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    Trilaciclib

    ACTIVE PHARMA INGREDIENTS

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    $ API Ref.Price (USD/KG) : 92,322Xls

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    BIO Partnering at JPM
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    GDUFA

    DMF Review : Complete

    Rev. Date : 2024-10-24

    Pay. Date : 2024-08-07

    DMF Number : 40179

    Submission : 2024-09-05

    Status : Active

    Type : II

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    Looking for 1374743-00-6 / Trilaciclib API manufacturers, exporters & distributors?

    Trilaciclib manufacturers, exporters & distributors 1

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    PharmaCompass offers a list of Trilaciclib API manufacturers, exporters & distributors, which can be sorted by GMP, USDMF, JDMF, KDMF, CEP (COS), WC, Price,and more, enabling you to easily find the right Trilaciclib manufacturer or Trilaciclib supplier for your needs.

    Send us enquiries for free, and we will assist you in establishing a direct connection with your preferred Trilaciclib manufacturer or Trilaciclib supplier.

    PharmaCompass also assists you with knowing the Trilaciclib API Price utilized in the formulation of products. Trilaciclib API Price is not always fixed or binding as the Trilaciclib Price is obtained through a variety of data sources. The Trilaciclib Price can also vary due to multiple factors, including market conditions, regulatory modifications, or negotiated pricing deals.

    API | Excipient name

    Trilaciclib

    Synonyms

    1374743-00-6, G1t28, Cosela, Trilaciclib [usan], U6072do9xg, 2'-((5-(4-methylpiperazin-1-yl)pyridin-2-yl)amino)-7',8'-dihydro-6'h-spiro[cyclohexane-1,9'-pyrazino[1',2':1,5]pyrrolo[2,3-d]pyrimidin]-6'-one

    Cas Number

    1374743-00-6

    Unique Ingredient Identifier (UNII)

    U6072DO9XG

    About Trilaciclib

    Trilaciclib is a small molecule, competitive inhibitor of cyclin dependent kinases 4 and 6 (CDK4/6), with potential antineoplastic and chemoprotective activities. Upon intravenous administration, trilaciclib binds to and inhibits the activity of CDK4/6, thereby blocking the phosphorylation of the retinoblastoma protein (Rb) in early G1. This prevents G1/S phase transition, causes cell cycle arrest in the G1 phase, induces apoptosis, and inhibits the proliferation of CDK4/6-overexpressing tumor cells. In patients with CDK4/6-independent tumor cells, G1T28 may protect against multi-lineage chemotherapy-induced myelosuppression (CIM) by transiently and reversibly inducing G1 cell cycle arrest in hematopoietic stem and progenitor cells (HSPCs) and preventing transition to the S phase. This protects all hematopoietic lineages, including red blood cells, platelets, neutrophils and lymphocytes, from the DNA-damaging effects of certain chemotherapeutics and preserves the function of the bone marrow and the immune system. CDKs are serine/threonine kinases involved in the regulation of the cell cycle and may be overexpressed in certain cancer cell types. HSPCs are dependent upon CDK4/6 for proliferation.

    Trilaciclib Manufacturers

    A Trilaciclib manufacturer is defined as any person or entity involved in the manufacture, preparation, processing, compounding or propagation of Trilaciclib, including repackagers and relabelers. The FDA regulates Trilaciclib manufacturers to ensure that their products comply with relevant laws and regulations and are safe and effective to use. Trilaciclib API Manufacturers are required to adhere to Good Manufacturing Practices (GMP) to ensure that their products are consistently manufactured to meet established quality criteria.

    click here to find a list of Trilaciclib manufacturers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PhamaCompass.

    Trilaciclib Suppliers

    A Trilaciclib supplier is an individual or a company that provides Trilaciclib active pharmaceutical ingredient (API) or Trilaciclib finished formulations upon request. The Trilaciclib suppliers may include Trilaciclib API manufacturers, exporters, distributors and traders.

    click here to find a list of Trilaciclib suppliers with USDMF, JDMF, KDMF, CEP, GMP, COA and API Price related information on PharmaCompass.

    Trilaciclib USDMF

    A Trilaciclib DMF (Drug Master File) is a document detailing the whole manufacturing process of Trilaciclib active pharmaceutical ingredient (API) in detail. Different forms of Trilaciclib DMFs exist exist since differing nations have different regulations, such as Trilaciclib USDMF, ASMF (EDMF), JDMF, CDMF, etc.

    A Trilaciclib DMF submitted to regulatory agencies in the US is known as a USDMF. Trilaciclib USDMF includes data on Trilaciclib's chemical properties, information on the facilities and procedures used, and details about packaging and storage. The Trilaciclib USDMF is kept confidential to protect the manufacturer’s intellectual property.

    click here to find a list of Trilaciclib suppliers with USDMF on PharmaCompass.

    Trilaciclib Manufacturers | Traders | Suppliers

    Trilaciclib Manufacturers, Traders, Suppliers 1
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    We have 1 companies offering Trilaciclib

    Get in contact with the supplier of your choice:

    1. Teva Pharmaceutical Industries
    Inform the supplier about your product requirements, specifying if you need a product with particular monograph like EP (Ph. Eur.), USP, JP, BP, or any other quality. In addition, clarify whether you need hydrochloride (HCl), anhydricum, base, micronisatum or a specific level of purity. To find reputable suppliers, utilize the filters and select those certified by GMP, FDA, or any other certification as per your requirement.
    For your convenience, we have listed synonyms and CAS numbers to help you find the best supplier. The use of synonyms and CAS numbers can be helpful in identifying potential suppliers, but it is crucial to note that they might not always indicate the exact same product. It is important to confirm the product details with the supplier before making a purchase to ensure that it meets your requirements.
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