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The proceeds will be used for the development of second-generation highly selective and third-generation tissue-specific JAK inhibitors, including LNK01001, while also exploring the potential of innovative target-based drug development.
LNK01001 is a JAK1 selective inhibitor which is being investigated in patients with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerant to conventional synthetic disease-modifying anti-rheumatic drugs.
LNK01001 is a JAK1 selective inhibitor which is being investigated in patients with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerant to conventional synthetic disease-modifying anti-rheumatic drugs.
The proceeds from the round of financing will be used to accelerate the clinical development of Lynk Pharmaceuticals' core products including, LNK01001, a JAK1 selective inhibitor for the treatment of autoimmune diseases.
LNK01001 is a JAK1 selective inhibitor which is being investigated in patients with moderately to severely active rheumatoid arthritis who have had an inadequate response or intolerant to conventional synthetic disease-modifying anti-rheumatic drugs.
IBI311 is a recombinant anti-IGF-1R antibody. It blocks IGF-1R signaling pathway activation to reduce the expression of downstream inflammatory factors in thyroid ophthalmopathy and improving proptosis, diplopia, ocular congestion and edema.
RC18 (telitacicept) targets two cell-signaling molecules critical for B-lymphocyte development: BLyS and a proliferation inducing ligand, which allows it to effectively reduce B-cell mediated autoimmune responses that are implicated in several autoimmune diseases.
KP104 is a first-in-class bifunctional biologic designed to simultaneously and selectively block both the alternative and terminal complement pathways, providing a powerful and synergistic method of targeting validated drivers of complement-mediated disease.
ICP-022 (orelabrutinib) is a highly selective BTK inhibitor developed by InnoCare for the treatment of cancers and autoimmune diseases. The plasma exposure of orelabrutinib (AUC and Cmax) was proportionally increased with doses.
Under the terms of the agreement, Lynk Pharmaceuticals is responsible for the development of the product. Simcere will obtain the exclusive rights to market LNK01001 for the indications of rheumatoid arthritis and ankylosing spondylitis in China.