BOSTON, April 11, 2023 /PRNewswire/ -- HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of oral, small molecule allosteric therapies for the treatment of cancer and autoimmune diseases, today announced the recent initiation of dosing of HST-1011 in its Phase 1/2 clinical trial in patients with advanced solid tumors. HST-1011 is an orally bioavailable, potent, selective small molecule allosteric inhibitor of casitas B-lineage lymphoma-B (CBL-B).
HotSpot Therapeutics, Inc., a biotechnology company, announced the clearance by the US Food and Drug Administration (FDA) of the Investigational New Drug (IND) application for HST-1011, the company’s investigational small molecule allosteric inhibitor of casitas B-lineage lymphoma-B (CBL-B). This represents the first IND filing for HotSpot. The company expects to initiate the phase 1/2 study of HST-1011 in the first quarter of 2023, with an initial focus on the evaluation of HST-1011 as monotherapy in patients with advanced solid tumours who are relapsed or refractory to anti-PD(L)1 therapy.
AbbVie has formed a connection with HotSpot Therapeutics, inking a global licensing option deal for the biotech’s preclinical small-molecule allosteric therapy and extending the opportunity for up to $295 million in biobucks.
HYDERABAD, India and BOSTON, May 25, 2022 /PRNewswire/ -- Excelra, a leading global data and digital insights organization, today announced a partnership with HotSpot Therapeutics, Inc., a biotechnology company pioneering the discovery and development of small molecule allosteric therapies for the treatment of cancer and autoimmune diseases. HotSpot Therapeutics plans to deploy data from Excelra's flagship product GOSTAR toward select protein targets to augment its allosteric inhibitor candidate pipeline.
Caris Life Sciences (Caris), the leading molecular science and technology company, and HotSpot Therapeutics, Inc., a biotechnology company, announced a strategic partnership to advance precision medicine approaches for HotSpot’s emerging product portfolio.
HotSpot Therapeutics, the allostery-focused biotech that works on what it calls “natural hotspots” — hence the name — is getting a bit hotter in its valuation from investors. And to that end they’ve raised $100 million.