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    Find Immunology Drugs in Phase I Clinical Development in UNITED STATES

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              Alpine Immune Sciences

              • Development Update

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              UNITED STATES United States

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              WRIB

              Participation Not Confirmed

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              Alpine Immune Sciences’ ALPN-101 Receives FDA Orphan Drug Designations

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              Lead Product(s): ALPN-101

              Therapeutic Area: Immunology

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 18, 2020

              Details:

              FDA has made two orphan drug designations for ALPN-101, Alpine’s first-in-class selective dual T cell costimulation inhibitor, for the prevention and for the treatment of acute GVHD.

              Evelo Biosciences

              • Development Update

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              UNITED STATES United States

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              WRIB

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              Evelo Biosciences Announces Biomarker Data Showing EDP1815

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              Lead Product(s): EDP1815

              Therapeutic Area: Immunology

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 02, 2020

              Details:

              Interim data from individuals in the ongoing Phase 1b clinical trial showed marked activity on multiple individual systemic markers of inflammation.

              ARS Pharmaceuticals

              • Development Update

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              UNITED STATES United States

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              WRIB

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              Epinephrine Nasal Spray Demonstrates Bioequivalent Exposure

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              Lead Product(s): Epinephrine

              Therapeutic Area: Immunology

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable March 02, 2020

              Details:

              Epinephrine nasal spray demonstrated a bioequivalent exposure to a 0.3 mg intramuscular dose that was given once by a needle and syringe.

              Harbour BioMed

              • Development Update

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              UNITED STATES United States

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              WRIB

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              Harbour BioMed Announces Completion of Phase 1 Study in China of HBM9161, an Anti-FcRn Antibody

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              Lead Product(s): HBM9161

              Therapeutic Area: Immunology

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable February 21, 2020

              Details:

              The results demonstrated an excellent safety profile and potent IgG reduction capability. The full study will be presented at an upcoming international conference.

              INmune Bio

              • Deals

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              UNITED STATES United States

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              WRIB

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              INmune Bio, Inc. Awarded $500,000 Grant

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              Lead Product(s): XPro1595

              Therapeutic Area: Immunology

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: ALS Association

              Deal Size: $0.5 million Upfront Cash: Undisclosed

              Deal Type: Funding February 10, 2020

              Details:

              The grant will fund proof-of-concept studies for XPro1595, a novel therapy targeting innate immune dysfunction and chronic inflammation as a cause of Amyotrophic lateral sclerosis (ALS).

              Xencor

              • Deals

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              UNITED STATES United States

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              WRIB

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              Aimmune Licenses Worldwide Rights to Xencor’s XmAb®7195

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              Lead Product(s): XmAb7195

              Therapeutic Area: Immunology

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Aimmune Therapeutics

              Deal Size: $395.0 million Upfront Cash: $10.0 million

              Deal Type: Licensing Agreement February 05, 2020

              Details:

              Aimmune Therapeutics has obtained an exclusive worldwide license to develop and commercialize the investigational humanized monoclonal antibody XmAb®7195 from Xencor, Inc.

              Jasper Therapeutics

              • Deals

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              UNITED STATES United States

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              WRIB

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              Jasper Therapeutics Announces Expansion of Series A Financing, Bringing Total Corporate Fundraising to More than $50 Million

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              Lead Product(s): JSP191

              Therapeutic Area: Immunology

              Highest Development Status: Phase I Product Type: Large molecule

              Partner/Sponsor/Collaborator: Abingworth

              Deal Size: $50.0 million Upfront Cash: Undisclosed

              Deal Type: Series A Financing January 09, 2020

              Details:

              Funds will be used to advance JSP191, the first clinical-stage antibody designed for use as a single and combination conditioning agent in patients undergoing curative allogeneic hematopoietic cell transplan

              Aclaris Therapeutics

              • Development Update

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              UNITED STATES United States

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              WRIB

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              Aclaris Therapeutics Announces Positive Results From Phase 1 Single and Multiple Ascending Dose Trial of ATI-450, an Investigational Oral MK...

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              Lead Product(s): ATI-450,Methotrexate

              Therapeutic Area: Immunology

              Highest Development Status: Phase I Product Type: Small molecule

              Partner/Sponsor/Collaborator: Not Applicable

              Deal Size: Not Applicable Upfront Cash: Not Applicable

              Deal Type: Not Applicable January 09, 2020

              Details:

              ATI-450 resulted in inhibition of TNF?, IL1?, IL8, and IL6, was generally well-tolerated at all doses tested in the trial; had no significant food effect or drug-drug interaction with methotrexate.

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