[{"orgOrder":0,"company":"NovalGen","sponsor":"Mabion SA","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Antibody, Unconjugated","year":"2025","type":"Partnership","leadProduct":"NVG-222","moa":"ROR1\/CD3","graph1":"Oncology","graph2":"IND Enabling","graph3":"NovalGen","amount2":0,"highestDevelopmentShortName":"IND","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"NovalGen \/ Mabion SA","highestDevelopmentStatusID":"5","companyTruncated":"NovalGen \/ Mabion SA"},{"orgOrder":0,"company":"NovalGen","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Antibody, Unconjugated","year":"2021","type":"Inapplicable","leadProduct":"NVG-111","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"NovalGen","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"NovalGen \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"NovalGen \/ Undisclosed"},{"orgOrder":0,"company":"NovalGen","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Antibody, Unconjugated","year":"2022","type":"Inapplicable","leadProduct":"NVG-111","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"NovalGen","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"NovalGen \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"NovalGen \/ Undisclosed"},{"orgOrder":0,"company":"NovalGen","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Antibody, Unconjugated","year":"2022","type":"Inapplicable","leadProduct":"NVG-111","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase II","graph3":"NovalGen","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"NovalGen \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"NovalGen \/ Undisclosed"},{"orgOrder":0,"company":"NovalGen","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"UNITED KINGDOM","productType":"Antibody, Unconjugated","year":"2021","type":"Inapplicable","leadProduct":"NVG-111","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I\/ Phase II","graph3":"NovalGen","amount2":0,"highestDevelopmentShortName":"Ph I\/II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"NovalGen \/ Undisclosed","highestDevelopmentStatusID":"7","companyTruncated":"NovalGen \/ Undisclosed"},{"orgOrder":0,"company":"NovalGen","sponsor":"Halix BV","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"NETHERLANDS","productType":"Antibody, Unconjugated","year":"2021","type":"Partnership","leadProduct":"NVG-111","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"NovalGen","amount2":0,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Infusion","sponsorNew":"NovalGen \/ NovalGen","highestDevelopmentStatusID":"6","companyTruncated":"NovalGen \/ NovalGen"}]

Find Clinical Drug Pipeline Developments & Deals by NovalGen

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                          Therapeutic Area by Lead Product

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                          Top Deals by Deal Size (USD bn)

                          01

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : The partnership aims to bring the proprietary T-cell engager, NVG-222 targeting ROR1 and CD3, to market for phase one of in-human clinical trials.

                          Product Name : NVG-222

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          June 30, 2025

                          Lead Product(s) : NVG-222

                          Therapeutic Area : Oncology

                          Highest Development Status : IND Enabling

                          Sponsor : Mabion SA

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          02

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : NVG-111 is generally well tolerated with a predictable and manageable safety profile. Promising evidence of efficacy was observed which appears to be durable in two subjects with MRD4 negative CR.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          November 03, 2022

                          Lead Product(s) : NVG-111

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : NVG-111 was well tolerated with the most common adverse event being transient, Grade 1 lethargy, headaches, nausea, vomiting and thrombocytopenia. Dose escalation is ongoing, including exploration of step-up dosing.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          May 26, 2022

                          Lead Product(s) : NVG-111

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : NVG-111 is a first in class bispecific antibody T cell engager targeting receptor tyrosine kinase-like orphan receptor 1 (ROR1).

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          May 20, 2021

                          Lead Product(s) : NVG-111

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : HALIX will provide manufacturing and clinical supply of NovalGen's therapies as part of this partnership. HALIX has supported NovalGen with the successful completion of GMP manufacture of NVG-111 from drug substance up to drug product and final release.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Undisclosed

                          February 22, 2021

                          Lead Product(s) : NVG-111

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Recipient : Halix BV

                          Deal Size : Undisclosed

                          Deal Type : Partnership

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                          06

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : NVG-111 is a Antibody drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Leukemia, Lymphocytic, Chronic, B-Cell.

                          Product Name : Undisclosed

                          Product Type : Antibody, Unconjugated

                          Upfront Cash : Inapplicable

                          February 21, 2021

                          Lead Product(s) : NVG-111

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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