Lead Product(s) : MRT5400
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Translate Bio
Deal Size : Inapplicable
Deal Type : Inapplicable
Sanofi and Translate Bio Initiate Phase 1 Clinical Trial of mRNA Influenza Vaccine
Details : Sanofi and Translate Bio have developed and will evaluate two formulations of the vaccine (MRT5400 and MRT5401) in the Phase 1 influenza mRNA vaccine clinical trial. The two formulations differ in the lipid nanoparticle (LNP) that contains the mRNA.
Product Name : MRT5400
Product Type : Vaccine
Upfront Cash : Inapplicable
June 22, 2021
Lead Product(s) : MRT5400
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Translate Bio
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : MRT5400
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Translate Bio
Deal Size : Inapplicable
Deal Type : Inapplicable
Sanofi and Translate Bio Initiate Phase 1 Clinical Trial of mRNA Influenza Vaccine
Details : Sanofi and Translate Bio have developed and will evaluate two formulations of the vaccine (MRT5400 and MRT5401) in the Phase 1 influenza mRNA vaccine clinical trial. The two formulations differ in the lipid nanoparticle (LNP) that contains the mRNA.
Product Name : MRT5400
Product Type : Vaccine
Upfront Cash : Inapplicable
June 22, 2021
Lead Product(s) : MRT5400
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Translate Bio
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : DNL758
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Denali Therapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable
Sanofi Begins Dosing of DNL758 in Phase Ib Covid-19 Trial
Details : Dosing of DNL758 has commenced in a randomized, double-blind, placebo-controlled Phase 1b trial to evaluate safety and effect on the immune system in severe COVID-19.
Product Name : SAR443122
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
July 30, 2020
Lead Product(s) : DNL758
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Denali Therapeutics
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : OVX033
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Osivax Completes Enrollment for Phase 1 Sarbecovirus Vaccine Candidate OVX033
Details : OVX033 is a first-in-class coronavirus vaccine, targetting nucleocapsid (N), a highly conserved internal antigen, which is much less likely to mutate, providing a broader & universal immune response.
Product Name : OVX033
Product Type : Vaccine
Upfront Cash : Inapplicable
June 25, 2024
Lead Product(s) : OVX033
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CER-001
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
ABIONYX Completes Successful Pre-IND Meeting with FDA for CER-001 Trial for Sepsis
Details : CER-001 is a novel recombinant human apolipoprotein A-I (apoA-I) stimulant, which is currently being evaluated for the treatment of patients with Sepsis.
Product Name : CER-001
Product Type : Protein
Upfront Cash : Inapplicable
June 13, 2024
Lead Product(s) : CER-001
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
PHAXIAM Enrolls First Patient in Phase 1 Study for Staphylococcus Aureus Endocarditis
Details : An intravenous macrophage based therapy is being investigated in phase 1 trial for the treatment of endocarditis infection caused by Staphylococcus aureus.
Product Name : Undisclosed
Product Type : Undisclosed
Upfront Cash : Inapplicable
April 15, 2024
Lead Product(s) : Undisclosed
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : VLA1601
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Valneva Initiates Phase 1 Trial of Second-Generation Zika Vaccine Candidate
Details : VLA1601 is a highly purified inactivated zika virus vaccine candidate adsorbed on alum, which is being evaluated for the treatment of zika virus infection.
Product Name : VLA1601
Product Type : Vaccine
Upfront Cash : Inapplicable
March 26, 2024
Lead Product(s) : VLA1601
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : OVX033
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Osivax Vaccinates First Participant in Sarbecovirus Vaccine Trial
Details : OVX033 is a first-in-class coronavirus vaccine candidate targeting the nucleocapsid, providing a broader immune response due to lower mutation likelihood compared to surface antigens.
Product Name : OVX033
Product Type : Vaccine
Upfront Cash : Inapplicable
February 15, 2024
Lead Product(s) : OVX033
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : ANT3310,Meropenem
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : MEM-ANT3310 combines the well-known carbapenem meropenem (MEM) with ANT3310, a breakthrough serine-beta-lactamase (SBL) inhibitor.
Product Name : ANT3310
Product Type : Other Small Molecule
Upfront Cash : Inapplicable
May 25, 2023
Lead Product(s) : ANT3310,Meropenem
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Lead Product(s) : CD40.HIVRI.Env,Poly-ICLC
Therapeutic Area : Infections and Infectious Diseases
Study Phase : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable
Details : The CD40.HIVRI.Env vaccine candidate is developed by the VRI that targets an immune response binding HIV envelope protein to monoclonal antibodies specifically targeting CD40 receptors on the surface of dendritic cells.
Product Name : CD40.HIVRI.Env
Product Type : Vaccine
Upfront Cash : Inapplicable
February 22, 2023
Lead Product(s) : CD40.HIVRI.Env,Poly-ICLC
Therapeutic Area : Infections and Infectious Diseases
Highest Development Status : Phase I
Sponsor : Inapplicable
Deal Size : Inapplicable
Deal Type : Inapplicable