Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Lead Product(s) : TK-8001
Therapeutic Area : Oncology
Study Phase : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : TK-8001 is a CD8 TCR-T specific for the Melanoma-associated Antigen Gene-A1, or MAGE-A1. TK-8001 TCR-T cells currently being investigated in the IMAG1NE Phase 1/2 clinical trial for MAGE-A1 positive solid tumors.
Product Name : TK-8001
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
January 06, 2023
Lead Product(s) : TK-8001
Therapeutic Area : Oncology
Highest Development Status : Phase I/ Phase II
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : TK-2504
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : TK-2504 is an HLA-A11-restricted CD8 TCR-T specific for KRAS, most frequently mutated oncogenes, and acts as a molecular switch leading to activation of many intracellular signaling pathways involved in regulation of cell growth, cell differentiation and...
Product Name : TK-2504
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
August 04, 2022
Lead Product(s) : TK-2504
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : TK-8001
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : TK-8001 is a CD8 TCR-T specific for the Melanoma-associated Antigen Gene-A1, or MAGE-A1 showed higher affinity than human derived TCRs resulted in superior anti-tumor activity .
Product Name : TK-8001
Product Type : Cell and Gene therapy
Upfront Cash : Inapplicable
November 15, 2021
Lead Product(s) : TK-8001
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : TK-8001
Therapeutic Area : Oncology
Study Phase : IND Enabling
Sponsor : Fidelity Management & Research Company
Deal Size : $110.0 million
Deal Type : Series B Financing
Details : T-knife’s lead program, TK-8001, is a novel TCR-T product candidate targeting MAGE-A1 positive cancers. T-knife Plans to initiate the IMAG1NE Phase 1/2 clinical study of TK-8001, a TCR-T cell therapy for MAGE-A1 positive solid tumors, in 2021.
Product Name : TK-8001
Product Type : Cell and Gene therapy
Upfront Cash : Undisclosed
February 08, 2021
Lead Product(s) : TK-8001
Therapeutic Area : Oncology
Highest Development Status : IND Enabling
Sponsor : Fidelity Management & Research Company
Deal Size : $110.0 million
Deal Type : Series B Financing
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Undisclosed
Sponsor : Catalent Pharma Solutions
Deal Size : Undisclosed
Deal Type : Agreement
Details : Under the terms of the agreement, Catalent will undertake transfer of T-knife´s platform process for T-cell receptor-based cell therapy at its site in Gosselies, Belgium, with the goal of manufacturing clinical batches for European trials in 2021.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
September 21, 2020
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Undisclosed
Sponsor : Catalent Pharma Solutions
Deal Size : Undisclosed
Deal Type : Agreement
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Study Phase : Preclinical
Sponsor : Versant Ventures
Deal Size : $78.0 million
Deal Type : Series A Financing
T-knife Completes €66 Million Series AFinancing to Develop Next-Generation T-Cell Therapies
Details : T-knife’s proprietary humanized mouse platform (HuTCR) T-cell receptors expected to provide superior affinity/specificity properties.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Undisclosed
June 08, 2020
Lead Product(s) : Undisclosed
Therapeutic Area : Oncology
Highest Development Status : Preclinical
Sponsor : Versant Ventures
Deal Size : $78.0 million
Deal Type : Series A Financing