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Health","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"HMNC Brain Health \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"HMNC Brain Health \/ Undisclosed"},{"orgOrder":0,"company":"HMNC Brain Health","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Psychiatry\/Psychology","country":"GERMANY","productType":"Miscellaneous","year":"2023","type":"Inapplicable","leadProduct":"Nelivaptan","moa":"Vasopressin V1b receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"HMNC Brain Health","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"HMNC Brain Health \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"HMNC Brain Health \/ Undisclosed"},{"orgOrder":0,"company":"ATAI Life Sciences","sponsor":"Janus Henderson Investors | Foresite Capital | Deep Track Capital | HBM Partners","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"GERMANY","productType":"Controlled Substance","year":"2025","type":"Public Offering","leadProduct":"Mebufotenin benzoate","moa":"5-HT2A receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"ATAI Life Sciences","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Spray","sponsorNew":"ATAI Life Sciences \/ Janus Henderson Investors | Foresite Capital | Deep Track Capital | HBM Partners","highestDevelopmentStatusID":"8","companyTruncated":"ATAI Life Sciences \/ Janus Henderson Investors | Foresite Capital | Deep Track Capital | HBM Partners"},{"orgOrder":0,"company":"ATAI Life Sciences","sponsor":"Janus Henderson Investors | Foresite Capital | Deep Track Capital | HBM Partners","pharmaFlowCategory":"D","therapeuticArea":"Psychiatry\/Psychology","country":"GERMANY","productType":"Controlled Substance","year":"2025","type":"Public Offering","leadProduct":"Mebufotenin benzoate","moa":"5-HT2A receptor","graph1":"Psychiatry\/Psychology","graph2":"Phase II","graph3":"ATAI Life Sciences","amount2":0.14999999999999999,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Psychiatry","amount2New":0,"dosageForm":"Spray","sponsorNew":"ATAI Life Sciences \/ Janus Henderson Investors | Foresite Capital | Deep Track Capital | HBM Partners","highestDevelopmentStatusID":"8","companyTruncated":"ATAI Life Sciences \/ Janus Henderson Investors | Foresite Capital | Deep Track Capital | HBM Partners"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Lead Product(s) : Mebufotenin benzoate

                          Therapeutic Area : Psychiatry/Psychology

                          Study Phase : Phase II

                          Sponsor : Janus Henderson Investors | Foresite Capital | Deep Track Capital | HBM Partners

                          Deal Size : $149.5 million

                          Deal Type : Public Offering

                          Details : The proceeds from the offering will be used to fund the clinical development of Mebufotenin Benzoate, a controlled substance targeting the 5-HT2A receptor for mental health disorders.

                          Product Name : BPL-003

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          October 20, 2025

                          Lead Product(s) : Mebufotenin benzoate

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Janus Henderson Investors | Foresite Capital | Deep Track Capital | HBM Partners

                          Deal Size : $149.5 million

                          Deal Type : Public Offering

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                          02

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Lead Product(s) : Mebufotenin benzoate

                          Therapeutic Area : Psychiatry/Psychology

                          Study Phase : Phase II

                          Sponsor : Janus Henderson Investors | Foresite Capital | Deep Track Capital | HBM Partners

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

                          Details : The proceeds from the offering will be used to fund the clinical development of Mebufotenin Benzoate, a controlled substance targeting the 5-HT2A receptor for mental health disorders.

                          Product Name : BPL-003

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          October 16, 2025

                          Lead Product(s) : Mebufotenin benzoate

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Janus Henderson Investors | Foresite Capital | Deep Track Capital | HBM Partners

                          Deal Size : Undisclosed

                          Deal Type : Public Offering

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                          03

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : VLS-01, atai’s proprietary oral transmucosal film formulation of N,N-Dimethyltryptamine (DMT) applied to the buccal surface, in people suffering from treatment-resistant depression.

                          Product Name : Undisclosed

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          March 11, 2025

                          Lead Product(s) : Dimethyltryptamine

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : BPL-003 (mebufotenin) is a novel, synthetic, patent-protected benzoate salt formulation of mebufotenin. It is being evaluated for the treatment of treatment-resistant depression.

                          Product Name : Undisclosed

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          March 05, 2025

                          Lead Product(s) : Mebufotenin benzoate

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : The net proceeds from the financing will used to fund the clinical development of VLS-01 (N,N-dimethyltryptamine). It is being evaluated for the treatment of Treatment Resistant Depression.

                          Product Name : Undisclosed

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          February 20, 2025

                          Lead Product(s) : Dimethyltryptamine

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Berenberg

                          Deal Size : $63.2 million

                          Deal Type : Public Offering

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                          06

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : The net proceeds from the financing will used to fund the clinical development of VLS-01 (N,N-dimethyltryptamine). It is being evaluated for the treatment of Treatment Resistant Depression.

                          Product Name : Undisclosed

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          February 12, 2025

                          Lead Product(s) : Dimethyltryptamine

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Berenberg

                          Deal Size : $55.0 million

                          Deal Type : Public Offering

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                          07

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : The net proceeds from the financing will used to fund the clinical development of VLS-01 (N,N-dimethyltryptamine). It is being evaluated for the treatment of Treatment Resistant Depression.

                          Product Name : Undisclosed

                          Product Type : Controlled Substance

                          Upfront Cash : Undisclosed

                          February 12, 2025

                          Lead Product(s) : Dimethyltryptamine

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Berenberg

                          Deal Size : $55.0 million

                          Deal Type : Public Offering

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                          08

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : BPL-003 (mebufotenin) is a novel, synthetic, patent-protected benzoate salt formulation of mebufotenin. It is being evaluated for the treatment of treatment of alcohol use disorder.

                          Product Name : Undisclosed

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          January 28, 2025

                          Lead Product(s) : Mebufotenin benzoate

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          09

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : BH-200 (nelivaptan) is a potent vasopressin V1b receptor antagonist, being investigated in patients with Major Depressive Disorder (MDD).

                          Product Name : Undisclosed

                          Product Type : Miscellaneous

                          Upfront Cash : Inapplicable

                          January 10, 2025

                          Lead Product(s) : Nelivaptan

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Florida Innovation
                          Not Confirmed
                          Florida Innovation
                          Not Confirmed

                          Details : EMP-01 is a Controlled Substance drug candidate, which is currently being evaluated in phase II clinical studies for the treatment of Phobia, Social.

                          Product Name : Undisclosed

                          Product Type : Controlled Substance

                          Upfront Cash : Inapplicable

                          November 18, 2024

                          Lead Product(s) : EMP-01

                          Therapeutic Area : Psychiatry/Psychology

                          Highest Development Status : Phase II

                          Sponsor : EmpathBio

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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