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Find Clinical Drug Pipeline Developments & Deals by Upstream Bio

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                          Top Deals by Deal Size (USD bn)

                          01

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : The proceeds will advance UPB-101 (verekitug) through the completion of a multi-national, placebo-controlled, randomized Phase 2 in severe asthma, and to initiate subsequent Phase 3 development.

                          Product Name : UPB-101

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          October 10, 2024

                          Lead Product(s) : Verekitug

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : J.P. Morgan

                          Deal Size : $255.0 million

                          Deal Type : Public Offering

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                          02

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : Upstream Bio's investigation product UPB-101 (verekitug), a TLSPR inhibitor, which is being evaluated in Phase II clinical trial studies for patients with severe asthma.

                          Product Name : UPB-101

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          July 03, 2024

                          Lead Product(s) : Verekitug

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : UPB-101 (verekitug) is a fully human immunoglobulin G1 antibody designed to block the thymic stromal lymphopoietin receptor, under phase 2 clinical for Chronic Rhinosinusitis with Nasal Polyps.

                          Product Name : UPB-101

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          March 01, 2024

                          Lead Product(s) : Verekitug

                          Therapeutic Area : Infections and Infectious Diseases

                          Highest Development Status : Phase II

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : UPB-101 is a novel recombinant fully human immunoglobulin G1 (IgG1) monoclonal antibody (mAb) that binds to the human thymic stromal lymphopoietin (TSLP) receptor (TSLPR) to inhibit signaling. UPB-101 is designed to address allergic and inflammatory dise...

                          Product Name : UPB-101

                          Product Type : Antibody

                          Upfront Cash : Inapplicable

                          October 24, 2023

                          Lead Product(s) : Verekitug

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AAPS National Biotech
                          Not Confirmed
                          AAPS National Biotech
                          Not Confirmed

                          Details : The net financing will be used to support the future development of UPB-101, a monoclonal antibody targeting the TSLP receptor, in asthma and chronic rhinosinusitis with nasal polyps (CRSwNP).

                          Product Name : UPB-101

                          Product Type : Antibody

                          Upfront Cash : Undisclosed

                          August 06, 2023

                          Lead Product(s) : Verekitug

                          Therapeutic Area : Pulmonary/Respiratory Diseases

                          Highest Development Status : Phase I

                          Sponsor : Enavate Sciences

                          Deal Size : $200.0 million

                          Deal Type : Series B Financing

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