Spray freeze drying was developed to produce dry powders suitable for applications such as inhalation delivery. In the current study, the spray freeze drying technique was employed to produce inhalable salmon calcitonin microparticles.
Fenretinide, a chemotherapeutic agent for cancer, is water-insoluble and has a very low oral bioavailability. Hence, the objective was to deliver it as an injectable depot and improve the drug solubility and release behavior from poly(lactide-co-glycolide) (PLGA) microspheres by incorporating non-ionic surfactants with fenretinide. Enhancement of drug solubilization was observed with Brij 35 or 98, Tween 20 and Pluronic F127, but not Pluronic F68. Co-incorporation of Brij 98 with fenretinide significantly changed the microsphere morphology improved and fenretinide release profile.
To investigate the modulation of the wettability of excipients by types of surfactants and its impacts on the disintegration of tablets and drug release.
Our objectives were to explore the possibility of avoiding neonatal exposure to potentially harmful excipients of interest (EOI)—parabens, polysorbate 80, propylene glycol, benzoates, saccharin sodium, sorbitol and ethanol—through product substitution in Europe.
Polysorbates (PS) (or surfactants in general) are commonly added to biopharmaceuticals as stabilizers against interface-mediated stresses. They are recognized as critical excipients by the industry as well as regulators. In the last few years, a number of studies have explored PS as raw material, its stability, and its impact on product quality including Borisov et al. (2011), Hewitt et al. (2011), Kishore et al. (2011 and 2011a), Labrenz, and Borisov et al. (2015).
The STEP stands for Safety and Toxicity of Excipients for Paediatrics. The STEP database is a user-designed free resource that compiles the safety and toxicity information of excipients that is manually extracted from selected information sources. Three tier quality control procedures are implemented from information retrieval level to entry of the specific data in the database.