CSBio CSBio

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            Details:

            The joint venture will be settled in the Haikou National High-tech Zone of south China's Hainan Province, and will focus on research in regenerative medicine and cell culture medium, mesenchymal stem cells-based therapies, as well as related commercial operation.

            Lead Product(s): Mesenchymal Stem Cells-based Therapy

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Rohto Pharmaceutical

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Partnership June 24, 2022

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            The agreement grants Radiance an option to license from Biocytogen a first-in-class fully human anti-HER2/TROP2 bispecific antibody-drug conjugate, YH012, for therapeutic product development, manufacturing and commercialization for all human indications worldwide.

            Lead Product(s): YH012

            Therapeutic Area: Oncology Product Name: YH012

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Radiance Biopharma

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement January 08, 2024

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            The collaboration aims to conduct early-stage research for novel bi-specific macrophage engagers, ES019, an anti-PD-L1/SIRPα bispecific antibody, and another program.

            Lead Product(s): ES019

            Therapeutic Area: Oncology Product Name: ES019

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Astellas Pharma

            Deal Size: $1,737.0 million Upfront Cash: Undisclosed

            Deal Type: Collaboration December 27, 2023

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            Under the agreement, Myricx will have exclusive access to a proprietary antibody that was discovered based on WuXi Bio’s integrated technology platforms and develop it into a first-in-class ADC based on its NMTi payload platform.

            Lead Product(s): Undisclosed

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Myricx Bio

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Licensing Agreement November 21, 2023

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            Under the terms of the agreement, AstraZeneca will receive an exclusive global license to research, develop and commercialize UA022, a potent, selective oral small molecule drug targeting the KRASG12D mutation.

            Lead Product(s): UA022

            Therapeutic Area: Oncology Product Name: UA022

            Highest Development Status: Preclinical Product Type: Small molecule

            Partner/Sponsor/Collaborator: AstraZeneca

            Deal Size: $419.0 million Upfront Cash: $24.0 million

            Deal Type: Licensing Agreement November 20, 2023

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            Under the terms of the agreement, MediLink will grant BioNTech exclusive global rights for the development, manufacturing, and commercialization of one of MediLink's ADC assets, against Human Epidermal Growth Factor Receptor 3 (HER3).

            Lead Product(s): Undisclosed

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: BioNTech

            Deal Size: $1,070.0 million Upfront Cash: $70.0 million

            Deal Type: Licensing Agreement October 12, 2023

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            The agreement aims to advance the innovative bispecific antibody drug project by leveraging Sanyou's world-leading core technology platform for integrated R&D and preclinical development and Sinorda's rich experience in preclinical and clinical oncology immunotherapy.

            Lead Product(s): Bispecific Antibody

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: Sinorda Biomedicine

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement August 22, 2023

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            The collaboration aims to investigate CARsgen's investigational CT041 (satricabtagene autoleucel), a Claudin18.2 CAR T-cell product candidate, in combination with Moderna’s investigational Claudin18.2 mRNA cancer vaccine.

            Lead Product(s): Satricabtagene Autoleucel,Claudin18.2 mRNA Vaccine

            Therapeutic Area: Oncology Product Name: CT041

            Highest Development Status: Preclinical Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Moderna Therapeutics

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration August 21, 2023

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            Under the terms of the agreement, Biotheus will grant BioNTech worldwide, exclusive options to a preclinical-stage bispecific antibody and a clinical-stage monoclonal antibody for cancer therapy.

            Lead Product(s): Bispecific Antibody

            Therapeutic Area: Oncology Product Name: Undisclosed

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: BioNTech

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Collaboration July 19, 2023

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            Under the agreement, BeiGene will acquire an exclusive option for a global clinical and commercial license to DB-1312, an investigational, preclinical antibody-drug conjugate therapy for solid tumors and DualityBio will continue preclinical research and support IND filing.

            Lead Product(s): DB-1312

            Therapeutic Area: Oncology Product Name: DB-1312

            Highest Development Status: Preclinical Product Type: Large molecule

            Partner/Sponsor/Collaborator: BeiGene

            Deal Size: $1,300.0 million Upfront Cash: Undisclosed

            Deal Type: Agreement July 10, 2023

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