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International","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"Fatty Acid","moa":"Undisclosed","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Ablon Skin Institute Research Center","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Gel","sponsorNew":"Ablon Skin Institute Research Center \/ U.S. Nutraceuticals, Inc. dba Valensa International","highestDevelopmentStatusID":"1","companyTruncated":"Ablon Skin Institute Research Center \/ U.S. Nutraceuticals, Inc. dba Valensa International"},{"orgOrder":0,"company":"Topix Skin Health","sponsor":"University of Minnesota","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Undisclosed","year":"2024","type":"Partnership","leadProduct":"ProteXidine","moa":"Undisclosed","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Topix Skin Health","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Topix Skin Health \/ University of Minnesota","highestDevelopmentStatusID":"1","companyTruncated":"Topix Skin Health \/ University of Minnesota"},{"orgOrder":0,"company":"Clearstem Skincare","sponsor":"Citruslabs","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2023","type":"Inapplicable","leadProduct":"Vitamin A","moa":"NR1B","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Clearstem Skincare","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Clearstem Skincare \/ Citruslabs","highestDevelopmentStatusID":"1","companyTruncated":"Clearstem Skincare \/ Citruslabs"},{"orgOrder":0,"company":"Scale Media Inc","sponsor":"Citruslabs","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2024","type":"Inapplicable","leadProduct":"Vitamin","moa":"Undisclosed","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Scale Media Inc","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Scale Media Inc \/ Citruslabs","highestDevelopmentStatusID":"1","companyTruncated":"Scale Media Inc \/ Citruslabs"},{"orgOrder":0,"company":"Standard Process Inc.","sponsor":"Inapplicable","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2025","type":"Inapplicable","leadProduct":"Vitamin C Supplement","moa":"Undisclosed","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Standard Process Inc.","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Standard Process Inc. \/ Inapplicable","highestDevelopmentStatusID":"1","companyTruncated":"Standard Process Inc. \/ Inapplicable"},{"orgOrder":0,"company":"Pressure BioSciences","sponsor":"QVC Skincare","pharmaFlowCategory":"D","therapeuticArea":"Dermatology","country":"U.S.A","productType":"Vitamins\/Minerals\/Inorganic Salts","year":"2022","type":"Partnership","leadProduct":"Vitamin A","moa":"NR1B","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Pressure BioSciences","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Pressure BioSciences \/ QVC Skincare","highestDevelopmentStatusID":"1","companyTruncated":"Pressure BioSciences \/ QVC Skincare"},{"orgOrder":0,"company":"Zest Healthtech PLT","sponsor":"UCSI University","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Plant Extract\/Herbal","year":"2025","type":"Inapplicable","leadProduct":"Melicope Ptelefolia Extract","moa":"Undisclosed","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Zest Healthtech PLT","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Zest Healthtech PLT \/ UCSI University","highestDevelopmentStatusID":"1","companyTruncated":"Zest Healthtech PLT \/ UCSI University"},{"orgOrder":0,"company":"Olistic Research Labs S.L.","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Olistic Research Labs S.L.","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Olistic Research Labs S.L. \/ Undisclosed","highestDevelopmentStatusID":"1","companyTruncated":"Olistic Research Labs S.L. \/ Undisclosed"},{"orgOrder":0,"company":"Olistic Research Labs S.L.","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Olistic Research Labs S.L.","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Olistic Research Labs S.L. \/ Undisclosed","highestDevelopmentStatusID":"1","companyTruncated":"Olistic Research Labs S.L. \/ Undisclosed"},{"orgOrder":0,"company":"Center for Clinical and Cosmetic Research","sponsor":"Restore Biologics Holdings, LLC | Xtress\u00e9 (TM)","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Dietary Supplement","year":"2025","type":"Inapplicable","leadProduct":"Xtress\u00e9 Supplement","moa":"Undisclosed","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Center for Clinical and Cosmetic Research","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Center for Clinical and Cosmetic Research \/ Restore Biologics Holdings, LLC | Xtress\u00e9 (TM)","highestDevelopmentStatusID":"1","companyTruncated":"Center for Clinical and Cosmetic Research \/ Restore Biologics Holdings, LLC | Xtress\u00e9 (TM)"},{"orgOrder":0,"company":"Two Lines LLC","sponsor":"Citruslabs","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"","productType":"Undisclosed","year":"2025","type":"Inapplicable","leadProduct":"Undisclosed","moa":"Undisclosed","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Two Lines LLC","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Tablet","sponsorNew":"Two Lines LLC \/ Citruslabs","highestDevelopmentStatusID":"1","companyTruncated":"Two Lines LLC \/ Citruslabs"},{"orgOrder":0,"company":"Contipro Pharma a.s","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Dermatology","country":"CZECH REPUBLIC","productType":"Other Small Molecule","year":"2025","type":"Inapplicable","leadProduct":"Hyaluronic Acid","moa":"Collagen synthesis","graph1":"Dermatology","graph2":"Undisclosed","graph3":"Contipro Pharma a.s","amount2":0,"highestDevelopmentShortName":"Undisclosed","therapeuticAreaShortName":"Dermatology","amount2New":0,"dosageForm":"Gel","sponsorNew":"Contipro Pharma a.s \/ Undisclosed","highestDevelopmentStatusID":"1","companyTruncated":"Contipro Pharma a.s \/ Undisclosed"}]

