[{"orgOrder":0,"company":"Amphera","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"NETHERLANDS","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"MesoPher","moa":"||Mature dendritic cell","graph1":"Oncology","graph2":"Phase II","graph3":"Amphera","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Amphera \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Amphera \/ Undisclosed"},{"orgOrder":0,"company":"Amphera","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"NETHERLANDS","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"MesoPher","moa":"Mature dendritic cell","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Amphera","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Amphera \/ Undisclosed","highestDevelopmentStatusID":"9","companyTruncated":"Amphera \/ Undisclosed"},{"orgOrder":0,"company":"Amphera","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"NETHERLANDS","productType":"Cell & Gene Therapy","year":"2023","type":"Inapplicable","leadProduct":"MesoPher","moa":"||Mature dendritic cell","graph1":"Oncology","graph2":"Phase II","graph3":"Amphera","amount2":0,"highestDevelopmentShortName":"Ph II","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Amphera \/ Undisclosed","highestDevelopmentStatusID":"8","companyTruncated":"Amphera \/ Undisclosed"},{"orgOrder":0,"company":"Amphera","sponsor":"Undisclosed","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"NETHERLANDS","productType":"Cell & Gene Therapy","year":"2022","type":"Inapplicable","leadProduct":"MesoPher","moa":"Mature dendritic cell","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Amphera","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Injection","sponsorNew":"Amphera \/ Undisclosed","highestDevelopmentStatusID":"9","companyTruncated":"Amphera \/ Undisclosed"},{"orgOrder":0,"company":"Amphera","sponsor":"TMC Pharma","pharmaFlowCategory":"DU","therapeuticArea":"Oncology","country":"NETHERLANDS","productType":"Cell & Gene Therapy","year":"2018","type":"Inapplicable","leadProduct":"Mesopher","moa":"Mature dendritic cell","graph1":"Oncology","graph2":"Phase II\/ Phase III","graph3":"Amphera","amount2":0,"highestDevelopmentShortName":"Ph II\/III","therapeuticAreaShortName":"Oncology","amount2New":0,"dosageForm":"Undisclosed","sponsorNew":"Amphera \/ TMC Pharma","highestDevelopmentStatusID":"9","companyTruncated":"Amphera \/ TMC Pharma"}]

Find Clinical Drug Pipeline Developments & Deals by Amphera

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                          Top Deals by Deal Size (USD bn)

                          01

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : MesoPher (Autologous Tumor Lysate-Loaded Dendritic Cell) is comprised of autologous patient DCs loaded with “PheraLys” – Amphera’s allogeneic lysate of mesothelioma cell lines and being developed for pancreatic cancer.

                          Product Name : MesoPher

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          June 06, 2023

                          Lead Product(s) : MesoPher,Mitazalimab

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase I/ Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          02

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : The DENIM trial confirmed MesoPher’s excellent safety profile and MesoPher induced a robust T-cell response. The immune response did not translate into clinical benefit, and consequently the primary endpoint of an improvement of Overall Survival (OS) w...

                          Product Name : MesoPher

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          December 12, 2022

                          Lead Product(s) : MesoPher

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          03

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : Patients received 3 bi-weekly injections of MesoPher, plus two further injections of MesoPher after 4 and 7 months. Patients in the control arm received best supportive care alone. The primary endpoint of the study is overall survival.

                          Product Name : MesoPher

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          August 01, 2022

                          Lead Product(s) : MesoPher

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          04

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : The latest REACtiVe data for MesoPher showed an average Overall Survival after surgery of approximately 36 months, with 8 of 10 patients alive, which is far beyond expected survival.

                          Product Name : MesoPher

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          May 04, 2022

                          Lead Product(s) : MesoPher,Undisclosed

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II

                          Sponsor : Undisclosed

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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                          05

                          AAPS
                          Not Confirmed
                          AAPS
                          Not Confirmed

                          Details : Mesopher is a Cell and Gene Therapy drug candidate, which is currently being evaluated in phase II/ phase III clinical studies for the treatment of Mesothelioma.

                          Product Name : Undisclosed

                          Product Type : Cell & Gene Therapy

                          Upfront Cash : Inapplicable

                          August 01, 2018

                          Lead Product(s) : Mesopher

                          Therapeutic Area : Oncology

                          Highest Development Status : Phase II/ Phase III

                          Sponsor : TMC Pharma

                          Deal Size : Inapplicable

                          Deal Type : Inapplicable

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