Year
DEALS // DEV.
Country
Therapeutic Area
Study Phase
Deal Type
Product Type
Dosage Form
Lead Product
Target
Details : The funding will be used to evaluate Stealth's mitochondria-targeted molecule, SBT-272, a novel investigational small molecule that targets cardiolipin, a phospholipid within the inner mitochondrial membrane, for Parkinson's disease
Product Name : SBT-272
Product Type : Other Large Molecule
Upfront Cash : Undisclosed
September 08, 2023
Details : SBT-272 significantly improved mitochondrial structural integrity and motility in TDP-43 mutant (A315T)-expressing upper motor neurons. These enhancements in mitochondrial health were associated with improved axon outgrowth, a key indicator of improved n...
Product Name : SBT-272
Product Type : Other Large Molecule
Upfront Cash : Inapplicable
August 06, 2022
Details : Interim results from the Phase 1 study for SBT-272 demonstrated that selected doses are anticipated to result in therapeutic concentrations in the brain based on observed drug levels achieved in preclinical studies.
Product Name : SBT-272
Product Type : Other Large Molecule
Upfront Cash : Inapplicable
January 11, 2022
Lead Product(s) : SBT-272
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : Systemic administration of SBT-272 in rodents resulted in sustained SBT-272 levels across different regions of the brain and protected mitochondria against ischemic stress, confirming that the compound crosses the blood brain barrier and has mitoprotecti...
Product Name : SBT-272
Product Type : Other Large Molecule
Upfront Cash : Inapplicable
July 10, 2021
Lead Product(s) : SBT-272
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : SBT-272
Therapeutic Area : Neurology
Study Phase : Preclinical
Sponsor : Morningside Ventures
Deal Size : $20.0 million
Deal Type : Financing
Details : The Company expects to use proceeds from this capital raise to advance the Company's ongoing development of its lead candidate, elamipretide, its next-generation clinical stage compound, SBT-272.
Product Name : SBT-272
Product Type : Other Large Molecule
Upfront Cash : Undisclosed
April 13, 2020
Lead Product(s) : SBT-272
Therapeutic Area : Neurology
Highest Development Status : Preclinical
Sponsor : Morningside Ventures
Deal Size : $20.0 million
Deal Type : Financing
Stealth BioTherapeutics Initiates First-in-Human Study of SBT-272
Details : Second Generation Mitochondrial Targeted Candidate Enters Clinic with Potential to Treat Neurodegenerative Diseases.
Product Name : SBT-272
Product Type : Other Large Molecule
Upfront Cash : Inapplicable
January 21, 2020