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                          Top Deals by Deal Size (USD bn)

                          01

                          Lead Product(s) : HA Matrix

                          Therapeutic Area : Dermatology

                          Study Phase : Undisclosed

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Dietary Supplement

                          Upfront Cash : Inapplicable

                          April 14, 2023

                          Lead Product(s) : HA Matrix

                          Therapeutic Area : Dermatology

                          Highest Development Status : Undisclosed

                          Sponsor : Inapplicable

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          Two Lines LLC

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                          ESCRS
                          Not Confirmed

                          Two Lines LLC

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Details : This drug candidate is currently being evaluated in clinical studies for the treatment of Hair Aging.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          August 14, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Dermatology

                          Highest Development Status : Undisclosed

                          Sponsor : Citruslabs

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          Olistic Research Labs S.L.

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                          ESCRS
                          Not Confirmed

                          Olistic Research Labs S.L.

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Details : This drug candidate is currently being evaluated in clinical studies for the treatment of Alopecia.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          August 08, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Dermatology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          Olistic Research Labs S.L.

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                          ESCRS
                          Not Confirmed

                          Olistic Research Labs S.L.

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Details : This drug candidate is currently being evaluated in clinical studies for the treatment of Alopecia.

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          August 08, 2025

                          Lead Product(s) : Undisclosed

                          Therapeutic Area : Dermatology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          ESCRS
                          Not Confirmed
                          ESCRS
                          Not Confirmed

                          Details : Hyaluronic Acid is a Other Small Molecule drug candidate, which is currently being evaluated in clinical studies for the treatment of Skin Diseases.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Inapplicable

                          July 15, 2025

                          Lead Product(s) : Hyaluronic Acid

                          Therapeutic Area : Dermatology

                          Highest Development Status : Undisclosed

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          06

                          Zest Healthtech PLT

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Zest Healthtech PLT

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Details : Eczefolia Extract (Melicope Ptelefolia Extract) is a Plant Extract/Herbal drug candidate, which is currently being evaluated in clinical studies for the treatment of Eczema.

                          Product Name : Eczefolia Extract

                          Product Type : Plant Extract/Herbal

                          Upfront Cash : Inapplicable

                          July 03, 2025

                          Lead Product(s) : Melicope Ptelefolia Extract

                          Therapeutic Area : Dermatology

                          Highest Development Status : Undisclosed

                          Sponsor : UCSI University

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          07

                          Center for Clinical and Cosmetic Research

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Center for Clinical and Cosmetic Research

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Lead Product(s) : Xtressé Supplement

                          Therapeutic Area : Dermatology

                          Study Phase : Undisclosed

                          Sponsor : Restore Biologics Holdings, LLC | Xtressé (TM)

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Xtressé Supplement is a Dietary Supplement drug candidate, which is currently being evaluated in clinical studies for the treatment of Alopecia.

                          Product Name : Undisclosed

                          Product Type : Dietary Supplement

                          Upfront Cash : Inapplicable

                          June 27, 2025

                          Lead Product(s) : Xtressé Supplement

                          Therapeutic Area : Dermatology

                          Highest Development Status : Undisclosed

                          Sponsor : Restore Biologics Holdings, LLC | Xtressé (TM)

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          08

                          ESCRS
                          Not Confirmed
                          ESCRS
                          Not Confirmed

                          Details : The proceeds will be used to advance the ongoing research and development of TFC-1067 for the treatment of dyschromia.

                          Product Name : Undisclosed

                          Product Type : Other Small Molecule

                          Upfront Cash : Undisclosed

                          April 22, 2025

                          Lead Product(s) : Difluorocyclohexyloxyphenol

                          Therapeutic Area : Dermatology

                          Highest Development Status : Undisclosed

                          Sponsor : Promura GmbH

                          Deal Size : $2.1 million

                          Deal Type : Private Placement

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                          09

                          Ablon Skin Institute Research Center

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Ablon Skin Institute Research Center

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Lead Product(s) : Fatty Acid

                          Therapeutic Area : Dermatology

                          Study Phase : Undisclosed

                          Sponsor : U.S. Nutraceuticals, Inc. dba Valensa International

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Undisclosed

                          Upfront Cash : Inapplicable

                          April 10, 2025

                          Lead Product(s) : Fatty Acid

                          Therapeutic Area : Dermatology

                          Highest Development Status : Undisclosed

                          Sponsor : U.S. Nutraceuticals, Inc. dba Valensa International

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          10

                          Simply Plus Co., Ltd.

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Simply Plus Co., Ltd.

                          Country arrow
                          ESCRS
                          Not Confirmed

                          Details : Undisclosed

                          Product Name : Undisclosed

                          Product Type : Protein

                          Upfront Cash : Inapplicable

                          March 28, 2025

                          Lead Product(s) : Collagen

                          Therapeutic Area : Dermatology

                          Highest Development Status : Undisclosed

                          Sponsor : Chia Nan University of Pharmacy and Science

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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