CALCIUM

About the Company : Shouyuan chemical (one of the leading chemicals supplier in China) specializes in manufacturing, supplying, and custom synsthesis latest chemicals. Our products cover all kinds of ...

Shouyuan chemical (one of the leading chemicals supplier in China) specializes in manufacturing, supplying, and custom synsthesis latest chemicals. Our products cover all kinds of range like pharmaceuticals, agrochemicals, electronic chemicals, surfactants and other specialty chemicals.
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Calcium Folinate

About the Company : Huiyu Pharma, established in Oct. 2010, is a specialized pharmaceutical company focusing on developing and manufacturing high-quality oncology products. At present, products in our...

Huiyu Pharma, established in Oct. 2010, is a specialized pharmaceutical company focusing on developing and manufacturing high-quality oncology products. At present, products in our list include the following:Azacitidine, Bendamustine HCl, Bortezomib, Camptothecin, Carboplatin, Decitabine, Docetaxel, Doxorubicin HCl, Epirubicin HCl, Gemcitabine Hydrochloride, Irinotecan Hydrochloride, Methotrexate, Oxaliplatin, Paclitaxel, Pemetrexed disodium...We welcome those traders, distributors, and wholesalers who are interested in our products.
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API Reference Price

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03-Apr-2021
20-Jul-2024
KGS
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