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Technical details about Calcium Folinate, learn more about the structure, uses, toxicity, action, side effects and more

Calcium Folinate

Synopsis, Chemistry

APIs // Active Pharmaceutical Ingredients

20 Suppliers, 9 USDMF, 4 CEP/COS, 3 JDMF, 1 EU WC, 2 KDMF, 20 NDC API, 11 Listed Suppliers

DEVELOPMENTS

60 Drug(s) in Development

60 Drug(s) in Development

PRICE INFORMATION

API Reference Price, API Exports, API Imports, FDF Imports

INTERMEDIATES

1 Suppliers

1 Suppliers

DOSSIERs // Finished Dosage Forms

177 Dossiers, 82 FDA Orange Book, 51 Europe, 6 Australia, 6 South Africa, 32 Listed Dossiers

RELATED EXCIPIENT COMPANIES

Suppliers, 31 Kerry, 20 BASF, 18 Roquette, 13 Microlex e.U, 11 Sigachi Industries, 10 Corel Pharma Chem, 9 Actylis, 8 Gangwal Chemicals, 8 Gangwal Healthcare, 8 Anhui Sunhere Pharmaceutical Excipients Co.,Ltd, 7 Seppic, 7 Ideal Cures Pvt Ltd, 6 Lonza Capsugel, 5 DFE Pharma, 5 Shanghai Shenmei Pharmaceutical Technology Co., Ltd, 4 SPI Pharma, 4 ACG Worldwide, 3 Kima Chemical, 3 Prachin Chemical, 3 Vasa Pharmachem, 3 Ingredion Pharma Solutions, 2 DKSH, 2 Seqens, 2 The Dow Chemical Company, 2 Qualicaps, 2 Nomisma Healthcare, 2 Pharmatrans-Sanaq, 2 Rochem International Inc, 1 Pfanstiehl, 1 Boai NKY Pharmaceuticals Ltd, 1 Aeon Procare, 1 Finar, 1 Nanjing Well Pharmaceutical, 1 Qianhao Chemical (Hebei) Co., Ltd, 1 Ulanqab Kema New Material, 1 Jai Radhe Sales

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60 Fillers, Diluents & Binders, 51 Coating Systems & Additives, 31 Controlled & Modified Release, 27 Direct Compression, 23 Disintegrants & Superdisintegrants, 21 Thickeners and Stabilizers, 20 Granulation, 16 Lubricants & Glidants, 12 Solubilizers, 11 Parenteral, 10 Film Formers & Plasticizers, 10 Co-Processed Excipients, 10 Taste Masking, 9 Topical, 9 Empty Capsules, 6 Chewable & Orodispersible Aids, 5 API Stability Enhancers, 4 Vegetarian Capsules, 3 Emulsifying Agents, 3 Rheology Modifiers, 2 Coloring Agents

GLOBAL SALES INFORMATION

7 US Medicaid Prescriptions, 50 Finished Drug Prices

MARKET PLACE

12 APIs, 7 DOSSIERS // FDF, 1 CONTRACT SERVICES

ANALYTICAL SOLUTION(s)

1 USP Standards, 1 JP Standards, 1 Other Ref. Standards

DIGITAL CONTENT

18 News

18 News

Also known as: Calcium folinate, Calcium citrovorum factor, Folinic acid calcium salt, Folinic acid-sf, calcium salt, (+)-l-folinic acid, calcium salt, 1492-18-8

Molecular Formula

C₂₀H₂₃CaN₇O₇+₂

Molecular Weight

513.5 g/mol

InChI Key

KVUAALJSMIVURS-ZEDZUCNESA-N

The active metabolite of FOLIC ACID. Leucovorin is used principally as an antidote to FOLIC ACID ANTAGONISTS.

