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    [{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Merck & Co","pharmaFlowCategory":"D","therapeuticArea":"Oncology","country":"FRANCE","productType":"Miscellaneous","year":"2022","type":"Collaboration","leadProduct":"5-Methyltetrazole","moa":"A2AR\/BR","graph1":"Oncology","graph2":"Phase I","graph3":"Domain Therapeutics","amount2":0.26000000000000001,"highestDevelopmentShortName":"Ph I","therapeuticAreaShortName":"Oncology","amount2New":0.26000000000000001,"dosageForm":"Undisclosed","sponsorNew":"Domain Therapeutics \/ Merck & Co","highestDevelopmentStatusID":"6","companyTruncated":"Domain Therapeutics \/ Merck & Co"},{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"FRANCE","productType":"Miscellaneous","year":"2022","type":"Inapplicable","leadProduct":"DT-9081","moa":"EP4 receptor","graph1":"Oncology","graph2":"Phase I","graph3":"Domain 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Therapeutics","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"FRANCE","productType":"Miscellaneous","year":"2024","type":"Inapplicable","leadProduct":"DT-9045","moa":"Undisclosed","graph1":"Oncology","graph2":"Preclinical","graph3":"Domain Therapeutics","amount2":0,"highestDevelopmentShortName":"Preclinical","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Domain Therapeutics \/ Undisclosed","highestDevelopmentStatusID":"4","companyTruncated":"Domain Therapeutics \/ Undisclosed"},{"orgOrder":0,"company":"Domain Therapeutics","sponsor":"Domain Therapeutics","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"FRANCE","productType":"Miscellaneous","year":"2025","type":"Inapplicable","leadProduct":"DT-7012","moa":"Undisclosed","graph1":"Oncology","graph2":"Phase I","graph3":"Domain Therapeutics","amount2":0,"highestDevelopmentShortName":"Ph 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    Find Clinical Drug Pipeline Developments & Deals by Domain Therapeutics

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                            01

                            Domain Therapeutics

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                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Recipient : Assistance Publique – Hôpitaux de Paris

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            A Phase 1, Multicenter, Open-label, Prospective, First-in-human Dose-escalation Clinical Trial of Domain Thera...

                            Details : DT-7012 is a large molecule drug candidate, which is currently being evaluated in Phase I clinical studies for the treatment of Lymphoma, T-Cell, Cutaneous.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 09, 2025

                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Recipient : Assistance Publique – Hôpitaux de Paris

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            02

                            Domain Therapeutics

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                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Study Phase : Phase I/ Phase II

                            Sponsor : Domain Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Study of DT-7012 as a Single Agent and in Combination With an Immune Checkpoint Inhibitor in Participants With...

                            Details : DT-7012 is a Other Large Molecule drug candidate, which is currently being evaluated in phase I/ phase II clinical studies for the treatment of Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            February 11, 2025

                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I/ Phase II

                            Sponsor : Domain Therapeutics

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            03

                            Domain Therapeutics

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                            Lead Product(s) : DT-9045

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Domain Therapeutics to Present DT-9045 Data, a Novel Modulator for Immuno-oncology

                            Details : DT-9045 is a novel protease-activated receptor 2 (PAR2) negative allosteric modulator, small molecule drug candidate. It is being evaluated for the treatment of cancer.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            March 26, 2024

                            Lead Product(s) : DT-9045

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            04

                            Domain Therapeutics

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                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Recipient : Chime Biologics

                            Deal Size : Undisclosed

                            Deal Type : Agreement

                            DEALS_DEV arrow-down

                            Domain Therapeutics and Chime Announce Manufacturing Deal for Anti-Ccr8 Cancer Antibody

                            Details : Through the agreement, the company will focus on the clinical development of DT-7012, a CCR8 antibody candidate. Currently, it is being evaluated in preclinical trial studies for Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            March 12, 2024

                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Recipient : Chime Biologics

                            Deal Size : Undisclosed

                            Deal Type : Agreement

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                            05

                            Domain Therapeutics

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                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Agence Nationale de la Recherche

                            Deal Size : Undisclosed

                            Deal Type : Funding

                            DEALS_DEV arrow-down

                            Domain Therapeutics Awarded Grant To Progress CCR8 Antibody Candidate

                            Details : A grant supports clinical progress of DT-7012, an anti-CCR8 monoclonal antibody, in preclinical studies for cutaneous T-cell lymphoma and other neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            January 25, 2024

                            Lead Product(s) : DT-7012

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Agence Nationale de la Recherche

                            Deal Size : Undisclosed

                            Deal Type : Funding

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                            06

                            Domain Therapeutics

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                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Domain Therapeutics Announces First Patient Dosed With DT-9081 In Phase I Clinical Study In Patients With Adva...

                            Details : DT-9081 is an oral small molecule product which, by blocking the EP4 receptor present on immune cells, is able to reverse the prostaglandin E2 (PGE2)-mediated immunosuppression triggered by some tumors to bypass the immune system.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            January 05, 2023

                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            07

                            Domain Therapeutics

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                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Domain Therapeutics To Progress Into Clinical Trials With Its EP4R Antagonist DT-9081 In Solid Tumors

                            Details : DT-9081 is an oral small molecule drug candidate, which is able to reverse the prostaglandin E2 (PGE2)-mediated immunosuppression triggered by some tumors to bypass the immune system, by blocking the EP4 receptor present on immune cells.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 19, 2022

                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            08

                            Domain Therapeutics

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                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            DT-9081 Study in Participants with Advanced, Recurrent or Metastatic Solid Tumours

                            Details : DT-9081 is a Other Small Molecule drug candidate, which is currently being evaluated in phase I clinical studies for the treatment of Neoplasms.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 17, 2022

                            Lead Product(s) : DT-9081

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            09

                            Domain Therapeutics

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                            Lead Product(s) : DT-9081,Undisclosed

                            Therapeutic Area : Oncology

                            Study Phase : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

                            DEALS_DEV arrow-down

                            Domain Therapeutics To Present New Data On Its EP4R and CCR8 Antagonists at 2022 SITC Annual Meeting

                            Details : DT-9081 is a selective EP4 receptor antagonist which synergizes with immune checkpoint inhibitors to induce complete responses in syngeneic murine cancer models.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Inapplicable

                            October 06, 2022

                            Lead Product(s) : DT-9081,Undisclosed

                            Therapeutic Area : Oncology

                            Highest Development Status : Preclinical

                            Sponsor : Undisclosed

                            Deal Size : Inapplicable

                            Deal Type : Inapplicable

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                            10

                            Domain Therapeutics

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                            Lead Product(s) : 5-Methyltetrazole

                            Therapeutic Area : Oncology

                            Study Phase : Phase I

                            Sponsor : Merck & Co

                            Deal Size : $261.0 million

                            Deal Type : Collaboration

                            DEALS_DEV arrow-down

                            Domain Therapeutics Receives a Single Digit Multimillion Development Milestone Payment from Merck For M1069 Cl...

                            Details : A2a/A2b antagonist candidate, M1069, a first-in-human study to investigate the safety, tolerability, PK/PD and clinical activity in patients with metastatic or locally advanced unresectable solid tumors.

                            Product Name : Undisclosed

                            Product Type : Miscellaneous

                            Upfront Cash : Undisclosed

                            June 28, 2022

                            Lead Product(s) : 5-Methyltetrazole

                            Therapeutic Area : Oncology

                            Highest Development Status : Phase I

                            Sponsor : Merck & Co

                            Deal Size : $261.0 million

                            Deal Type : Collaboration

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