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(lotilaner) for the Prevention of Lyme Disease","therapeuticArea":"Infections and Infectious Diseases","highestDevelopmentStatus":"Phase II","country":"U.S.A","productType":"Small molecule","productStatus":"New Molecular Entity","date":"February 2024","url1":"","url2":"","graph1":"Small molecule","graph2":"Tarsus Pharmaceuticals"}]

Find Drugs for Infections and Infectious Diseases in Phase II Clinical Development in UNITED STATES

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            The Phase 2 interim results of VAT00002 showed 95% to 100% seroconversion following a second injection in all age groups (18 to 95 years old) and across all doses, with acceptable tolerability and with no safety concerns.

            Lead Product(s): SARS-CoV-2 Recombinant Protein Vaccine

            Therapeutic Area: Infections and Infectious Diseases Product Name: VAT00002

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: GSK

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable May 17, 2021

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            TMF Summit 2024

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            The new Phase 2 trial is a randomized, double-blind, multi-center dose finding study conducted in adults aged 18 years of age and older to evaluate the safety, reactogenicity, and immunogenicity of two Adjuvanted recombinant protein-based COVID-19 vaccine given 21 days apart.

            Lead Product(s): Adjuvanted recombinant protein-based COVID-19 vaccine

            Therapeutic Area: Infections and Infectious Diseases Product Name: Undisclosed

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: GSK

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 22, 2021

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            Under the agreement, Fareva will fill & finish manufacturing of CureVac´s COVID-19 vaccine candidate, CVnCoV, a COVID-19 vaccine candidate developed by CureVac, in France.

            Lead Product(s): CVnCoV

            Therapeutic Area: Infections and Infectious Diseases Product Name: CVnCoV

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: CureVac

            Deal Size: Undisclosed Upfront Cash: Undisclosed

            Deal Type: Agreement December 08, 2020

            Details:

            Dr Reddy's recently received permission from DCGI to conduct phase II and III trials of the Russian vaccine. If it receives an approval to continue, it will recruit 1,400 subjects for phase III.

            Lead Product(s): Gam-COVID-Vac

            Therapeutic Area: Infections and Infectious Diseases Product Name: Sputnik V

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable October 28, 2020

            Details:

            TP-05 (lotilaner) is an oral, well-characterized anti-parasitic agent that selectively inhibits parasite-specific GABA-Cl channels. It is being evaluated for the prevention of Lyme Disease.

            Lead Product(s): Lotilaner

            Therapeutic Area: Infections and Infectious Diseases Product Name: TP-05

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 22, 2024

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            Allocetra-OTS is a cell-based therapy consisting of non-HLA-matched allogeneic peripheral blood mononuclear cells. It is under phase 2 clinical trials for sepsis associated with pneumonia, biliary, urinary tract, or peritoneal infections.

            Lead Product(s): Allocetra-OTS

            Therapeutic Area: Infections and Infectious Diseases Product Name: Allocetra

            Highest Development Status: Phase II Product Type: Cell and Gene therapy

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable February 21, 2024

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            ACX-362E (ibezapolstat) is a novel, orally administered antibiotic being developed as a GPSS antibacterial. It is the first of a new class of DNA polymerase IIIC inhibitor which is under phase 2 clinical development for the treatment of Clostridioides difficile infection.

            Lead Product(s): Ibezapolstat

            Therapeutic Area: Infections and Infectious Diseases Product Name: ACX-362E

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 17, 2024

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            NRX-101 (a fixed dose combination of D-cycloserine (DCS) and lurasidone HCl (lurasidone)) is an active antibiotic ingredient, NMDA receptor modulator which is under phase 2 clinical development for the treatment of complicated urinary tract infection and pyelonephritis.

            Lead Product(s): Cycloserine,Lurasidone Hydrochloride

            Therapeutic Area: Infections and Infectious Diseases Product Name: NRX-101

            Highest Development Status: Phase II Product Type: Small molecule

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 16, 2024

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            Ixchiq (Chikungunya Vaccine, Live) Intramuscular Injection is a vaccine indicated for the prevention of disease caused by chikungunya virus (CHIKV). It is being evaluated in phase 2 clinical trials evaluating the safety and Immunogenicity in children,

            Lead Product(s): Chikungunya Vaccine

            Therapeutic Area: Infections and Infectious Diseases Product Name: Ixchiq

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: Not Applicable

            Deal Size: Not Applicable Upfront Cash: Not Applicable

            Deal Type: Not Applicable January 10, 2024

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            Under the agreement, Vaxcyte obtains exclusive rights to independently develop and manufacture cell-free extract, a key component of the company’s 24-valent pneumococcal conjugate vaccine (PCV) franchise which includes VAX-24 and VAX-31.

            Lead Product(s): 24-valent Pneumococcal Conjugate Vaccine

            Therapeutic Area: Infections and Infectious Diseases Product Name: VAX-24

            Highest Development Status: Phase II Product Type: Vaccine

            Partner/Sponsor/Collaborator: Vaxcyte

            Deal Size: $135.0 million Upfront Cash: $135.0 million

            Deal Type: Agreement November 27, 2023

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