1 2D Structure

2D Structure

2 Identification

2.1 Computed Descriptors

2.1.1 IUPAC Name

calcium;(2S)-2-[[4-[(2-amino-5-formyl-4-oxo-3,6,7,8-tetrahydropteridin-6-yl)methylamino]benzoyl]amino]pentanedioic acid

2.1.2 InChI

InChI=1S/C20H23N7O7.Ca/c21-20-25-16-15(18(32)26-20)27(9-28)12(8-23-16)7-22-11-3-1-10(2-4-11)17(31)24-13(19(33)34)5-6-14(29)30;/h1-4,9,12-13,22H,5-8H2,(H,24,31)(H,29,30)(H,33,34)(H4,21,23,25,26,32);/q;+2/t12?,13-;/m0./s1

2.1.3 InChI Key

KVUAALJSMIVURS-ZEDZUCNESA-N

2.1.4 Canonical SMILES

C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)NC(CCC(=O)O)C(=O)O.[Ca+2]

2.1.5 Isomeric SMILES

C1C(N(C2=C(N1)N=C(NC2=O)N)C=O)CNC3=CC=C(C=C3)C(=O)N[C@@H](CCC(=O)O)C(=O)O.[Ca+2]

2.2 Synonyms

2.2.1 MeSH Synonyms

1. 5 Formyltetrahydrofolate

2. 5 Formyltetrahydropteroylglutamate

3. 5-formyltetrahydrofolate

4. 5-formyltetrahydropteroylglutamate

5. Acid, Folinic

6. Calcium Folinate

7. Citrovorum Factor

8. Factor, Citrovorum

9. Folinate, Calcium

10. Folinic Acid

11. Folinic Acid Sf

12. Folinic Acid-sf

13. Leucovorin

14. Leucovorin, (d)-isomer

15. Leucovorin, (dl)-isomer

16. Leucovorin, (r)-isomer

17. Leucovorin, Calcium

18. Leucovorin, Calcium (1:1) Salt

19. Leucovorin, Calcium (1:1) Salt, (dl)-isomer

20. Leucovorin, Calcium (1:1) Salt, Pentahydrate

21. Leucovorin, Monosodium Salt

22. Leukovorin

23. Leukovorum

24. Monosodium Salt Leucovorin

25. N(5)-formyltetrahydrofolate

26. Wellcovorin

2.2.2 Depositor-Supplied Synonyms

1. Calcium Folinate

2. Calcium Citrovorum Factor

3. Folinic Acid Calcium Salt

4. Folinic Acid-sf, Calcium Salt

5. (+)-l-folinic Acid, Calcium Salt

6. 1492-18-8

7. Nsc3590

8. Sr-05000001662

9. Pharmakon1600-01500364

10. Nsc757083

11. Nsc-757083

12. Sr-05000001662-1

13. Sr-05000001662-2

14. Glutamic Acid,6,7,8-tetrahydro-4-hydroxy-6- Pteridinyl)methyl]amino]benzoyl]-, Calcium Salt (1:1), L-

15. L-glutamic Acid,4,5,6,7,8-hexahydro-4-oxo-6- Pteridinyl)methyl]amino]benzoyl]-, Calcium Salt (1:1), (s)-

2.3 Create Date

2019-01-15

3 Chemical and Physical Properties

Molecular Formula	C₂₀H₂₃CaN₇O₇+₂
Molecular Weight	513.5 g/mol
Hydrogen Bond Donor Count	7
Hydrogen Bond Acceptor Count	10
Rotatable Bond Count	9
Exact Mass	513.1284869 g/mol
Monoisotopic Mass	513.1284869 g/mol
Topological Polar Surface Area	216 Å²
Heavy Atom Count	35
Formal Charge	2
Complexity	911
Isotope Atom Count	0
Defined Atom Stereocenter Count	1
Undefined Atom Stereocenter Count	1
Defined Bond Stereocenter Count	0
Undefined Bond Stereocenter Count	0
Covalently Bonded Unit Count	2

4 Pharmacology and Biochemistry

4.1 MeSH Pharmacological Classification

Antidotes

Agents counteracting or neutralizing the action of POISONS. (See all compounds classified as Antidotes.)

Vitamin B Complex

A group of water-soluble vitamins, some of which are COENZYMES. (See all compounds classified as Vitamin B Complex.)

4.2 ATC Code

V - Various

V03 - All other therapeutic products

V03A - All other therapeutic products

V03AF - Detoxifying agents for antineoplastic treatment

V03AF03 - Calcium folinate

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